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Biomedical subjects

F Gaillard

Publications and source records attributed to F Gaillard.

At least 55 records · Page 3Linked to original sources
PubMed1995

[Breast cancer and hMG treatment: is there a relationship?].

The promoter effect of oestradiol in breast cancer, the higher risk of breast cancer in infertile nulliparous women and the increased use of treatments to include ovulation would suggest that the risk of cancer after this type of treatment might be affected. We thus evaluated the files of patients under 45 years of age treated for breast cancer at the Bergonié Foundation. Six such cases were found. Due to the small number of cases observed to date, no statistical analysis could be performed. Nevertheless, several cases may have gone unrecognized or unpublished. Two hypothesis might be involved: the facilitating effect of stimulation on infraclinical or undiagnosed cancers, initiation of new cancers. We thus propose: a register to follow treated women in order to monitor the appearance of new cases of cancer, improved surveillance in patients with other associated risk factors.

Adult↗
PubMed1995

[Abdominal lymphomas in children: place of surgery].

To determine the place of surgery in the management of abdominal Burkitt's lymphoma, we retrospectively reviewed the records of 17 children treated over a period of 10 years (1983-1992). Patients were 14 males. Seven patients presented with acute abdominal pain, 6 with an abdominal mass and 5 with intestinal obstruction. In 3 cases, the diagnosis was made without laparotomy (2 percutaneous tumoral puncture, 1 pleural puncture). In the 14 other cases, the diagnosis was made by laparotomy with 3 biopsies and 11 resection of the tumor (7 complete and 4 incomplete). These laparotomies were complicated by 1 evisceration and 2 intestinal obstruction. At the end of the initial chemotherapy, 1 children was reoperated for a residual mass with no histological viable tumor. Sixteen children were long term survivors (14 > 2 years); 1 died. Surgery was indicated in cases of intestinal intussusception. In cases of abdominal mass, surgery could have been avoided twice (positive ascitic fluid). A complete tumoral resection had no influence on survival which depend of extra-abdominal extension and more over of response to chemotherapy.

Abdominal Neoplasms↗
PubMed1994

Testicular tumor and the acquired immunodeficiency syndrome.

Immunocompromised patients, particularly those suffering from the acquired immunodeficiency syndrome (AIDS), present an increased risk of tumoral pathology. From the observation of a testicular lymphoma associated with Epstein-Barr virus in a HIV + patient, we review 19 cases of testicular tumor in HIV + patients previously published in the literature. These tumors are either lymphomas (4 cases) or germ cell tumors (15 cases). Their diagnosis was not difficult, although in the first stages enlarged and painful testicles are often wrongly identified as orchiepididymitis and treated as such. Therapy management proves to be delicate as a result of the significant tumor spread seen in these patients with dysfunctional immune systems. Regarding lymphomas, a low-dose multiagent chemotherapy with intrathecal chemotherapy was recommended by Levine. Concerning germ cell tumors, Wilson prefers an instant aggressive treatment with retroperitoneal lymphadenectomy (whether or not combined with chemotherapy) to avoid the risk of recurrence. In fact, tumor relapses will be difficult to control in the progressive stages of immunodeficiency syndrome.

Adult↗
PubMed1993

[The role of adrenal gland x-ray computed tomography and scintigraphy using radiolabelled norcholesterol in the etiological diagnosis of primary hyperaldosteronism].

The major etiologies of primary aldosteronism are aldosterone-producing adrenal adenoma, requiring a surgical treatment, and bilateral hyperplasia, usually managed with medical therapy. We only report a retrospective study on 22 patients with primary aldosteronism diagnosed by clinical and usual biochemical tests. All the patients were explored by computed tomography scan (CT) and iodomethyl-norcholesterol scintigraphy. The purpose of this study was to compare the capacity of the two methods to differentiate adrenal adenoma and hyperplasia. The CT scan was more sensitive (sensitivity: 88%) compare to scintigraphy (sensitivity: 64%) for the diagnosis of adrenal adenoma. However, the scintigraphy was a useful tool to detect asymmetric macronodular adrenal hyperplasia. Therefore, the catheterisation of adrenal venous would be only necessary for a few cases. We conclude from this study and the literature review that CT scan and iodomethyl-norcholesterol scintigraphy are complementary and both useful to increase diagnostic reliability of primary aldosteronism.

