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Biomedical subjects

E Weigl

Publications and source records attributed to E Weigl.

At least 55 records · Page 3Linked to original sources

Conditioned pathogenicity of Microsporum gypseum biochemical mutants.

Experimental infections of guinea pigs with three biochemical mutants of Microsporum gypseum are described. Under normal conditions the mutants are avirulent. The virulence became manifested in two mutants (1) when substance necessary for growth of individual mutants were brought into the place of inoculation, (2) when the defense mechanism of the organism was altered with the application of immunosuppressive drugs. One of the mutants was permanently avirulent. The importance of experimental results for explanation of conditioned pathogenicity of some dermatophytes is discussed.

Adenine↗

Activity changes of chicken enzymes involved in glutamate and 2-oxoglutarate metabolism at the time of hatching.

At the time of hatching, activities of both KDH and succinate thiokinase increased in heart, while in liver only an enhanced activity of KDH was observed. Glutamate injected into egg exerted a stimulatory effect on KDH activity in chicken embryos but not in newborn chickens. There seems to be an age-dependent response of ASAT and GDH to stimulating effectors. In chicken embryos, 2-oxoglutarate induced GDH activity and in newly hatched chickens, ASAT activity. Concomitantly, liver protein content increased also. Administration of glutamate, however, was not followed by a significant activity increase of ASAT or GDH. Thus, the stimulation of ASAT and GDH activities seems to be favoured when they support glutamate formation out of 2-oxoglutarate.

Aging↗

Temperature induced dimorphism in Microsporum gypseum.

The biochemical mutant of Microsporum gypseum requiring adenine shows characteristic dimorphism dependent upon temperature. At 37 degrees C it produces faviform aconidial colonies with spherical swollen cells similar to thin-walled chlamydospores. At 26 degrees C it yields the usual mycelium with conidia. Conversion of the faviform and mycelial forms is controlled by temperature and reversible.

Adenine↗

On the late prognosis of type A virus hepatitis.

5.2% healings by second intention must be added to the 91.4% healings by first intention. The proportion of patients (1.1%) who could not be followed up for various reasons is but small. In view of the findings of this epidemiologically founded study, it seems justified to conclude that the long-term prognosis of acute type A virus hepatitis may be considered to be favourable since healing occurred in 96.6%.

Acute Disease↗

[Future of neuropsychology].

The future development of neuropsychology as an independent discipline, which has as its principal subject the relationships between the brain as a material substrate and the psychic behavior shown by human beings as well as animals, is discussed on the basis of a schematic presentation of the possible structure of this discipline (general, genetic, clinical and pathological, and applied neuropsychology.

Animals↗