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Biomedical subjects

F Giordano

Publications and source records attributed to F Giordano.

At least 127 records · Page 7Linked to original sources
PubMed1984

Smear and inclusion cytology in Chiba-needle aspiration biopsy of hepatic tumors.

183 patients underwent fine-needle liver biopsy with a Chiba 22-gauge needle for suspected neoplasia, and the specimens were prepared for smear and inclusion cytology. 149 patients were controlled and 106 were true positives. Of these, 79 yielded material suitable for both methods, which could thus be compared. The results showed that inclusion cytology improves the typing accuracy for the diagnosis of well-differentiated primary liver tumors. Further, specimens for embedding can be obtained with ordinary Chiba 22-gauge needles which are normally used only for obtaining material for smear cytology.

Adenocarcinoma↗
PubMed1984

Multinucleated giant cells in myeloma kidney: an ultrastructural study.

The origin of multinucleated giant cells in myeloma kidney is not yet defined. These cells have long been thought to represent tubular epithelial cells transformed in syncytia, but, more recently, they have been considered as histiocytic cells arising from the interstitial tissue. We have studied by electron microscopy the distal tubules of kidney biopsies of 5 patients affected with myeloma kidney: our ultrastructural findings do not seem to clarify the problem. In fact, in the same patient, we have observed multinucleated giant cells probably originating from epithelial tubular cells and others, probably originating from histiocytes.

Cell Nucleus↗
PubMed1981

[Transport of cytidinediphosphocholine in different biological models. I - Synthesis and characterization of (5 3H, Met 14 C) cytidinediphosphocholine].

In order to investigate the transport of CDP-choline across the biological membranes we have synthesized the double labeled CDP-choline. The (5 3H, methyl 14C) CDP-choline is synthesized by a crossed condensation of (5 3H) CMP and methyl 14C) p-choline using DCC as condensing agent. The product of the reaction is identified by chromatographics and spectroscopics methods.

Carbon Radioisotopes↗
PubMed1981

[Possible regulatory role of 5'-methylthioadenosine on enzymatic methyl esterification of membrane protein].

In the present study the effect of 5'methylthioadenosine (MTA), a natural metabolite of S-adenosylmethionine (AdoMet), on the enzymatic methyl esterification of intact erythrocyte membrane proteins has been investigated. The thioether significantly affects the methylation process :50% inhibition being observable at 100 microM MTA. This inhibition is due to the action of MTA on the enzyme protein methylase II. Since MTA is present in micromolar amounts in the cells, the reported effect could be of physiological interest and suggests a new regulatory role of this AdoMet metabolite.

Adenine↗