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Biomedical subjects

F Furlanello

Publications and source records attributed to F Furlanello.

At least 91 records · Page 5Linked to original sources
PubMed1981

[The phenomenon of accelerated A-V conduction. Electrophysiological study with a "selective" calcium antagonist (Verapamil)].

In order to discover slow response calcium dependent fibers within the structure with enhanced A-V conduction, an acute i.v. test with Verapamil (a highly selective calcium antagonist) was done in 13 patients with enhanced A-V conduction syndrome (4 had A-V by-pass, Kent type, associated). The action of Verapamil on the following parameters was studied: 1) A-H interval in sinus rhythms; 2) delta A-H interval (i.e. the maximum increment of A-H interval after incremental atrial pacing); 3) antegrade and retrograde function curves of the structure with enhanced A-V conduction; 4) R-R cycle of the reciprocating tachycardia, antegrade and retrograde conduction time (after identification of the reentry circuit) and pattern of induction and interruption of the tachycardia. Only in 1 patient a total atrio-hisian by-pass was identified. In all the other patients the electrophysiologic response to i.v. Verapamil suggested the presence of slow response calcium dependent fibers within the structure with enhanced A-V conduction which was always depressed by the drug even if to a lesser degree than in a normal A-V node. From these data and from the analysis of the epidemiology of enhanced A-V conduction, the Authors hypothesize that an infantile type A-V node could be in most cases the anatomical basis of enhanced A-V conduction while only rarely a total or partial A-V node by-pass.

Adolescent↗
PubMed1981

[Another type of interaction between blood levels of digitalis and anti-arrhythmic drugs: digoxin and amiodarone. Experience with long-term therapy].

In clinical Arrhythmology it is often necessary to associate digitalis and antiarrhythmic agents. This calls for study of possible interaction between the employed drugs. We found a statistically significant correlation between digitalis and amiodarone plasma level in patients on long term treatment with both drugs. A statistically significant linear correlation between plasma amiodarone level and digoxin (0.25 mg/day) or beta-methyldigoxin (0.20 mg/day) was documented in 33 patients. 23 patients had been treated with these drugs for paraxysmal reciprocating supraventricular tachycardia since an average of 52 months (computerized follow-up). (Amiodarone average weekly dose was 1078 +/- 168 mg after a loading dose of 12 gm given over one month). 10 patients were on chronic treatment with higher weekly doses of amiodarone (average dose 2380 +/- 731 mg per week). Thyroid function tests (T4; T3; T3UP; TSH; rT3) were checked in every patients. Further studies are warranted to understand the mechanism of the interaction between amiodarone and digitalis. As a clinical implication we point out that amiodarone-digoxin (or betamethyldigoxin) interaction in our patients has neither resulted in over-therapeutic plasma level nor in signs of digitalis toxicity.

Aged↗
PubMed1980

[The use of pace-makers with programmable frequency in the control of hyperkinetic ventricular "refractory" arrhythmia (author's transl)].

The electrophysiological basis of the treatment of hyperkinetic "refractory" arrhythmias with rate - programmable pacemakers, stems from the pacing-inducted electrophysiological modifications with higher and time programmable threshold rates being obtainable to suppress the arrhythmias. Furthermore antiarrhythmic agents, that must be generally associated, are more safely employed. This is a new application in clinical arrhythmology of a particular type of permanent pacemaker whose classic indications are well known. The Authors report their experience relative to 16 selected patients affected by severe cardiopathies. Three types of pacemakers were employed: Omnis Stanicor Cordis; Microlith C.P.I.; and Byrel A-V Sequential, Medtronic. The results, in term of the suppression of the arrhythmias, were encouraging. The most striking problem is to match the "rate threshold" for the suppression of the arrhythmia with the patient's hemodynamic tolerance: not infrequently in fact the programmed rates are poorly tolerated by the patient either because of heart failure or due to coronary insufficiency. These patients need frequent adjustment of the stimulation rate. The availability of rate programmable pacemakers with steps of one beat per minute, of A-V sequential stimulation and, when feasible of atrial stimulation, undoubtedly plays an important role in clinical arrhythmology.

Arrhythmias, Cardiac↗