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Biomedical subjects

F Cesselin

Publications and source records attributed to F Cesselin.

151 records · Page 9Linked to original sources
PubMedDate not supplied

[Annual and circadian rhythms in plasma testosterone of five healthy young male Parisians (author's transl)].

Every other month, during the course of 14 months, the circadian rhythm in plasma testosterone (among others variables) of 5 healthy males (26 to 32 years) was documented. Subjects' synchronization : light-on at 07 +/- 1 hr; light-off at 23hr +/- 1.5 hr all the year long. Blood sampling 4-hourly, at fixed clock hours during 28 hrs, for radioimmunologic testosterone determinations. The cosinor method was used for statistical analyses. An annual rhythm in the testosterone 24-hr mean is detected (p less than 0.025) with a peak in October (from 16 July to 26 December, with 95% confidence limits). Annual mean (+/- 1 SE) - 759 (+/- 26)ng/100 ml. Peak-through difference = 107 ng/100 ml (from 106 to 290 with 95% confidence limits). The timing of the testosterone circadian peak, in the 24 hr-scale varies also in the course of the year. The peak is found around 08(00) in May and around 14(00) in November, this phase-shift being statistically significant (p less than 0.05). The sexual activity (daily self-recording) also has an annual rhythm with a peak in October.

Adult↗
PubMedDate not supplied

[Prolactin-secreting adenomas in males. Study of the hypophyseal-gonadal axis].

The pituitary gonadal-axis has been studied in 25 cases of PRL-secreting adenomas in men. Besides impotence, infertility, arrest or lack of puberty may be observed, basal levels of LH and FSH are in the low normal range but a weak increase of LH is observed after LH-RH. Testosterone (T) levels are low in most of the patients and only normal in 5. In two cases with actively secreting-PRL adenomas, normal circadian rhythms of T and PRL are abolished. After CB 154 treatment, an improvement of the clinical and biological symptoms is observed in 8 out of 10 men. An increase of LH response to LH-RH under CB 154 is obtained in 5 cases. This is in favour of a functional effect of the hyperprolactinemia on the pituitary.

Adenoma↗
PubMedDate not supplied

[Determination of pituitary hormones in cerebrospinal fluid in normal subjects and in hypothalamo-pituitary diseases. Secreting or non-secreting pituitary adenoma, empty sella syndrome, hypothalamic syndromes].

Cerebrospinal fluid (CSF) and serum concentrations of TSH, ACTH, FSH, LH, GH and PRL were measured simultaneously in 34 subjects divided into 3 groups: I--12 normal subjects (6 males and 6 females); II--12 prolactin adenomas (3 males and 9 females); III--5 empty sella syndromes; 3 hypothalamic disorders; 1 chromophobe adenoma; 1 pituitary dwarfism. It is concluded that:--pituitary hormones are the normal constituents of CSF but the level can be undetectable and in any case lower than the serum level; --there is a positive correlation between serum and CSF concentration of PRL when serum PRL is higher than 20 ng/ml, indicating that the CSF level is influenced by serum level; --in prolactin adenomas only prolactin is elevated in the CSF; --there is no correlation between the high level of CSF-PRL and a suprasellar extension of the adenoma.

Adenoma↗
PubMedDate not supplied

[Prolactin secretion and synthesis by human somatotropin adenomas: in vitro effect of somatostatin (SRIF) (author's transl)].

Human somatotropin secreting adenomas removed from acromegalic patients were submitted to organ culture for periods of up 1 to 4 hours and 1 to 2 weeks. Prolactin (PRL) secretion increased in most of the experiments during the different culture times while growth hormone (GH) secretion decreased slowly in some of them. After incorporation of 3H leucine, 3H GH and 3H PRL were obtained in short and long term organ culture giving evidence for "de novo" synthesis. SRIF inhibited PRL as well as GH secretion after 1 to 4 hours incubation.

Acromegaly↗