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Biomedical subjects

F Bacin

Publications and source records attributed to F Bacin.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Prognostic study of malignant melanoma of the uvea treated by enucleation].

In order to evaluate the clinical and histopathologic prognosis indicators of uveal melanomas treated with enucleation, 59 patients, followed up during 1 to 18 years were included in a retrospective study. Kaplan Meier survival curves were constructed and compared using the log rank test. The overall 5 and 10 years probabilities of survival were 74.9% and 48.5% respectively. Metastases were, or might have been, responsible for death in 83.3% of the cases. The median survival was 4 years 9 months (range less than 1 to 11 years). Fifty five per cent of the metastases occurred within 4 years of the enucleation and 90% within 8 years. For the patients with spindle cell melanomas, the 5 year probability of survival was 90% against 38% for the patients with epithelioid cell tumors. The median time to tumor related death was 5 years for the first group against 3 years 8 months for the second. The analysis of our data demonstrated the tumor volume to be a statistically significant clinical prognosis indicator. The following histopathologic parameters were also statistically significant prognosis indicators: the cell type (p less than or equal to 0.001), the mitotic activity, the state of the sclera, the presence of blood lakes. Statistical adjustments and determination of the instantaneous relative risk of death showed the histopathologic factors, specially the cell type, to be the most important indicators.

Adult↗
PubMed1985

[Intraocular fibrosis after perforating injury of the posterior segment. Experimental study].

Double perforating injuries and linear wounds were produced in the posterior segment of the rabbit eye in order to study post-traumatic intraocular proliferation. After observation for one month, the animals were sacrificed and the eyes treated for histologic examination. Transvitreous strands and preretinal membranes slowly developed, sometimes inducing traction retinal detachment. Histologic studies demonstrated the new-formed tissue to be fibrovascular, mainly containing collagenous fibers and fibroblast-like cells. This fibroblastic proliferation closed the wound through the ocular membranes and invaded the vitreous using vitreous fibers as a scaffold. The authors discuss the signification of this results comparing them to literature data on different animals and on man.

Animals↗