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Biomedical subjects

F Gottrup

Publications and source records attributed to F Gottrup.

123 records · Page 7Linked to original sources
PubMed1980

Effect of beta 2-sympathomimetic on pentagastrin- and histamine-stimulated gastric acid secretion in vagotomized gastric fistula dogs.

The effect of a beta 2-adrenoceptor agonist on pentagastrin- and histamine-stimulated gastric acid secretion was studied in conscious vagotomized gastric fistula dogs. A dose-dependent inhibition was found after pentagastrin stimulation, whereas minor differences were found after histamine stimulation. No major differences between truncal, selective, and parietal cell vagotomy were found after pentagastrin stimulation, whereas one truncal vagotomy dog showed a high inhibition after histamine stimulation. Dose-response experiments with five doses of pentagastrin or histamine (single-dose studies) and two doses of beta 2-agonist suggested a change after vagotomy in the mechanisms of inhibition of gastric acid secretion: for pentagastrin, from a non-competitive type to an uncompetitive type, and for histamine, from a competitive type to a non-significant inhibition. Furthermore, the dose-response curves for the vagotomized dogs were very similar to the curve from intact innervated dogs inhibited by a beta 2-agonist, from an earlier study. These findings may indicate that a decrease in cholinergic tone and an increase in sympathetic tone have identical effects on pentagastrin- and histamine-stimulated gastric acid secretion, and a counterbalance between the two nervous systems on gastric acid secretion is suggested.

Adrenergic beta-Agonists↗
PubMed1980

Prophylactic metronidazole in prevention of infection after appendicectomy: report of a double-blind trial.

A randomized double-blind trial was carried out in 405 patients undergoing appendicectomy to assess the prophylactic effect of metronidazole in postoperative infection. 200 patients received metronidazole and 206 received placebo. Preoperatively all patients were given an intravenous infusion of metronidazole or placebo. In patients with a perforated appendix postoperative medication was continued with suppositories containing either metronidazole or a placebo plus additional chemotherapy with penicillin and streptomycin. The infection rate in patients with a non-perforated appendix was 8% in the placebo group and 1% among those receiving metronidazole. In patients with a perforated appendix, the corresponding figures were 45% and 0%. These differences are statistically significant. B. fragilis and E. coli were isolated from the majority of the postoperative infections;. most often in a mixed culture. Both intravenous and rectal administration of metronidazole gave adequate blood levels. No side effects were encountered.

Adolescent↗
PubMed1979

Effects of beta2-sympathomimetic on histamine-stimulated gastric acid secretion in dogs.

The effect of a selective beta2-adrenoceptor agonist on histamine-stimulated gastric acid secretion was studied in conscious gastric-fistula dogs. A dose-dependent inhibition was found, most pronounced for the lowest doses of histamine. The inhibition was on the volume, whereas the acidity was unchanged. The pulse rate was increased by the beta2-agonist and by histamine. Propranolol prevented the inhibition of acid secretion as well as the increase in pulse rate. Practolol had no effect on the inhibition of acid secretion but reduced the increase in pulse rate. Dose-response experiments with six doses of histamine and two doses of the beta2-agonist showed unchanged calculated maximal response and an increase in D50. It is concluded that the beta2-agonist inhibits histamine-induced acid secretion in the dog, but to a lesser degree that pentagastrin-induced acid secretion, as found in earlier experiments. The inhibition follows competitive kinetics, and beta2-receptors are probably involved. The influence of beta2-sympathomimetics on the mechanism of gastric acid secretion is discussed.

Animals↗
PubMed1979

Effect of two types of beta-adrenergic blockade on gastric acid secretion during pentagastrin stimulation in non-vagotomized and in vagotomized gastric fistula dogs.

