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Biomedical subjects

F Daschner

Publications and source records attributed to F Daschner.

At least 271 records · Page 15Linked to original sources
PubMed1976

[Significance of diagnostic parameters in recurrent urinary tract infection in children. I. The history (author's transl)].

Comparison of the history of 136 children with recurrent urinary tract infection (UTI) with their follow up in a special urologic service (260,6 patient years) showed marked differences in symptoms of recurrent UTI prior to follow up (769 "anamnestic" recurrent UTI) as compared to true significant bacteriuria (278 recurrent UTI during follow up). Therefore parents statements about time of first UTI and incidence of further recurrences should be considered with caution. Only 10% of the physicians proved their diagnosis "UTI" bacteriologically. Anamnestic data, however, are of great importance for the follow up of children with recurrent UTI: children with many recurrences in their history have a greater risk of further recurrences despite careful follow up, and tend to have more pathologic findings on first radiologic examinations.

Age Factors↗
PubMed1976

[Different antibody tests (IgG, IgM) from children with chronical recurrent urinary tract infections (author's tranls)].

Different Antibody tests (IgG, IgM) were made from children with chronical and recurrent urinary tract infections with help of the indirect fluorescent method and were compared with the indirect hemagglutination test. The indirect hemagglutination gave absolutely higher antibody rest results, but the specifity of the immune fluorescence test is just as large. You can see the acute attacks of pyelonephritis in either the antibody response test or IHA test. It is quite important, in the beginning, to repeat the controlls of the antibody test, because the changes that could occure in the titer should be seen. The IgG antibody reactions rise slightly during the acute attacks of E. coli- and Enterococci reinfections.

Adolescent↗
PubMed1976

[In vitro effect of cephacetril and colistin combinations on Klebsiella pneumoniae and Proteus Strains (author's transl)].

In 14 out of 43 Klebsiella pneumoniae strains (33%) the combination cephacetril-colistin showed a synergistic, in 11 strains (25%) an additive effect. In Proteus strains no synergistic action was found. The combination was more likely to be synergistic or additive in strains requiring higher minimal inhibitory concentrations of cephacetril and colistin. Most highly resistant Klebsiella pneumoniae strains were synergistically inhibited by concentrations of both drugs, which can easily be obtained in serum by usual clinical doses.

Cephacetrile↗
PubMed1975

[Contaminated infusions as cause of nosocomial Serratia marcescens septicaemia in children (author's transl)].

At the University Children's Clinic at Munich 25 cases of Serratia marescens septicaemia (mainly bacteriocin types 18 and 44) occurred within one year, predominantly in newborns and infants. Almost all of the children were seriously ill from an underlying illness or had been operated on. Two thirds had received antibiotics before the septicaemia occurred but they were ineffective. Of a total of nine antibiotics tested against 51 Serratia marcescens strains, nalidixic acid (99% sensitivity) and amikacin (100%) proved the most effective. Main source of the septicaemia were contaminated infusions, from which in as many as 35% of cases microorganisms, usually Serratia marcescens, had been isolated. Intensive hygienic measures at once terminated this "sepsis wave".

Age Factors↗
PubMed1975

[Phagocytosis of cell wall defective bacteria by human macrophages (author's transl)].

Statistically significant better phagocytosis of spheroplasts was found by comparing the rate of phagocytosis of normal and Penicillin-G induced cell wall defective bacterial (spheroplasts) by human macrophages in isotonic media using a Proteus mirabilis strain as test organism. This provides additional information concerning the minor role of cell wall defective bacteria as persisters in chronic infections.

Bacterial Infections↗
PubMed1975

Treatment of recurrent urinary tract infection in children. II. Compliance of parents and children with antibiotic therapy regimen.

Since none of the studies of long-term management of recurrent urinary tract infections considered the possibility of patients' not taking medication, compliance with long-term antibiotic therapy was tested by urine check in 93 children with recurrent urinary tract infection. Only 30 children (32.2%) took the prescribed drugs at regular intervals, 27 children (19.1%) did not take the antibiotics at all and 36 patients took the drugs irregularly, skipping one or two doses a day. The difference in infection rate between regular takers (3.9/year) and non-takers (7.2/year) and irregular takers (4.8/year) and non-takers was statistically highly significant. Forgetfulness and negligence of the parents was found to be the main reason for not giving the child the medication. Treatment studies which show the advantage of one regimen over another or which try to define optimal duration of therapy should take particular care in evaluation compliance.

Administration, Oral↗