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Biomedical subjects

E Walter

Publications and source records attributed to E Walter.

At least 181 records · Page 10Linked to original sources
PubMed1978

[Contrast extravasation from the pelvicalycine system during infusion pyelography (author's transl)].

Rupture of the pelvicalycine systems is occasionally observed during infusion pyelograms. Twenty such cases are reported. The usual cause was the presence of stones in the ureter leading to urinary tract obstruction and acute pressure rise in the pelvicalycine system. The anatomical and physiological basis for the rupture is outlined. Subsequently our own cases are described. In 13 patients rupture occurred without previous renal abnormality; in these there was always spontaneous healing once the obstruction had been removed. In five patients rupture occurred in a previously damaged kidney; the changes at the point of rupture and the subsequent possible complications are described. Two cases should be mentioned in detail; in these, rupture persisted and lead to the development of a retroperitoneal pseudocyst. Only one similar case is reported in the literature since 1966.

Adult↗
PubMed1978

[Ulnar aplasia (author's transl)].

Aplasia of the ulna is a rare malformation of the forearm. A woman patient with such malformation was presented in our clinic on the occasion of a banal dream. In addition to ulnar aplasia, her entire ulnolateral hand was missing. This findings is compared with the relatively few cases described in literature, reporting on the forms of ulnar aplasia observed so far and their additional local malformation. Assumptions regarding the possible origin of such malformations are mentioned, the combined malformations in other body regions as mentioned in literature are described, and brief reference is made to methods of treatment.

Abnormalities, Multiple↗
PubMed1978

[Familial congenital radio-ulnar synostosis (author's transl)].

Radio-ulnar synostosis is a congenital bony union between radius and ulna, usually in the vicinity of the radial tuberosity. A family is described on whom this anomaly was inherited over three generations. The rare cases described in the literature were usually bilateral, in our family it was unilateral. The following aspects are discussed: the frequency of this condition, the anatomical localisation of the synostosis, their types, local soft tissue and other abnormalities, embrylogy and the hereditory pattern. Finally, methods of treatment are discussed briefly.

Aorta, Thoracic↗
PubMed1978

[Problems and possible errors in monitoring drug side effects at the hospital (author's transl)].

Special problems and possible errors in drug monitoring were discussed by analyzing three cases of hospital treated patients. The first one showed how easily side effects of drug can be falsely diagnosed and treated as a drug independent complicating disease. Furthermore, the active principle of the drug had to be differentiated from several potentially inducing substances. In the second case, the wrong diagnosis of a drug induced illness caused an intermission of a vital basic therapy. The lateron developing signs were interpreted as symptoms of the primary disease but they might also have been caused by drugs given later. For the third case it should be pointed out that side effects can be provoked during long- or short-term treatment by changing the diet. For drug monitoring it is therefore equally necessary to watch the drugs as well as the living circumstances.

Adult↗
PubMed1978

[Effect of halofenate on triglyceride and uric acid levels, coagulation and platelet behaviour in patients with hyperlipoproteinemia type IV and hyperuricemia (author's transl)].

From experimental work, an influence of a drug with hypolipidemic and hypouricemic acition on blood coagulability and platelet function may be expected. Consequently, if these effects were demonstrable in man the drug could be assumed to reduce the tendency to develop thrombosis and atherosclerosis in patients with hyperlipidemia and hyperuricemia. In the study reported, the effect of 2-acetamidoethyl-(p-chlorophenyl)-(m-trifluoro-methylphenoxy)-acetate (halofenate) was investigated in 14 patients suffering from hyperlipoproteinemia type IV and hyperuricemia. Platelet aggregation and adhesiveness, plasma levels of triglycerides, cholesterol, uric acid, and clotting factors were regularly examined during a three-month double blind trial. While uric acid and triglyceride levels decreased, no influence of the drug treatment could be observed on platelet function and blood coagulability by the laboratory methods used.