The effect of beta-adrenoceptor blockade by propranolol and practolol on submaximally pentagastrin-stimulated gastric acid secretion was studied in conscious non-vagotomized and in vagotomized gastric fistula dogs. Propranolol (0.5 mg/kg) intravenously augmented gastric acid output in vagotomized dogs, more after truncal and selective vagotomy than after parietal cell vagotomy. Vagally innervated dogs also showed an increase, but to a lesser degree and not statistically significant. The increase restored the acid output to preoperative levels in the vagotomized dogs. Practolol (1.0 mg/kg) intravenously resulted in a slight and insignificant increase in acid output in dogs with truncal vagotomy and had only a negligible effect in vagally innervated dogs and after selective and parietal cell vagotomy. It is concluded that propranolol augments pentagastrin-stimulated acid output in vagotomized dogs, and this augmentation was most pronounced in the totally vagotomized stomach. Practolol had minor influence on gastric acid secretion. This effect of the two beta-blocking agents indicates that beta 2-blockade is most important for the secretory augmentation. The restoration of postvagotomy acid secretion to preoperative levels suggests that adrenergic influence is important for the decrease in pentagastrin-stimulated acid secretion after vagotomy.

Adrenergic beta-Antagonists↗
PubMed1978

Inhibition of gastric acid secretion in dogs by a new sympathomimetic drug.

The effect of salmefamol, a new beta 2-agonist, on pentagastrin-induced gastric acid secretion was studied in conscious gastric fistula dogs. Salmefamol inhibited the acid secretion, an effect which was dose dependent. The volume as well as the acidity was inhibited. Salmefamol caused an increase in the pulse rate. Propranolol prevented the inhibition of acid output as well as the increase in pulse rate. Practolol, a beta 1-adrenoceptor blocker, had no effect on the inhibition of acid secretion but prevented the increase in pulse rate. Dose-response experiments with 6 doses of pentagastrin and 1 dose of salmefamol showed a decrease in calculated maximal response (CMR) and an unchanged D50. It is concluded that salmefamol strongly inhibits pentagastrin-induced acid output in the dog, and the inhibition follows a non-competitive kinetic. The mechanism of gastric secretion probably involves a beta 2-receptor.

Animals↗
PubMed1978

Intralobar pulmonary sequestration. A report of 12 cases.

Intralobar pulmonary sequestration signifies an abnormal and non-aerated mass in the lung, supplied by a systemic artery. Twelve cases are submitted, 10 treated by surgery and two conservatively. There was a male preponderance 11:1, and half the patients were over 25 years. In 66% the abnormality was situated basally on the left side A definite diagnosis can be made only by arteriography, visualizing the number, site, and size of the anomalous vessel(s). Clinically, the symptoms may range from no symptoms at all (four of the present patients) to recurrent pneumonia, cough, and haemoptysis (five of the present patients). In two patients the excised tissue showed epithelial proliferations, tumourlets and slight epithelial dysplasia, but no manifest malignancy. Surgical resection is the only curative treatment for intrapulmonary sequestration. In "silent" cases it is felt justified to apply conservative treatment should primary surgery be contra-indicated.

Adolescent↗
PubMedDate not supplied

The wound healing process in surgical patients evaluated by the expanded polytetrafluoroethylene and the polyvinyl alcohol sponge: a comparison with special reference to intrapatient variability.

The aim of this study was to compare two wound healing models in surgical patients with special reference to the intrapatient variability. Two pieces of expanded polytetrafluoroethylene tubing and one perforated silicone tube containing two polyvinyl alcohol sponges were subcutaneously inserted into 28 patients and were removed after 10 (9 to 11) days. The amount of hydroxy-l-proline in two segments of the same piece of expanded polytetrafluoroethylene tubing correlated significantly with each other. Similar results were found for proline. Proline content in each polyvinyl alcohol sponge correlated weakly with each other, whereas no correlation was found between hydroxy-l-proline content in the two polyvinyl alcohol sponges from the same patient. In addition, no correlation was found between leucine in the two adjacent polyvinyl alcohol sponges or between the hydroxy-l-proline/leucine ratio in these same sponges. No concordance could be detected between the averages of hydroxy-l-proline content in the two segments of expanded polytetrafluoroethylene tubing and the hydroxy-l-proline content in the two polyvinyl alcohol sponges from the same person, although an association between the averages of proline in the two pieces of expanded polytetrafluoroethylene tubing and proline content in the two polyvinyl alcohol sponges from the same individual was observed. The measurement error was greater for the polyvinyl alcohol sponges than for the expanded polytetrafluoroethylene tubing implants during the first 10 days after wounding. The expanded polytetrafluoroethylene tubing accumulated 2.5 times more hydroxy-l-proline per length unit than the polyvinyl alcohol sponge. We concluded that the expanded polytetrafluoroethylene implant rather than the polyvinyl alcohol implant is preferred for quantitation of subcutaneous collagen deposition in surgical patients because it accumulates more new tissue and has a lower variability.

