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Biomedical subjects

E Watanabe

Publications and source records attributed to E Watanabe.

At least 181 records · Page 10Linked to original sources
PubMed1982

[Use of a lipid lymphographic agent, lipiodol, as a carrier of high molecular weight antitumor agent, smancs, for hepatocellular carcinoma].

Two advantages of the present therapeutic approach were described. Firstly, a selective deposition of lipiodol in tumor tissue was verified, thus more precise and accurate diagnosis by X-rays was possible either by CT or plain X-ray film. Secondly, pronounced accumulation of smancs in tumor tissue was observed, which established highly effective chemotherapy of unresectable hepatoma of 22 cases and 12 other cases based on (a) decrease in alpha-fetoprotein (86%), (b) tumor size (95%) and histology. Drug was given via the hepatic artery mostly 3-4 mg in 3-4 ml of lipiodol once every 3 to 4 weeks. Most patients have experienced a total dose of 6-8 mg in two cycles, but drug activity lasted more than 3 weeks. Neither hematosuppression nor anaphylaxis was observed. Major side effect was transient fever (38-39 degrees C) in about 50% of the cases which lasted no more than one week. Other minor side effect was abdominal pain during or after arterial infusion which lasted for about 20 min. Liver function was affected very slightly if any. Mild leukocytosis was observed in 65% of the patients.

Adult↗
PubMed1982

[FT-207 maintenance therapy of malignant gynecologic cancer].

Maintenance treatment with FT-207 was applied to 92 patients with uterine cancers after initial treatments were performed. Daily dosage of FT-207 was either 600 or 800 mg and the drug was administered orally. The duration of 6 months and the total dosage of 100 g were proposed as administration schedule and 34 patients (37%) received this regimen. Side effects during the treatment were observed in 35 cases (38%). Gastrointestinal disturbance was most frequently observed and other side effects included myelosuppression, general fatigue, hepatic dysfunction and skin toxicities. There were no serious side effects, the treatment was continued in most patients and was interrupted only in 7 cases (8%). In the cases of recurrence or advanced cancer, however, the side effect was the predominant cause for interruption of administration. As for the antitumor effect of the treatment, a survival rate of the patients with cervical cancer of early stages was evaluated. Three-year survival rate in the treatment group was higher comparing to the one reported hitherto.

Antineoplastic Agents↗
PubMed1981

Demonstration of zonal projections from the cerebellar flocculus to vestibular nuclei in monkeys (Macaca fuscata).

Purkinje cells in the flocculus of macaque monkeys were labeled by retrograde axonal transport of horseradish peroxidase from the vestibular nuclei. These neurons are organized in three adjacent, narrow bands which span all folia of the ipsilateral flocculus. The central band, 500-750 micrometer wide, projects to the medial vestibular nucleus, while the two adjacent bands, each 300-500 micrometer wide, innervate the superior vestibular nucleus. These three bands cover about one-half of the total area of the Purkinje cell layer of flocculus. Thus, the pattern of zonal projections in monkeys is the same as reported in rabbits and cats.

Animals↗
PubMed1981

Evidence of a collateralized climbing fiber projection from the inferior olive to the flocculus and vestibular nuclei in rabbits.

In albino rabbits, horseradish peroxidase injections confined to vestibular nuclei retrogradely labeled neurons in the dorsal cap of the contralateral inferior olive. Mapping with stimulating electrodes revealed that stimulation of the lateral aspect of the medial vestibular nucleus and the medial aspect of the inferior vestibular nucleus evoked field potentials representing antidromic activation of contralateral dorsal cap neurons. These responses interfered with the antidromic response evoked from the contralateral flocculus and orthodromic responses evoked from the contralateral retina, suggesting that dorsal cap neurons which both receive retinal input and project to the flocculus send collaterals to vestibular nuclei.

Animals↗
PubMed1981

The distribution of plasma norepinephrine concentration and the relation of plasma norepinephrine concentration to pulmonary arterial pressure in heart disease.

Plasma norepinephrine (NE) concentration was measured in blood samples from the pulmonary artery (PA), the superior vena cava (SVC), the inferior vena cava (IVC) and the femoral artery (FA) in 34 patients undergoing diagnostic cardiac catheterization. In patients with pulmonary hypertension, the mean plasma NE concentrations in PA, SVC and FA were significantly higher than that of IVC, but no such difference was found in patients without such hypertension. Except in IVC, the plasma NE concentration in patients with pulmonary hypertension was significantly higher than in others. Furthermore, the plasma NE concentration was positively correlated with the mean pulmonary arterial pressure and inversely related to pulmonary arterial oxygen saturation in patients without a shunt. These results suggest the possibility that vasoconstriction by the sympathetic nervous system may contribute to the development of pulmonary hypertension in patients without the shunt.

