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Biomedical subjects

F E Bloom

Publications and source records attributed to F E Bloom.

At least 451 records · Page 25Linked to original sources
PubMed1969

Lesions of central norepinephrine terminals with 6-OH-dopamine: biochemistry and fine structure.

Intracisternal injections of 6-hydroxydopamine produce rapid and long-lasting depletion of brain catecholamines without effects on serotonin concentrations. Depletion of norepinephrine is greatest in areas containing only nerve terminals and axons and least in areas containing monoamine cell bodies. The norepinephrine loss is accompanied by electron microscopic evidence of nerve terminal degeneration and decreased turnover. Dopamine loss is less marked and is not accompanied by degeneration or alteration of turnover rate.

Animals↗
PubMed1969

Cyclic adenosine monophosphate: possible mediator for norepinephrine effects on cerebellar Purkinje cells.

Microelectrophoretic application of norepinephrine or cyclic adenosine monophosphate reduces the discharge frequency of Purkinje cells in the rat cerebellum. In contrast, other nucleotides accelerate the discharge rate of most units. Parenterally administered theophylline, which inhibits the hydrolysis of cyclic adenosine monophosphate enhances the effects of norepinephrine and cyclic adenosine monophosphate. Therefore, norepinephrine may be able to regulate Purkinje cells functionally by metabolic stimulation of cyclic adenosine monophosphate synthesis.

Action Potentials↗
PubMed1966

Cytochemistry of synapses: selective staining for electron microscopy.

Material at synapses and in some synaptic vesicles becomes selectively stained when glutaraldehyde-fixed rat brain that has not been treated with osmium is stained with phosphotungstic acid. The material stained at synapses is distinct from the adjacent unstained synaptic membranes and has cytochemical properties of protein. The specialized spatial arrangement exhibited by this synaptic material suggests its close involvement in synaptic function.

Aldehydes↗