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Biomedical subjects

E Zimmermann

Publications and source records attributed to E Zimmermann.

At least 91 records · Page 5Linked to original sources
PubMed1980

Modulation of cat monosynaptic reflexes by substance P.

Substance P (SP) applied by iontophoresis at different current strengths to single motoneurons of cat spinal cord did not cause these units to discharge. SP produced a gradual and prolonged change in synaptic excitability as measured by response to dorsal root stimulation. The effect outlasted application of SP. The lowest effective dose of SP diminished motoneuron response to dorsal root stimulation (inhibitory modulation). Doses 2-4 times as great enhanced the response to dorsal root stimulation (facilitatory modulation) without causing the motoneuron to discharge spontaneously. These observations suggest that one physiological role of SP is modulation of synaptic transmission, i.e. alteration of efficacy of transmission without acting as a primary transmitter at the postsynaptic membrane.

Animals↗
PubMed1979

Lipid metabolism in uremic and nonuremic acidosis.

In bilaterally nephrectomized rats and in normal rats treated with 0.1 N HCl elevated levels of plasma total glycerol and lowered FFA and free glycerol are observed after a period of 25 h of starvation. In both cases the removal of intravenous lipid loads is slowed down, plasma LA is decreased after starvation and after lipid loads. The bicarbonate treatment of nephrectomized rats tends to normalize the plasma lipid levels and LA as well as the removal of intravenous lipid loads. The etiological importance of acidosis in uremic hypertriglyceridemia and possible clinical significance is pointed out.

Acidosis↗
PubMed1979

[Variations in the muscular insertion, the course and elasticity of the muscles in people suffering from squint (author's transl)].

Variations in the area of the insertions of the rectus muscles are quite often observed. We have been paying more attention to these changes during the past year, and therefore we measured the distance of insertion from the corneal limbus during 310 squint operations. Furthermore we noted the width of the tendon at the insertion, atypical forms of insertions and finally we tried to evaluate the factor of muscular elasticity. The findings are as follows: 1. The arithmetical mean of the distance of insertion from the limbus was slightly less than cited in literature on this subject. It was not unusual to find variations of up to 4mm, even between the same muscles of both eyes. This seems to have little influence on the primary position and on the success of surgical interventions; when they do not exceed the measures cited in our paper. The relatively great area of contact will balance these variations. 2. We could not find a correlation between anomalies of refraction and the distance of insertions of the limbus. The insertions of higher degree hyperopia was not closer to the limbus. 3. The arithmetical mean of the width of tendon conformed to the values as shown in the literature. A range up to 8 mm for the medial rectus, up to 5,5 mm for the lateral rectus and up to 2,5 mm for the vertical rectus were observed. 4. We could see variations of the insertions: upward and downward and furthermore different lines of insertions: arched and step-like. These anomalies were found 52 times among the 310 muscles measured. 5. An increased muscular rigidity was felt in 56 medial rectus and in 13 lateral rectus muscels. In 21 cases the course of the horizontal muscles was atypical, i.e., they ran from below diagonally out of the orbita.

Child, Preschool↗
PubMed1979

Protracted behavioral effects of neonatal morphine-pellet implantation in male rats.

Male rat pups (Charles Rivers CD albino strain) were implanted subcutaneously with a morphine (M), placebo (P), or no pellet (NP) on Day 5 or 11 of postnatal life. Body weights of both Day 5 and 11 drug-treated males were depressed below those of controls through Day 63 (p < 0.01). On Day 72, compared to P and NP controls, M-treated males showed impaired learning in a Lashley III maze. Day 5, but not Day 11 drug-treated animals showed greater activity-wheel behavior (p < 0.01) than controls on Days 85--86, and less suppression (p < 0.025) of a conditioned emotional response on Day 145. On Day 150, Day 5 M-treated animals showed a reduced steroid response (p < 0.05) to a challenge dose of M (18 mg/kg), suggesting protracted tolerance to the pituitary-adrenal activating effects of M. Members of each treatment group were successfully bred with females on Day 90; no group differences were found in litter size, sex ratios, or birth weights of the offspring. The results of this study indicate that early exposure to M causes long-term impairment of several behaviors in male rats.

Animals↗
PubMed1978

[Recurrence of pseudotumour cerebri (intracranial hypertension) after renal transplantation (author's transl)].

The case report is presented of a 24-year-old male who developed the clinical signs and syptoms of pseudotumour cerebri (intracranial hypertension) twice during the course of protracted rejection 1 and 4 months after renal transplantation. Clinically, headache, nausea, hypertensive crisis and, finally, severe coma with an acute mid-brain syndrome was observed. Neurologically a mild left-sided hemiparesis was found on the second occasion. Examination of the fundi revealed bilateral papilloedema. Electroencephalograms showed pathological changes of a diffuse nature, later followed by abnormal delta range activity in the right frontotemporal projection. The withdrawal of corticosteroid therapy may have been responsible for the pseudotumour cerebri in this case.

Adult↗
PubMed1977

An effect of beta-melanocyte stimulating hormone (beta-MSH) on alpha-motoneurones of cat spinal cord.

Actions of beta-MSH and of melatonin on the recovery cycle of single spinal neurones were studied in the decerebrate-spinal cat. beta-MSH facilitated the rate of post-excitation recovery of alpha-motoneurones and some internuncial neurones, and melatonin inhibited the rate of post-excitation recovery. These observations provide additional evidence that beta-MSH functions in the nervous system as a modulator, and may help explain actions of beta-MSH in modifying acquisition of conditioned avoidance responses as well as its interaction with drugs such as morphine.

Animals↗