Search PubMed⌕ Search

Biomedical subjects

F C Powell

Publications and source records attributed to F C Powell.

At least 55 records · Page 3Linked to original sources

Odontoid fractures in elderly patients.

This retrospective analysis describes the clinical characteristics, treatment, and outcome of 19 patients aged 80 years or older with odontoid fractures. The fractures were due to falls in 15 patients (78.9%) and were associated with motor-vehicle accidents in four. Type III fractures were seen in three patients and type II fractures in 16. No patient suffered a neurological injury associated with the fracture. Five patients (26.3%) died during hospitalization; factors contributing to their death included prolonged bed rest, associated injuries, and concomitant medical illnesses. The mean follow-up period in the remaining 14 patients was 28.8 months (range 5 to 72 months). Eight patients with a posterior displacement of 5 mm or less were treated with cervical immobilization, three of whom showed a stable non-union of the fracture site at follow-up review. One patient with 10-mm displacement refused operative treatment. Three of the patients without surgical treatment subsequently died from unrelated causes; all remaining patients resumed their routine activity. Five patients with displacement of 5 mm or greater and instability at the fracture site were treated with posterior cervical fusion of C1-2 using wire and autologous iliac bone grafts. In this group, no operative morbidity or mortality occurred and stable constructs developed in all patients; one patient died from an unrelated cause during the follow-up period and the other patients resumed their normal activity. Prolonged bed rest caused respiratory complications in two of six patients who survived initial hospitalization; two of three patients treated with rigid immobilization developed complications that required alternative treatments.

Aged↗

HLA typing in Irish psoriatics.

Histocompatibility antigens were determined in 93 unrelated Irish psoriatic patients. The results were compared with the HLA profiles of 253 healthy unrelated Irish controls. There was a statistically significant increase in HLA B17 (P < 0.0001), B13 (P = 0.02), and B27 (P = 0.015) among the psoriatic patients. The frequency of HLAB8 (P = 0.002) and HLA B12 (P = 0.001) was lower than expected. When the subgroup of patients with psoriatic arthritis was evaluated separately, it was noted that the increase in HLAB27 was highly statistically significant (P < 0.0001). The relative risks of an Irish patient carrying the major psoriasis associated alleles of developing psoriasis are documented;-possession of the HLA B17 and B13 antigens conferring a risk of developing psoriasis vulgaris of 6.08 and 2.9 respectively. Further values for psoriatic subsets are presented. This is the first report of HLA typing in an Irish psoriatic population. The findings are discussed and compared with other population groups.

Arthritis, Psoriatic↗

Schirmer testing for dry eyes in patients with rosacea.

BACKGROUND: Dry eyes have been reported in a significantly greater number of patients with ocular rosacea than in control subjects. OBJECTIVE: Our purpose was to assess the incidence of dry eyes in patients with cutaneous rosacea and to compare this with a control population. METHODS: With the use of the Schirmer test without anesthesia, the amount of aqueous tear secretion of 32 consecutive patients (16 women, 16 men) with rosacea was compared with that of 32 psoriasis patients (16 women, 16 men) without rosacea who served as age- and sex-matched controls. Two criteria, 5 mm and 8 mm of strip wetting, were used to indicate the lower limit of normal aqueous tear secretion. RESULTS: Of rosacea patients, 56.3% had less than 8 mm of strip wetting compared with 25% of control patients (p less than 0.02). Of rosacea patients, 40.6% had less than 5 mm of strip wetting compared with 18.75% of controls (p less than 0.10). CONCLUSION: The results of this study suggest that dry eyes occur frequently in rosacea. It is important that dermatologists and ophthalmologists be aware of the frequency of dry eyes in rosacea, so that patients are investigated and appropriate therapy can be provided.

Adult↗

Pyoderma gangrenosum, polycythemia rubra vera, and the development of leukemia.

A patient with long-standing, well-controlled polycythemia rubra vera developed recurrent episodes of bullous pyoderma gangrenosum followed by the transformation of his hematologic disease into a rapidly progressive acute myeloid leukemia. This case, together with previously described patients, indicates that the appearance of bullous pyoderma gangrenosum in a patient with polycythemia rubra vera is often of ominous prognostic significance.

Humans↗

Rural and urban elderly construe health differently.

