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Biomedical subjects

E Wildhirt

Publications and source records attributed to E Wildhirt.

At least 37 records · Page 2Linked to original sources
PubMed1978

[A peculiar type of chronic persisting hepatitis (author's transl)].

Six cases of persisting hepatitis with a duration of 3 to 9 years are reported. During this time 2--3 acute inflammatory episodes occurred with transaminase levels raised to more than 500 U/l. Icterus did not occur during these attacks. The remaining laboratory parameters which are usually normal in persisting hepatitis (gamma-GT, bromsulfalein) were pathological during the acute attack and later became normal. As the disease progressed after overcoming the attack, the transaminases were only slightly raised in all cases. Laparoscopy and histological examinations of between three and nine punctates gave an unchanged picture of chronic persisting hepatitis. During the acute attack the inflammatory activities in the liver punctates increased, there were also increased single cell necroses. It is suggested that this peculiar type of chronic persisting hepatitis shall be called "acute recurrent persistent hepatitis.".

Adrenocorticotropic Hormone↗
PubMed1978

Simultaneous occurrence of perimembranous glomerulonephritis and glomerular amyloidosis.

The results of electron microscopic examination of renal biopsies from 3 patients with rheumatoid arthritis treated with penicillamine are presented. All 3 patients developed a nephrotic syndrome upon discontinuation of penicillamine therapy. When viewed with the electron microscope, segmental forms of perimembranous glomerulonephritis (Stages I-II of Ehrenreich and Churg) and glomerular renal amyloidosis Grade I-III were observed. In all three cases the nephrotic syndrome was considered to be due to the simultaneous occurrence of the two disease processes. In 2 cases perimembranous glomerulonephritis with immuno-complex-deposits was assumed to be the dominant factor in the causation of the disease, in the other case amyloidosis was the principle abnormality.

Amyloidosis↗
PubMed1978

[Rupture of postoperative adhesions and hemorrhage--a rare complication of peritoneoscopy (author's transl)].

A case report is given of a patient, who had been operated upon because of gall stones before; the gall bladder had not been removed. At a later date peritoneoscopy was planned and gas insufflated into the abdominal cavity in the usual manner; the patient did not complain about anything particular during peritoneoscopy. However adhesions apparently having formed after the earlier operation between the spleen and the abdominal wall did rupture during this procedure leading to a continously oozing hemorrhage from the spleen. At surgery 3 1 of blood were found in the abdominal cavity and splenectomy became unavoidable. This case report is given in order to draw attention to this sort of complication of peritoneoscopy.

Female↗
PubMed1976

[The diagnostic significance of immunoglobulin determination in chronic liver diseases. III. observations of progress (author's transl)].

55 patients with chronic aggressive hepatitis and 20 with liver cirrhosis were observed over a 2-year period. Liver biopsy was performed several times but no immunosuppressive therapy was carried out. In this way a comparison was made between biochemically and histomorphologically demonstrable alterations in the process with the immunoglobulins. Significant agreement between the clinical biochemical and histomorphological activities and the behavior of immunoglobulin can only be concluded from increased activity of the process. But in histological deterioration, no correlation to the immunoglobulins was established, with the exception of IGM.

Adult↗
PubMed1975

[The diagnostic significance of immunoglobulin determination in chronic liver diseases. II. Relationships between immunoglobulin changes and degree of activity (author's transl)].

The relationship between the immunograms and aminotransferases, gamma-GT and AP were examined in 715 patients with hepatobiliary diseases closely confirmed by histomorphological criteria and a series of 60 normal subjects. The normal subjects showed positive relationships. These are largely lacking in acute and protracted courses and in chronic aggressive hepatitis. Only relationships of the individual immunoglobulins between themselves can be demonstrated in the aggressive chronic types. Positive relationships are present between immunograms and aminotransferases, gamma-GT and AP in the group with fatty livers, and so are other highly significant positive relationships in toxic hepatitis and toxic cirrhoses of the liver.

Acute Disease↗
PubMed1975

[The diagnostic significance of immunoglobulin determination in chronic liver diseases. I. Differential diagnostic accuracy of immunoglobulin changes and enzyme activities (author's transl)].

715 patients with hepatobiliary diseases came for examination, who because of the morphological findings are classified in diagnostic groups. The immunoglobulin measurements of IGG, IGA, IGM were determined and assessed in combination with enzymatic investigations of GOT, GPT, AP and GGTP. Typical group-specific changes were only found in primary biliary liver diseases and toxic cirrhoses of the liver, all acute or chronic inflammatory liver diseases could not be separated and by inference from the final diagnosis showed great errors in classification. Data on the raised mean levels of immunoglobulins in the individual diagnostic groups were demonstrable, but the range limits were so widely scattered that their differential diagnostic valence is of no consequence. Immunoglobulins may appear to be of interest for the observation of the course of liver diseases, but they are unsuitable for diagnostic purposes.

Acute Disease↗