Adult↗
PubMed1978

[Effect of sulfinpyrazone on enhanced platelet aggregation in vitro (author's transl)].

Adding sulfinpyrazone in a concentration of 500 and 250 microgram/ml to blood of patients with enhanced platelet stickiness a significant decrease (p less than 0.01) of the maximum amplitude and the aggregation velocity could be demonstrated with the spontaneous platelet aggregation test, PAT III, of Breddin, as well as with the collagen and the ristocetin induced aggregation. The lower concentration of 50 microgram/ml of sulfinpyrazone yielded the same results when aggregation was induced with the higher concentrations of 1.5 microgram/ml ristocetin and 5 microgram/ml collagen. Only the maximum aggregation velocity of the PAT III was significantly reduced after addition of 50 microgram sulfinpyrazone/ml blood. With sufficient concentrations of sulfinpyrazone the anti-aggregating action of this substance can very well be demonstrated with the aggregation induced by ristocetin or collagen and the PAT III. The effect is dose dependent.

Aged↗
PubMed1977

[Oral anticoagulants and platelet function in hypolipemic therapy using a new clofibrate analog (BM 15.075) (author's transl)].

When testing the effect of a new clofibrate analogue (BM 15.075) on oral anticoagulation and blood clotting in 15 patients for over four weeks it was demonstrated that, depending on the dose of the drug, there was an increase in anticoagulation. The dose of phenprocoumon had to be reduced by 20.6 or 28.7%, respectively, when BM 15.075 was given at a dose of 450 or 600 mg. There was an inhibition of collagen-induced platelet-aggregation. In parallel there was an increase in bleeding time. Fibrinogen concentration was slightly but statistically not significantly decreased. Euglobulin lysis was shortened, especially if previously abnormally long. There was no direct influence on other plasmatic clotting factors.

Aged↗
PubMed1976

Penicillin-induced coagulation disorder.

A coagulation disorder was seen after penicillin-G administration (10 million units/day) in uraemic patients and after high-dose penicillin G (40 million units/day) in patients with a normal glomerular filtration-rate (5 patients after cardiac surgery). This disorder was characterised by: prolongation of bleeding-time, appearing immediately after penicillin-G administration and persisting until 4 days after withdrawal of therapy; disturbance of collagen-induced and ristocetin-induced platelet aggregation; increase of antithrombin-III activity; and inhibition of factor-xa activity. The inhibition of factor-xa activity corresponded to that seen after low-dose-heparin prophylaxis. The clinically latent coagulation disorder, when super-imposed upon pre-existing coagulation abnormalities (uraemia, treatment with anti-coagulants) may cause severe bleeding, as observed in 1 patient with acute renal failure on haemodialysis.

Abscess↗
PubMed1975

[The effect of acetylsalicylic acid, extremely restricted movement and a cholesterol-rich diet on atheromatosis of the rabbit aorta: comparative investigations (author's transl)].

A multifactorial model for demonstrating the pathogenesis of the diet-induced atheromatosis of the rabbit is described. We examined the effect of various diets (atherogenetic, rich in fibre, mixed, normal) and of extreme restriction of movement, with and without doses of acetylsalicylic acid. The aorta showed uniforms morphological findings; 1. Acetylsalicilic acid no influence on the cholesterol-induced atheromatosis of the rabbit; 2. An atherogenic diet and a diet rich in raw fibre caused different degrees of sclerosis of the aorta; this was related to the cholesterol content of the mixed diet, which was 50% less than the cholesterol content of the atherogenic diet; 3. Macro- and microscopic examination showed that extreme restriction of movement alone has no demonstrable effect on the aorta of the rabbit; 4. The cholesterol-induced atheromatosis showed significantly less involvement of the aorta when there was extreme restriction of movement in addition to the diet; 5. In none of the test groups could we demonstrate any effect of PAT I on platelet adhesiveness; 6. The test conditions did not result in an activation of the contact phase of the haemocoagulation system.

Animals↗