19-Iodocholesterol↗
PubMed1993

[Extramedullary hematopoiesis. An unusual cause of Pagetic spinal cord compression].

An original case is reported: spinal cord compression due to extramedullary hematopoiesis of the epidural space, related to Paget's disease of bone, successfully treated by surgery. Extramedullary hematopoiesis, usually occurring in cases of hematological disease, can also complicate Paget's disease, probably by bone effraction mechanism. A review of literature has found 5 other cases of extramedullary hematopoiesis occurring in Paget's disease, without hematological disease. Medullar scintigraphy (Indium111, Technetium99 Sulfur colloid) can confirm the diagnosis after X-ray findings, without the need for biopsy. Awareness knowledge of this complication can sometimes avoid invasive investigation. Low dose radiotherapy is useful in the case of hematological disorders. In Paget's disease, there is a risk of sarcomatous degeneration. In our patient, surgery cured cord compression, but it relapsed because of extensive fibrosis, in complicating surgical hemorrhage.

Aged↗
PubMed1992

Primary Epstein-Barr virus infection with clonal T-cell lymphoproliferation.

A case of fatal Epstein-Barr virus infection in a previously healthy girl who was first found to have severe infectious mononucleosis with spontaneous recovery is reported. Because an abnormal immune response to the virus persisted, the disease relapsed, manifesting in cutaneous and pulmonary lesions associated with hemophagocytic syndrome responsible for death. Pathologic findings were characterized by polymorphous atypical lymphoid infiltrate, prominent necrosis, and histiocytic hyperplasia. Lymphoid cells displayed CD8 phenotype and clonal T-cell receptor gene rearrangement. Viral genome was detected in lesions by Southern blot and located in nuclei of lymphoid cells by in situ hybridization. Pathologic findings suggested fatal infectious mononucleosis; however, phenotype and genotype favored a malignant diagnosis. Clonality was demonstrated to have arisen during primary infection. Virologic examination indicated that Epstein-Barr virus was a causative agent. Such a process belongs to the recently recognized spectrum of Epstein-Barr virus-related T-cell lymphoproliferative disorders that might overlap fatal infectious mononucleosis in patients who are especially vulnerable to the virus.

Adolescent↗
PubMed1992

Immunohistochemical detection of cells positive for colony-stimulating factor 1 in lymph nodes from reactive lymphadenitis, and Hodgkin's disease.

Colony-stimulating factor 1 (CSF-1) is a cytokine involved in hematopoiesis and perhaps more importantly in the early stages of immunological defense mechanisms. Although numerous studies of in vitro CSF-1-producing cells have been published, in vivo data is totally lacking. According, we performed immunohistochemical detection of CSF-1-positive cells on frozen sections of reactive lymphadenitis (three cases) and Hodgkin's disease (13 cases) lymph node biopsies, using as antibody a highly specific polyclonal rabbit antiserum prepared in our laboratory. Endothelial cells from high endothelial venules and most fibroblasts were positive in all cases (reactive lymphadenitis and Hodgkin's samples), and most lymphocytes in interfollicular T cell areas showed faint granular positivity in reactive lymphadenitis lymph nodes. Hodgkin and Reed-Sternberg cells were positive in all cases tested, although staining intensity was highly variable and the percentage of positive cells differed from case to case. These data from in vivo biopsies confirm previous results for in vitro CSF-1 production by endothelial cells, fibroblasts, T lymphocytes, and Hodgkin cell lines. They are consistent with the role of this cytokine in immune response and raise the question of its significance in Hodgkin's disease.

Hodgkin Disease↗
PubMed1991

[Vertebral compressions revealing Cushing's syndrome. 3 cases].

The authors report three cases of osteoporotic vertebral fractures in the Cushing Syndrome. This osteoporosis is partially reversible after treatment of the cause. Laboratory findings must comport a cortisonuric and a 17 hydroxycorticosterone cycle.

Adult↗
PubMed1990

[Prognostic and therapeutic aspects of lympho-epithelial lesions of the parotid. Apropos of 8 cases].

The so-called benign lympho-epithelial lesion (BLEL) of the parotid is a rare condition. Its diagnosis is based on histology. For a long time there have been problems with its classification and prognosis: classification since certain cases may be classified as Sjögren's syndrome or as a precursor of the latter, prognosis there may be recurrence, contralateral involvement or progression to non-hodgkin's lymphoma. The authors discuss these factors in 8 cases and propose total parotidectomy with facial nerve preservation as the treatment of choice.