Samples of people aged 65 or older (N = 396) living in the metropolitan Omaha area and in the rural Sandhills counties of central and western Nebraska completed an instrument to assess health satisfaction, health behaviors, and attitudes toward health care. Few intergroup differences were found that could be attributed to the area of residence. However, factor analysis and item analysis of the attitudes toward health items indicated that older respondents in rural areas may have very different perceptions of health in general and of health care services in particular than those of elderly urban residents.

Aged↗

Generalized elastosis perforans serpiginosa in Down's syndrome.

Elastosis perforans serpiginosa is a rare disorder of epidermal perforation characterized by the extrusion of dermal elastic tissue through the epidermis. Its aetiology is unknown, but there is histological and biochemical evidence of an abnormality of elastic tissue. Three forms of elastosis perforans serpiginosa exist. It may be either idiopathic, iatrogenic, or, in approximately one quarter of cases, associated with certain genetically determined disorders of connective tissue. Cutaneous lesions appear between the ages of 6 and 20 years, and persist for 6 months to 5 years. They may be confined to one anatomic area, or less frequently are disseminated. We review the case of a 28-year-old woman with recent onset of unusually extensive elastosis perforans serpiginosa with co-existing Down's syndrome and (secondary) sclerosing cholangitis.

Adult↗

Familial non-diabetic necrobiosis lipoidica.

Necrobiosis lipoidica (NL) is a cutaneous disorder with distinctive clinical and morphologic characteristics. It is associated with diabetes mellitus in two thirds of cases. The aetiology and pathogenesis of NL are unknown but familial cases of NL seem to be extremely rare. We report the occurrence of NL in two sisters with normal glucose tolerance.

Biopsy↗

Polymorphic light eruption with contact and photocontact allergy.

We report a patient with long-standing polymorphic light eruption (PLE) who developed a photocontact allergy to mexenone and several contact allergies. The occurrence of multiple contact and photocontact allergies in PLE and the possible relationship of such allergies to the pathogenesis of PLE are discussed.

Aged↗

Necrobiosis lipoidica and sarcoidosis.

We report the case of a female patient with necrobiosis lipoidica of the lower legs and coexistent systemic and cutaneous sarcoidosis. We review the six previously reported patients with coexisting necrobiosis lipoidica and sarcoidosis. The associations between the granulomatous disorders of the skin, especially necrobiosis lipoidica, sarcoidosis and granuloma annulare, are discussed. The common pathogenetic features of these disorders are reviewed.

Female↗

Medical students' attitudes towards ageing and death: a cross-sequential study.

This study presents an analysis of possible changes in attitudes towards older persons and in attitudes towards personal death anxiety that might occur over the course of undergraduate medical education. Three entering classes of medical students at a university in the Mid-western United States completed an attitudes towards old people scale, a death anxiety scale, and a standard personality inventory. As graduating seniors, they again completed the attitudes towards old people scale and the death anxiety scale. Significant changes did not occur. In comparison with baseline data from a group of 212 university graduate students in the USA, these 234 medical undergraduates had significantly more positive attitudes towards the aged; in another comparison, their death anxiety was significantly lower than a group of 599 from the general population. Implications are discussed.

Adult↗

Epidermolysis bullosa and aplasia cutis.

Recessive dystrophic epidermolysis bullosa with aplasia cutis occurring in a male infant is described. The association of these two rare conditions is reviewed. Reports of the concurrence of large areas of congenital absence of skin, particularly on the lower limbs, in patients with several different types of epidermolysis bullosa suggest that areas of congenital absence of skin in these patients are an initial manifestation of the bullous disease rather than a distinctive entity.

Epidermolysis Bullosa Dystrophica↗

Extramammary Paget's disease and prostatic carcinoma.

A patient with perianal extramammary Paget's disease (EMPD) occurring simultaneously with prostatic adenocarcinoma is presented. Four previously reported cases of genital EMPD associated with prostatic carcinoma are reviewed. The use of immunohistologic techniques to help establish the diagnosis in some cases, and the relationship of EMPD to underlying adenocarcinoma of sweat glands and of the lower urinary and gastrointestinal tracts is discussed. The importance of a directed search for internal malignancy in the individual patient with EMPD is emphasised.

Adenocarcinoma↗