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Biomedical subjects

F Darnis

Publications and source records attributed to F Darnis.

At least 73 records · Page 4Linked to original sources
PubMed1979

[Cholestatic hepatitis during treatment with I.N.H. and rifampicin: arguments in favour of the hepatotoxicity of rifampicin (author's transl)].

It is generally accepted that hepatitis occurring during treatment with INH and rifampicine results from the hepatotoxicity of INH metabolites. A case is reported of cholestatic hepatitis occurring during such treatment, in which there was a previous history of an isolated hepatic affection. The administration of INH and rifampicin caused cholestasis alone, which reoccurred after rifampicin administration only. No immuno-allergic phenomenon has been shown to be involved in rifampicin toxicity. This observation suggests that rifampicin may be hepatotoxic itself, especially in patients with previous hepatic affections.

Aged↗
PubMed1978

[The "e" antigen system in HBs antigen carriers (author's transl)].

Antigen e and its antibody were sought by radial immunodiffusion in 86 carriers of HBs antigen observed over a period of one year. The antigen was found in 3 cases out of 30 with acute viral hepatitis, 11 cases out of 33 with chronic active hepatitis, 1 case out of 6 with chronic persistent hepatitis and 1 out of 6 healthy carriers. It was not found in the serum of 6 patients with fulminating hepatitis. The presence of antigen e is associated with high titers of circulating HBs antigens (p less than 0,001). In this group, no difference in the course of the disease was found in cases of chronic active hepatitis with HBs antigen, according to the presence or absence of antigen e or its antibody.

Acute Disease↗
PubMed1978

Treatment of encephalopathy during fulminant hepatic failure by haemodialysis with high permeability membrane.

Forty-one patients with fulminant hepatic failure and coma underwent 180 periods of haemodialysis with polyacrylonitrile membrane (AN 69 HD). Hepatic failure was due to viral hepatitis in 40 and drugs in one. Total recovery of consciousness occurred in 17 patients (43.6%), and partial in seven (17.9%)--that is, an overall figure of 61.5%. Regain of consciousness was not related to liver regeneration as assessed by levels of factor V and hepatocyte volume fraction. At the time of the first haemodialysis, neurological status was significantly impaired in the patients who could not be aroused. Mean duration of coma grade IV averaged 6.1 +/- 4.3 days and mean duration of illness until death or decerebration 8.6 +/- 8.3 days. Of the 17 patients who totally regained consciousness, nine recovered and eight died (three from intercurrent complications and five with no liver regeneration).

Acrylonitrile↗