Journal Article↗
PubMedDate not supplied

Models for use in wound healing research: a survey focusing on in vitro and in vivo adult soft tissue.

Many different factors must be considered before selecting a wound healing model to use for a specific study. A wide variety of models have been developed that examine different aspects of the repair response, both in vitro and in vivo. In this review article, we focus on those systems that are most widely used for studies on adult soft tissue healing. Advantages and disadvantages of each are discussed, along with relevant background information to help guide decision-making.

Animals↗
PubMedDate not supplied

Increased collagen deposition in an uncomplicated surgical wound compared to a minimal subcutaneous test wound.

Little information is currently available concerning the relationship between results obtained in humans from surgical test wounds and results from wound models. Therefore, to evaluate human wound healing parameters, tubings of expanded polytetrafluoroethylene were implanted in a subcutaneous test wound in the arm of 47 volunteers and 20 patients undergoing hernia repair. The surgical patients also had implants left in the surgical wound cavity. After 10 days the deposition of collagen in the tubings as expressed by hydroxyproline content was 30% higher in the surgical wound than in the test wound, p < 0.05. The amount of collagen deposited in the tubing within the surgical wound did not correlate with measurements in the test wound, whereas a significant correlation of proline levels was found between the two sites, p < 0.05. Deposition of proline and total protein in the model was equivalent. In both wound types age negatively correlated with levels of protein, but not collagen. The variability of the results was 40% lower in the subcutaneous test wound than in the surgical wound. There was no significant difference in hydroxyproline deposition between the volunteers and the patients undergoing hernia repair. In patients undergoing minor surgery without signs of compromised healing the expanded polytetrafluoroethylene test wound in the arm reflects the deposition of non-collagenous protein, but not collagen, within the surgical wound.

Adult↗
PubMedDate not supplied

Sustained silver-releasing dressing in the treatment of diabetic foot ulcers.

This study investigated the clinical performance and safety of a sustained silver-releasing foam dressing, Contreet Foam, in the treatment of diabetic foot ulcers. Twenty-seven patients with diabetic foot ulcers of grade I or II (Wagner's classification) were followed for six weeks: one week run-in using Biatain dressings, four weeks' treatment with Contreet dressings. Four ulcers healed during the four-week treatment with Contreet 56% in average. Contreet Foam showed good exudate management properties and was considered easy to use. Only two infections occurred showed that all six of the non-study ulcers developed an infection during the study. All ulcers (study ulcers as well as non-study ulcers) were treated according to good practice of diabetic wound care. There were no directions for the treatment of secondary wounds. No device-related adverse events were observed. This study demonstrated that Contreet Foam is safe and easy to use and effectively supports healing and good wound progress of diabetic foot ulcers.

Adult↗
PubMedDate not supplied

Bactericidal antimicrobial cover in primary suture of perianal or pilonidal abscess. A prospective, randomized, double-blind clinical trial.

The effect of 1-day treatment vs. 4-day treatment with metronidazole and ampicillin in association with primary closure of perianal and pilonidal abscesses was evaluated in a double-blind clinical trial. The patients were randomly allocated to 1-day (group I) or 4-day (group II) antibiotic regimen. No clinical signs of sepsis appeared in any patient. Primary healing, without fistula formation was achieved in all 17 perianal abscesses in the 1-day therapy group and in 14 of 15 in the 4-day group (non-significant difference). Excision with primary suture of pilonidal abscess resulted in primary healing in 20 of 26 cases in group I and 20 of 30 in group II (non-significant difference). Healing with formation of a new sinus or secondary healing occurred in four and two cases, respectively, in the 1-day therapy group, and in two and nine of the 4-day group. One-day administration of metronidazole/ampicillin is as effective as 4-day treatment in primary closure of perianal and pilonidal abscess. The procedure appears to be safe in both groups, but more efficacious in perianal abscess.

Abscess↗