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Biomedical subjects

F Capani

Publications and source records attributed to F Capani.

At least 91 records · Page 5Linked to original sources

[Treatment of unstable diabetes by continuous subcutaneous infusion of insulin].

In a group of seven brittle diabetic males, hospitalized, two kind of treatment has been compared: conventional insulin therapy (three daily injections) versus continuous subcutaneous insulin infusion. A strike improvement of metabolic control has been reached with the latter procedure. It is concluded that this new type of treatment seems very useful in brittle diabetics. The possible benefit on diabetic complications remains to be investigated.

Adult↗

[Circadian rhythm of retinal critical fusion frequency (CFF)].

The measure of the fusion critical Frequency investigates the cerebral and retinal blood circulation. It has been carried out by means of Modugno-Rispoli apparatus in 11 subjects with a circadian procedure. A circadian rhythm was detected in right eye, left eye and both eyes with acrophases respectively at 11,57, 11.19 and 11.31 hrs. It is concluded that the existence of the oscillations of the cerebral vascular efficiency could have a practical implications in both diagnosis and therapy of related disease.

Adult↗

[Effects of a "single-meal" low calorie diet on the circadian variation of serum cortisol, insulin and somatotropin and urinary excretion of catecholamines].

Four obese patients were given a single-meal diet for two periods of three days each. Blood samples were drawn every four hours for serum determinations of growthormone, cortisol and insulin. At same times urinary samples for urinary cathecholamines determination were collected. Cortisolemia showed a firm circadian rhythm in both regimens: there was a marked over-lap of the two confidences ellipsis so we could conclude for the independence of cortisol rhythm whith both regimes, but there occurred a significant difference in the acrofases between the two regimens. This could mean that meal-timing can play a major role in syncronizing catecholamines urinary excretion as far as subjects in supine position are concerned. No circadian rhythm was detected either in serum insulin or in HGH values.

Catecholamines↗

[Modifications of the water balance and urinary excretion of sodium and potassium in obese subjects on a "single-meal" low-calorie diet].

Four obese patients were given a single-meal diet (684 kcal.) for two periods of three days each. Water-loss, according to Peter-Passmore formula, and urinary sodium and potassium excretion were measured at 4-hours intervals. A water-loss greater in the first than in the second and in the third day in both periods and a strong linear correlation between water-loss and sodium urinary excretion were found. Furthermore a circadian rhythm either is sodium or in potassium urinary excretion not modifiable by meal timing with both regiment was detected.

Adult↗

[Variations in carbohydrate, lipid and protein oxidation evaluated by indirect calorimetry in obese subjects on a "single-meal" low-calorie diet].

Four obese patients were given a single-meal diet (Kcal, 684) for two periods of three days each. CO2 production and 02 consumption were measured every four hours for 30'. At the same times urine samples were collected for nitrogen evaluations. By Consolatio's formulas the amount of carbohydrates, lipids and proteins oxidated in the three days of both periods was calculated. No changes in carbohydrate and lipid oxidation rates were found during the three days with meal at h.10, while a progressive increase in lipid oxidation and a progressive decrease in carbohydrates oxidation could be observed with meal at h. 18. No change with both regimes could be observed in protein oxidation. Furthermore a circadian rhythm of lipid and carbohydrate oxidation with both regimens was observed, while protein oxidation showed a circadian rhythm only with meal at h.10.

Adult↗

[Chronobiological pattern size of cardiac rhythm (author's transl)].

The basic knowledge of statistical methods in chronobiology are exposed, for the analysis of chronobiological features of cardiac rhythm. The cosinor's method, with definition of chronobiological parameters (acrophase, mesor and amplitude) allows a microscopic approach to study of biological rhythms. The AA. relate some chronobiological studies: a) on heart rate in normal subjects and in patients with myocardial infarction (MI); b) on premature ventricular beats in MI; c) on atrial and ventricular rates in complete AV block. These results demonstrate that there is an evident circadian rhythmicity for all analyzed parameters. The AA. analyse the physiological and clinical meaning of the chronobiological approach to cardiac rhythm for the chronopharmacological and pathophysiological studies and suggests the implications in pathology of adaptation to shift work.

Circadian Rhythm↗

[Preliminary results of an epidemiological survey for diabetes].

Mass screening for diabetes in a factory employing 464 subjects by means of a 75 g oral glucose tolerance test and measurement of blood sugar with Dextrosix reagent strips read on a reflectance meter is reported. Values of 120 mg% or over were noted in 10.34% and values in the range 110 to 120 mg% in 7.76%.

Adult↗

Circadian rhythm of insulin-induced hypoglycemia in man.

Four healthy men were given an insulin tolerance test (0.1 IU/kg BW) six times in different days at the following clock hours: 0400 h, 0800h, 1200 h, 1600 h, 2000 h, and 2400 h, in random order. Four days separated two consecutive tests. The glucose disappearance rate (K value) was calculated for each test between 5 min and 25 min after iv injection of insulin. The statistical evaluation by Cosinor test showed a statistically significant circadian rhythm for the hypoglycemic action of exogenous insulin with a peak at 1030 h (95% condifence limits: 0830 to 1430 h).

Adult↗