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Biomedical subjects

F Geubelle

Publications and source records attributed to F Geubelle.

At least 19 recordsLinked to original sources
PubMed1989

3C syndrome: third occurrence of cranio-cerebello-cardiac dysplasia (Ritscher-Schinzel syndrome).

We report a child with an unusual pattern of malformations: severe delay in bone maturation, wide fontanelles and facial dysmorphism (evoking cleidocranial dysplasia), relative macroencephaly with cerebellar vermis hypoplasia, hypertelorism, skeletal abnormalities (1st ribs aplasia, multifocal sternal ossification centers, thin bones), septal defect, muscular waste, hypotonia and developmental delay. Most of these features have been reported previously by Ritscher, Schinzel et al. in two sibs, who suffered more severe cerebellar malformations (Dandy-Walker cyst or vermis aplasia). We propose 3C syndrome as an easy acronym for this Cranio-Cerebello-Cardiac dysplasia.

Abnormalities, Multiple↗
PubMed1989

[Arterial pressure in adolescents: epidemiologic approach].

The epidemiological survey of a sample of Belgium teenagers aged from 12 to 17 provides the reference values of blood pressure and illustrates the importance of weight and mainly of overweight as a determinant of blood pressure in this population. The longitudinal part of the study clearly establishes the importance of the tracking phenomenon and the significance of the casual finding of an elevated blood pressure in a teenager aged from 13 to 17 years.

Adolescent↗
PubMed1988

Alveolar data in healthy, awake neonates during spontaneous ventilation: a preliminary investigation.

A computerized method for the measurement of alveolar ventilation (VA) and the mean alveolar partial pressures of CO2 and O2 is described and tested in healthy, awake fullterm (FT) newborns and preterm (PT) infants (postnatal age 40 days). This study emphasizes the technical pitfalls generally encountered when dealing with very small infants. A sensitive pneumotachograph with a small dead space volume and a low-flow sampling system for the gas analyzer are minimum requirements. Under these technical conditions, the major problem is the scanning time of the mass spectrometer (50 Hz), which fixes the time constant, as well as the digitization sampling rate of the gas signals. This rate was not sufficient when the respiratory rate was above 90 min-1. As critical visual evaluation of each breath is required, fully automatic access to mean alveolar data is not possible. The mean dead-space volume in both FT and PT infants was 2 ml.kg-1, with a VD/VT ratio of 0.3. The mean alveolar point was 2/3 VT, as found in adults. When expressed as ml.min-1.kg-1, VA appeared to be higher than in other studies, but related to the metabolic requirements. (VCO2 = 7.8 +/- 0.2 ml.min-1.kg-1 and VO2 = 8.0 +/- 0.2 ml.min-1.kg-1), in accordance with the state of vigilance of the neonates. Indeed, the PACO2 values, which depend on the ratio VCO2/VA, are in agreement with the values of PaCO2 generally considered normal in healthy newborns over 1 week of age.(ABSTRACT TRUNCATED AT 250 WORDS)

Humans↗
PubMed1988

Respiratory compliance of healthy newborn infants measured by endinspiratory airway occlusion technique in the first hours of life.

The compliance of the respiratory system (Crs) has been measured by an airway occlusion technique in 78 healthy newborn infants [gestational age (GA) 36.2 +/- 2.9 weeks, range 28-41 weeks; birth weight (BW) 2.418 +/- 0.879 kg, range 0.830-4.350 kg; body height (BH) 45.2 +/- 4.4 cm, range 33-52 cm in the first 8 h after birth (206.2 +/- 100.8 min, range 45-480 min). The prediction equations were (Crs, ml/cm H2O): Crs = 0.087.GA -1.173 (r = 0.49, p less than 0.0001), Crs = 0.372.BW +1.067 (r = 0.62, p less than 0.0001), Crs = 0.076.BH -1.493 (r = 0.61, p less than 0.0001). The Crs values were very similar to the values measured in curarized newborn infants and quoted in the literature. There was only one newborn infant with a Crs of less than 1 ml/cm H2O (GA = 34 weeks, BW = 0.830 kg, BH = 33 cm, Crs = 0.909 ml/cm H2O).

Birth Weight↗