Adolescent↗
PubMed1981

Sympathetic nervous systems in chronic cor pulmonale.

Twenty-three patients with chronic respiratory failure and 30 normal subjects were studied to assess the sympathetic nervous activity in chronic hypoxic states, especially in chronic cor pulmonale. Of the 23 patients, 13 had a right ventricular hypertrophy (RVH) pattern on the electrocardiogram. Plasma norepinephrine (NE), dopamine-beta-hydroxylase (DBH), cyclic adenosine 3',5'-monophosphate (cyclic AMP) and cyclic guanosine 3',5'-monophosphate (cyclic GMP) concentrations were measured before and after oxygen inhalation. Plasma NE concentrations were 0.57 +/- 0.07 ng/ml in patients with chronic respiratory failure and 0.22 +/- 0.02 ng/ml in controls (p less than 0.001). Moreover, plasma NE concentrations were higher in patients with RVH than without (p less than 0.05), and these concentrations decreased significantly (p less than 0.05) in the former patients after oxygen inhalation. Plasma cyclic AMP concentrations were 31.2 +/- 2.6 pmol/ml in cases of chronic respiratory failure and 17.4 +/- 0.7 pmol/ml in controls (p less than 0.001) with no difference in plasma cyclic GMP and DBH concentrations. These results suggest that a significant proportion of patients with chronic respiratory failure, especially with cor pulmonale, were in hyper-adrenergic states partially due to hypoxia.

Adult↗
PubMed1981

Plasma level of norepinephrine and cyclic nucleotides following acute myocardial infarction.

The plasma concentrations of norepinephrine (NE), adenosine cyclic 3', 5'-monophosphate (cyclic AMP), and guanosine cyclic 3', 5'-monophosphate (cyclic GMP) were measured serially for 2 weeks after the onset of symptoms in 17 patients with acute myocardial infarction (AMI). The mean concentrations of NE in patients without complications were significantly elevated during the first 2 days following AMI. There was a significant correlation between the maximum concentration of plasma NE and of plasma CK. The mean concentrations of plasma cyclic AMP and cyclic GMP in patients without complications were significantly elevated on the first day and for 8 days respectively following AMI. The concentration of plasma cyclic AMP on admission in patients with complications was significantly higher than that in those without complications. There were significant correlations between the maximum concentration of plasma cyclic AMP and those of plasma CK, GOT, and LDH. Significant but weak correlations between the concentration of plasma NE and those of cyclic AMP and cyclic GMP were found. The results of the present study suggest an enhanced sympathetic nervous system activity at an early stage of AMI, a prolonged enhancement of parasympathetic nervous system activity in the course of AMI, and the potential value of plasma cyclic AMP concentrations as a useful index to estimate the seriousness and size of AMI.

Aged↗
PubMed1981

Sympathetic nervous systems in chronic hypoxic states from pulmonary tuberculosis: a clinical study on plasma norepinephrine and cyclic AMP levels.

To evaluate the sympathetic nervous activity in chronic hypoxic states, the plasma concentrations of norepinephrine (NE), cyclic adenosine 3', 5'-monophosphate (cyclic AMP), cyclic guanosine 3', 5'-monophosphate (cyclic GMP) and dopamine-beta-hydroxylase (DBH) enzyme activity were measured in 32 patients with pulmonary tuberculosis and 30 normal volunteers. Moreover, the peripheral arterial-venous difference of concentration of these substance, arterial blood gas levels and spirometric data were studied in these patients. The results of this study demonstrated that the plasma NE and cyclic AMP concentrations were directly related to the degree of hypoxemia and some of the spirometric parameters in these patients. It is concluded that sympathetic nervous activity was augmented in chronic hypoxic states, especially with chronic respiratory failure.

Adult↗
PubMed1981

A significant role of proximity of HVJ-antigen in the generation of tumor immunity.

According to the blocking test for proximity of cell surface antigens, L1210 leukemia-associated antigen was not linked to molecules carrying H-2d antigen or murine leukemia virus-associated antigen, but there was a close association between HVJ-associated antigen and L1210 leukemia-associated antigen on the surface membrane of HVJ-pi-infected L1210 leukemia cells. Once L1210 leukemia cells were infected with HVJ-pi, their adsorptive power was found to be greater than that of uninfected cells by quantitative absorption analysis. These phenomena may lead to a better recognition by the host of L1210 leukemia-associated antigen, followed by generation of tumor immunity.

Absorption↗