Adult↗
PubMed1989

Quantitative studies on ipsilateral type 2 retinotectotectal (IRTT) units in frogs: homologies with R3 ganglion cells.

Contralateral and ipsilateral responses from deep layers of the rostral neuropil of the optic tectum of Rana esculenta were recorded extracellularly and quantitatively analyzed. Effects of the velocity and diameter of the stimulus on the neuronal response (measured as the mean firing frequency, R) were mainly tested in this work. 1. Among the population of changing contrast or event ganglion cells, R3-like units (with a weak response to background off-on stimulation) were defined in addition to typical R3 ganglion cells. 2. A power function relating R and the stimulus velocity (v) was established in all units (R = k v alpha), with alpha = 0.80-1.07 and k = 2.1-9.5 for R3 units, alpha = 0.55-0.77 and k = 5.8-15.2 for R3-like units, and alpha = 0.80-1.16 and k = 1.3-5.1 for ipsilateral I2 units. 3. The area function was expressed by a logarithmic function. In all classes the maximal response was obtained with 4.4 degrees-7.5 degrees targets, independent of the test velocity. 4. Both the velocity and the diameter of the stimulus influenced the value of the dynamic receptive field diameter. 5. Finally, results show that qualitative and quantitative properties of I2 units are similar to those of R3 ganglion cells.

Action Potentials↗
PubMed1989

Quantitative stimulus-response studies on sustained ganglion cells in the frog retina.

"Sustained" visual units, i.e. nonerasable (R1) and erasable (R2) units as commonly described, were recorded in the superficial layers of the rostral optic tectum of Rana esculenta and their neuronal activity (expressed as the mean firing frequency R) was quantitatively analyzed. The mean value of the exponent alpha of the velocity function of the erasable R1 units was found to be 0.46 and the constant k to be about 24.7. The optimal stimulus diameter was equal to 2.6 deg. For the whole population of the erasable units, the exponent alpha was found to be between 0.36-0.75 (mean value approximately 0.56, i.e. largely different from the values currently reported for such units) and was independent of the stimulus diameter (D = 0.6-6 deg). However, the constant k of the velocity function (range: 8.2-37.7) varied with D. Most of the erasable units (called "mixed R1-R2" units) therefore showed an R1-type velocity function with an exponent alpha approximately 0.5 and a constant k approximately 25 but reacted to other parameters as did "typical" R2 units: (i) their neuronal response was related to the stimulus diameter by a logarithmic function with a maximum obtained for D = 2.4 deg; and (ii) a variation of about 4-17% on either side of the average value of R was observed, independent either of the stimulus velocity or of the diameter of the stimulus. Results are compared to known quantitative data, and the use of stimulus-response relationships as a tool for classification is discussed.

Animals↗
PubMed1988

Cost and quality of psycho-pedagogic institutional care: the case of 56 establishments in the Swiss canton of Vaud.

We studied 56 boarding institutions caring for 834 children and adolescents with different kinds of difficulties or handicaps in the Swiss Canton of Vaud. In order to weigh the purely qualitative approach we performed two different statistical analyses: 1) a correlation matrix between all qualitative and quantitative variables with the daily individual cost of the institutional care. This cost has been calculated in a standard manner and independently of each institution's accounts. 2) a factor analysis of the collected data led us to the identification of different patterns of institutional functioning. This study stresses the importance of the staff/pupil coefficient, i.e. the richness of the pedago-therapeutic framing--the intervention of specialists such as special teachers, psychologists, and speech and/or motor therapists-, and more particularly the higher ratio of specialist help compared to pure educative staff. The severity of the cases, evaluated by independent specialist observers, was in direct relation to this factor independently of the kind of difficulty or handicap.

Adolescent↗
PubMed1988

[Carney's complex (myxomas, pigmented spots and endocrine hyperactivity). Apropos of a partial form in monozygotic twins].

The authors describe monozygotic twins with right ventricular myxoma, one of whom had cutaneous myxomas, large cell calcifying Sertoli cell tumor of the testis (a lesion which was certainly latent in his brother) and recurrent cardiac myxoma. These elements are manifestations of "Carney's complex". This recently reported inherited syndrome should be recognized by pathologists because of major risk of cardiac myxoma. Cutaneous lesions, specially cutaneous myxomas, are heralds of this syndrome.

Adolescent↗