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Biomedical subjects

E Wespes

Publications and source records attributed to E Wespes.

At least 73 records · Page 4Linked to original sources
PubMed1988

Study of neuropeptide Y-containing nerve fibers in the human penis.

Neuropeptide Y 1-36 (IR-NPY) immunoreactive nerve-fiber processes have been observed in tunicae of veins and arteries and in smooth muscles of the human penis taken at autopsy or during surgery by use of light- and electron-microscopic immunohistochemical techniques. Numerous IR-NPY nerve fibers were mostly concentrated in the inner part of the adventitia close to the media of the arterial and venous vessels and among the intracavernous smooth muscle cells. IR-NPY nerve fibers were less abundant in veins than in arteries. Positive somata were not observed in the penises. At the ultrastructural level, IR-NPY were localized exclusively in large, dense granules of nerve terminals by means of the postembedding immunogold technique. In the deep dorsal vein, IR-NPY nerve fibers were also located in the media formed by an outer circular and an inner longitudinal layer. In the intracavernous and dorsal arteries, they showed the highest density in the inner part of the adventitia. In the corpora cavernosa and in the corpus spongiosum, IR-NPY nerve processes were intermingled between the smooth-muscle fibers around the sinusoid spaces. IR-NPY nerve fibers were present in the cavernous nerves close to the central arteries. The urethra did not show any IR-NPY-positive nerve fibers. This peculiar distribution of IR-NPY nerve fibers suggested that they could participate in regulating arterial and venous blood flow and intracavernous smooth-muscle tone. NPY may therefore be of importance in some of the mechanisms of penile erection especially during detumescence.

Adolescent↗
PubMed1988

Systemic complication of intracavernous papaverine injection in patients with venous leakage.

Intracavernous papaverine injection is often used in the diagnosis and treatment of male impotence. Prolonged erection and/or priapism are well known local complications. Systemic side-effects characterized by discomfort and dizziness due to rapid escape of the drug into the vascular circulation also can occur in patients with venous leakage. Thus, venous leakage should be ruled out prior to intracavernous injection of papaverine in the treatment of impotence. Ligation of the deep dorsal vein and the small veins around the tunica albuginea will lessen the problem.

Erectile Dysfunction↗
PubMed1988

Opacification of the glans penis during cavernosography.

Cavernosography and cavernometry were performed in 150 impotent patients and 10 normal potent volunteers. Opacification of the glans penis was noted in 5 normal volunteers, while among the impotent patients it was noted in 53 per cent of those with venous leakage and in 36 per cent of those without leakage. We believe that opacification of the glans during cavernosography must be regarded as a normal variant rather than as a sign of pathological shunts between the glans and the corpora cavernosa.

Adult↗
PubMed1987

The effect of papaverine on arterial and venous hemodynamics of erection.

The aim of this study was to establish how much of the erectogenic effect of papaverine is due to arterial dilatation and how much to venous obstruction during artificial erection. Three consecutive cavernosographies were done on each of 10 psychogenic impotent patients: a baseline run without papaverine; a run with papaverine (60 mg. intracavernously) after occlusion of arterial supply to the corpora cavernosa with balloon catheters inflated at the origin of the hypogastric arteries; and a third run after restoring arterial blood supply to the corpora. The measured flow rates indicated that during cavernosography in papaverine-induced erection, the major effect of papaverine is to increase the resistance to venous outflow from the corpora cavernosa.

Adult↗
PubMed1987

The erectile angle: objective criterion to evaluate the papaverine test in impotence.

Intracavernous papaverine injection may be the first diagnostic step in the assessment of the impotent patient. However, the appreciation of its effect must rely on the evaluation of penile rigidity. Since measurement of rigidity requires a sophisticated procedure that may not be available to the majority of practitioners, we attempted to find a simple and objective method to evaluate the results of this common test. We tested 50 patients complaining of impotence with intracavernous injection of 60 mg. papaverine. The length and circumference of the penis were measured before and after papaverine injection. The rigidity was determined by measuring the angle between the penis and the legs with the patient in the standing position. Afterwards, each patient underwent vascular (Doppler ultrasound and cavernometry) and neurological examinations. A total of 27 patients with no vascular abnormalities had an erectile angle of 96 degrees (range 90 to 130 degrees), while 23 patients had some vascular disorders (9 arterial lesions, 8 venous leakage and 6 combined lesions) and an erectile angle of 36 degrees (range 0 to 60 degrees). There was no significant difference between the groups in the increase of length and circumference of the penis after intracavernous injection of papaverine. The papaverine test can distinguish between patients with vascular and psychogenic problems. A negative papaverine test associated with a normal Doppler examination is characteristic of venous leakage. Measurement of the erectile angle after intracavernous injection of papaverine with the patient in the standing position is a simple, objective and reliable method to evaluate patients with vascular impotence.

Adult↗
PubMed1987

Penile deep dorsal vein cushions and erection.

During surgical treatment of impotence due to venous leakage, the deep dorsal veins from 10 patients were resected and studied histologically to see if any morphological anomaly could be implicated in the physiopathological mechanism of venous leakage. Normal venous cushions were present in these veins similar to those observed in the deep dorsal veins of patients with normal erections. Their function and possible deterioration are discussed.

Adult↗
PubMed1987

Fracture of the penis: conservative versus surgical treatment.

Four patients with penile rupture were treated by a surgical procedure without any complications. Three patients with a history of penile fracture consulted for sexual problems; 2 of them had a penile curvature and the other presented an arteriovenous fistula. We discuss immediate treatment of penis rupture by comparing our results and those reported in the literature.

Adult↗
PubMed1986

Cabanas approach: is sentinel node biopsy reliable for staging penile carcinoma?

In 1977 Cabanas proposed biopsy of a sentinel node which is considered the primary site of metastasis from penile carcinoma. If this node is not invaded by tumor, no further surgical treatment is necessary. We report on 2 patients in whom results of bilateral sentinel lymph node biopsies were negative and in whom pelvic lymph node metastasis developed within one year.

Aged↗
PubMed1986

Ileocaecocystoplasty in urinary tract reconstruction in children.

Ten children have undergone lower urinary tract reconstruction by ileocaecocystoplasty. Four patients had previously been diverted and the other six were reconstructed because of intractable incontinence or deteriorating renal function. Continence was primarily achieved in eight patients and renal function improved or remained stable in all 10. Reflux was prevented by a plicated ileocaecal valve in five of eight patients. Continued pharmacological manipulation, intermittent self catheterisation and secondary surgical intervention were frequently necessary in these patients who required careful counselling and follow-up.

Adolescent↗
PubMed1986

Pharmacocavernometry-cavernography in impotence.

Cavernometry and cavernography before and after injection of papaverine into the corpus cavernosum were performed in five psychogenically impotent patients and in 30 patients with organic impotence demonstrated by penile plethysmography. The flow necessary to provoke an erection in the psychogenic patients and in the 20 patients without venous leakage ranged from 80 to 120 ml/min and was reduced to 20 to 65 ml/min after injection of papaverine. In the 10 patients with venous leakage the flow necessary to create an erection ranged from 160 to 250 ml/min; after injection of papaverine it decreased to 50 to 120 ml/min and remained higher than in the two former groups. Although cavernography-cavernometry with papaverine injection correlates better with the physiological status of the erectile mechanism it provides no more information than when used alone.

Adult↗