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Biomedical subjects

E Yourassowsky

Publications and source records attributed to E Yourassowsky.

At least 145 records · Page 8Linked to original sources
PubMed1976

[Investigations on production of spheroplasts in different species of the genus Haemophilus isolated from pathological material of the respiratory tract (author's transl)].

One hundred and fifty three strains belonging to 5 different species of the Genus haemophilus isolated from pathological material of the respiratory tract, have been submitted to the action of inductive agents. Under their influence, all those strains, and consequently all the species examined undergo morphological changes and give rise to spheroplasts. The present work demonstrates that this phenomenon not only belongs to Haemophilus influenzae but probably is a common characteristic of the Genus Haemophilus.

Culture Media↗
PubMed1976

Antibacterial activity of ribostamycin on Enterobacteriaceae.

The study of the inhibitory activity of ribostamvcin (Vistamycin), an antibiotic derived from Streptomyces ribosidificus, on 161 strains of Gram-negative bacilli shows that the antibacterial spectrum of this antibiotic is identical to that of kanamycin. If controlled clinical studies confirm that ribostamycin is less toxic than kanamycin on the otovestibular system, this antibiotic will constitute a real therapeutic advance.

Amikacin↗
PubMed1975

Antistaphylococcal activity of sisomicin and four other aminoglycosides against strains sensitive and resistant to methicillin.

Five aminoglycosides were tested for inhibitory activity on 91 strains of Staphylococcus aureus, 39 of which were methicillin-resistant. The antistaphylococcal activity of these antibiotics was independent of the methicillin-resistance. Their order of decreasing effectiveness was: gentamicin greater than tobramycin = sisomicin greater than amikacin greater than kanamycin. Resistant strains were only found for the latter.

Aminoglycosides↗
PubMed1975

[Cefazolin].

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Cefazolin↗
PubMed1975

Paradoxical action of penicillin G on Staphylococcus aureus: a time study of the effect of a zonal antibiotic concentration gradient on bacterial growth.

The killing rate of a zonal concentration gradient of penicillin G on Staphylococcus aureus was studied by using a previously described triple-layer technique, enzymatic inactivation of the antibiotic, and an automatic image analyzer. This gradient determines a target image, whose center is the reservoir of antibiotic (constituted by a paper disk containing 100 U of penicillin G) and whose successive concentric zones are: a zone of slow bactericidal activity (corresponding to high levels of penicillin G), a zone of maximal bactericidal activity (corresponding to optimal levels of penicillin G), and a zone of overgrowth situated in front of the antibiotic wave.

Culture Media↗
PubMed1975

Comparison of the in vitro activities of BB-K8 and three other aminoglycosides against 215 strains of Pseudomonas and Enterobacteriaceae with variable sensitivity to kanamycin and gentamicin.

215 gram-negative bacilli isolated from clinical materials were tested in vitro against BB-K8 by means of disc diffusion and agar dilution tests; the strains included 40 isolates resistant to gentamicin. Approximately 90% of the strains were inhibited by 3.12 mug/ml or less BB-K8. This antibiotic exhibited a comparable activity, although somewhat inferior, to that of gentamicin, against organisms sensitive to gentamicin. It was considrably more active than gentamicin, and comparable to tobramycin, against the isolates of Klebsiella-Enterobacter-Serratia spp. resistant to gentamicin, but less active than tobramycin against 11 strains of Pseudomonas resistant to gentamicin.

Amikacin↗
PubMed1975

Comparative in vitro acitvity of chloramphenicol and thiamphenicol on common aerobic and anaerobic gram-negative bacilli(Salmonella and Shigella excluded).

The antibacterial activity of thiamphenicol was compared to that of chloramphenicol against 313 strains of gram-negative bacilli isolated from various clinical specimens. These two antiboitics were equally active against the 106 isolates of Haemophilus MIC equals 0.1 minus 1.56 mu g/ml) and against 40 strains of Bacteroides fragilis (almost all strains being inhibited by 12.5 mug/ml of the two drugs). In contrast, when compared with chloramphenicol, 2-16 times as much of thiamphenicol was required to inhibit Enterobacteriacae, making prediction of the susceptibility of these strains to thiamphenicol on the basis of chloramphenicol testing alone likely to be hazardous. Disc diffusion test using 30-mug discs and 12 mm as cut-off point was a reliable technique to determine susceptibility of bacteria either to chloramphenicol or thiamphenicol. When thiamphenicol discs of greater potency (50 mug) were employed, many strains exhibited wide zones of inhibition although most of them were resistant by the agar dilution method (MIC is greater than 12.5 mug/ml). This practice is not advisable for testing organisms isolated outside of the urinary tract.

Anti-Bacterial Agents↗
PubMed1975

Comparative inhibitory activity of BL-S640 and two other cephalosporins.

In vitro antibacterial activity of BL-S640 was compared to that of cephalothin and cephalexin against Gram-negative and Gram-positive bacteria isolated from clinical specimens. BL-S640 demonstrated the best activity on nearly all microbial species studied, except for Haemophilus influenzae and Diplococcus pneumoniae against which cephalothin was slightly more active.

Cephalexin↗
PubMed1975

In vitro bacteriostatic and bactericidal activities of 7 cephalosporin antibiotics on Haemophilus influenzae.

A total of 30 recently isolated strains of Haemophilus influenzae were tested for in vitro susceptibility to seven cephalosporins. In order of bacteriostatic effectiveness, the in vitro activity of the antibiotics studied was: cephapirin (median MIC = 0.78 mcg/ml), cephalothin (median MIC = 1.56 mcg/ml), cefazolin (median MIC: 1.56 mcg/ml), cephaloridine (median MIC = 3.12 mcg/ml), cefoxitin (median MIC = 3.12 mcg/ml), cephradine (median MIC = 12.5 mcg/ml) and cephalexin (median MIC = 25 mcg/ml). The bactericidal effectiveness of the seven compounds was studied against one of these strains. No drug was able to kill the selected strain in less than 6 hrs, even at 100 mcg per ml. Cefoxitin exhibited the best bactericidal effects, closely followed by cefazolin and cephapirin.

Cefazolin↗
PubMed1975

[Klebsiella septicemia. Epidemiologic aspects based on antigenic and biochemical studies of strains].

50 strains of Klebsiella pneumoniae were isolated by blood cultures at Brugmann Hospital (Brussels) between 1967 and 1971. The biochemical and antigenic characteristics of the strains and their sensitivity to antibiotics were determined for epidemiological purposes. With the exception of the strains found in an hemodialysis unit, where the study showed the existence of an epidemic focus caused by serotype 28 biotype d, the strains consisted of a large number of capsular serotypes and of biotypes, excluding a single source of contamination for these septicemic infections. There is no relationship between the serotype of the strains and their sensitivity to antibiotics.

Anti-Bacterial Agents↗
PubMed1975

[Cerebromeningeal cryptococcosis. Predisposing role of immunosuppressive therapy in patients with kidney transplants].

Disseminated cryptococcal infection is described in eight patients, seven of them with verified meningeal involvement. Six of the eight patients were recipients of a renal homograft and submitted to the classical immunosuppressive treatment. Consideration is given to predisposing factors and to problems in the clinical, biological and mycological diagnosis. Some comments are presented on the often disappointing results of antifungal therapy of cryptococcal meningitis.

Adult↗