The different effects of sodium regimens administered over a period of five days were studied in 18 normal men, aged 21 to 27 years. As the dietary sodium increased, there was a parallel increase in osmolality, plasma volume, reabsorption of free water, and secretion of antidiuretic hormone. However, there was a decrease in plasma renin activity, plasma aldosterone and urine aldosterone. All of these parameters correlated significantly with the urinary sodium. Plasma prolactin did not appear to be influenced by low, normal or high sodium regimens; its values being 3.1 +/- 1.1, 2.9 +/- 1.7, 2.7 +/- 1.2 ng/ml respectively at 9 AM in an upright position. Once more, there does not exist any correlation between the plasma prolactin levels and the parameters mentioned above. In conclusion, variations in dietary sodium do not influence plasma prolactin levels in the normal human being.

Adult↗

PubMedDate not supplied

[Effects of low, normal and high sodium diet on antidiuretic hormone and prolactin (author's transl)].

Urinary antidiuretic hormone is very significantly correlated with sodium urinary output (r = 0,78; n = 54; p 0,001) observed during different sodium diet on eighteen healthy male subjects. Whereas antidiuretic hormone increase with sodium intake and renin-angiotensin-aldosterone system is suppressed, no prolactin variation is observed. Supine or upright position does not modify prolactin which decrease between 9 and 10 a.m. These results do not support a role for prolactin in sodium and water regulation, and show that sodium output has to be measured with urinary antidiuretic hormone.

Diet, Sodium-Restricted↗