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Biomedical subjects

F Darnis

Publications and source records attributed to F Darnis.

At least 91 records · Page 5Linked to original sources
PubMed1976

[The liver and metabolism of drugs].

Even if all problems of liver metabolism have not yet been clarified, it is nevertheless established that medicaments induce enzymes in the hepatic cells which influence the metabolism of drugs. Because their effect is unspecific, these enzymes can catabolize many drugs with different structures. About 200 substances are known which induce such enzymes. Among them, for example, is phenobarbital. It is therefore used in the treatment of some forms of icterus with free bilirubin and for Cushing's syndrome. But enzyme induction can also lead to acute intermittent porphyrias and disturbances of the phosphorus-calcium metabolism. Extreme catabolism of a drug can be caused by overinduction of enzymes due to the administration of several incompatible medicaments.

Biotransformation↗
PubMed1976

[Liver metabolism of drugs (author's transl)].

Even if all problems of liver metabolism have not yet been clarified, it is nevertheless established that medicaments induces enzymes in the hepatic cells which influence the metabolism of drugs. Because their effect is unspecific, these enzymes can catabolize many drugs with different structures. About 200 substances are known which induce such enzymes. Among them, for example, is phenobarbital. It is therefore used in the treatment of some forms of icterus with freee bilirubin and for Cushing's syndrome. But enzyme induction can also lead to acute intermittent porphyrias and distrubances of the phosphorus-calcium metabolism. Extreme catabolism of a drug can be caused by overinduction of enzymes due to the administration of several incompatible medicaments.

Adult↗
PubMed1975

[Encephalopathy in acute hepatic atrophy. Effect of the purification of middle molecules. Preliminary results].

The authors have achieved 5 complete recoveries from coma and two partial recoveries in 9 non-decerebrate patients in coma due to acute hepatic atrophy by using polyacrylonitrile membrane haemodialysis. Survival was not possible until sufficient hepatic regeneration had developed. On the other hand, repeated returns to consciousness were observed with prolonged survival lasting up to 40 days despite almost complete destruction of the liver. The different hypothesis relating to the mechanism of the encephalopathy and the usefulness of such a procedure are discussed: filtration of ammonia, free fatty-acids, role of amino-acids and possible polypeptides.

Adult↗