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Biomedical subjects

F Geubelle

Publications and source records attributed to F Geubelle.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Short term efficacy of inhaler beta2 agonists in childhood asthma (author's transl)].

An attempt was made to assess the relationship between the bronchodilator response of three beta2-agonists (fenoterol salbutamol and terbutaline) administered by a metered aerosol inhaler during 43 lung function measurements on 25 asthmatic children. At constant one minute intervals the changes in total pulmonary flow resistance (R1) and dynamic lung compliance (C1 dyn) were measured. The effect of the three bronchodilators on the mean decrease of R1 was similar and not significantly different. Since R1 may fail to detect peripheral airway obstruction, the efficiency of the three drugs was evaluated on the basis of changes on C1 dyn in two subpopulations, one without signs of overinflation and one with evident overinflation, as judged from the initial values of the functional residual capacities and the C1 dyn's. On the basis of this distinction it is suggested that fenoterol has its predominant effect on patients with overinflation of the lungs and increased C1 dyn probably due to a loss of elastic recoil. Salbutamol is more efficient in patients suffering from a "primary bronchial disease", Terbutaline is equally effective in both.

Adolescent↗
PubMed1982

[Serum gamma-glutamyltransferase activity in a pediatric population].

Serum gamma-glutamyltransferase activity was measured in healthy children from birth (cord blood) up until the age of 15 years. Reference values were established. The résults show that GGT activity in cord blood is inversely proportional to birth weight. It can be up to ten times the normal adult value. These raised values would be explained by the hypothesis of a foetal GGT which disappears during the first week of life. During the first ten days of life, the range of values is so wide that a single estimation of GGT activity cannot be a particular useful diagnostic. The lowest values for GGT activity are found between the ages of two and three: they are lower than in the adult. No difference was detected between the activities measured in boys and girls.

Adolescent↗
PubMed1982

[Bronchogenic cysts. A clinical and regional lung function study before and after surgery (author's transl)].

Studies of regional lung function were performed on two children with bronchogenic cysts before and after surgery. The first patients, aged two, presented with a severe and continuous airflow obstruction leading to significant disturbance of perfusion per unit of alveolar volume; the abnormalities of perfusion were partly reversible when the ventilation was restored after surgery. Patient no 2, aged 10 years, had a voluminous peripheral cyst, which was shown to be ventilated by pulmonary function studies and further confirmed by bronchography. After lobectomy, studies revealed a reduction in the functional pulmonary parenchyma in the right hemithorax. The abnormal distribution of perfusion was still seen two years after the operation.

Adult↗
PubMed1981

Mode of action of bronchodilating drugs on histamine-induced bronchoconstriction in asthmatic children.

The bronchodilatory response of three beta 2-agonists (fenoterol, salbutamol, and terbutaline), administered by a metered aerosol inhaler, was assessed in 19 asthmatic children after histamine-induced bronchoconstriction. At 1-min intervals, the changes in total pulmonary flow resistance (R1) and dynamic lung compliance (C dyn) were measured. After rank-ordering according to the base line value of C dyn (62 to 200% predicted), the patients were divided into two groups according to lung compliance: (1) patients with greater compliance (C dyn, 129 to 200% predicted) and (2) patients with lesser compliance (C dyn, 69 to 116% predicted). The effect of the three bronchodilators on the mean decrease of R1 and on the increase of C dyn was studied and analyzed for each drug separately. In all patients, salbutamol was the most efficient bronchodilator of small airways (P less than 0.02). The most striking feature of this beta 2-mimetic was observed in patients whose lungs were initially overinflated (functional residual capacity over 120% predicted) but not obstructed before the histamine challenge (P less than 0.005). In these subjects C dyn and R1 are normalized after inhalation of salbutamol. After fenoterol and terbutaline inhalation, obstruction of the large airways was not fully alleviated. In addition, these two drugs seemed not to affect the ventilatory asynchronism (C dyn alterations) in patients whose lungs had been overinflated before drug inhalation (C dyn again around 150% predicted).

Adolescent↗