[On three cases of rare big tumor on palate benign mixed tumor, malignant mixed tumor, and lymphosarcoma].
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Diagnosis, Differential↗
Biomedical subjects
E Takeuchi
Publications and source records attributed to E Takeuchi.
The interaction of Hg++ with deoxyribonucleic acid.
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Animals↗
Cellular, biochemical and molecular characterization of the bovine temporomandibular joint disc.
The cellular and collagenous components of the bovine temporomandibular joint (TMJ) disc have been isolated and analysed. In the central regions of the disc, significant amounts of type I, II, IX and XII collagen were found. The identity of these molecules was verified with collagenase digestions, Western blot analysis and Northern blot analysis (for type II collagen). Cells isolated from the TMJ disc synthesized alkaline phosphatase, proteoglycans and collagen in culture; however, the basal rate of synthesis for these molecules was lower than that for isolated osteoblasts, articular and growthplate chondrocytes. The TMJ disc cells proliferated more rapidly in culture than osteoblasts or chondrocytes. Transforming growth factor-beta stimulated proliferation by 250%, whereas prostaglandin E2 had no effect.
Alkaline Phosphatase↗
Multiple symmetrical lipomatosis: no longer just a Mediterranean disease?
Multiple symmetrical lipomatosis is a rare condition, of which the etiology remains unclear. Most reported cases have been from the Mediterranean countries, and it is generally thought of as a disorder characteristic of that region. However, there have been 11 cases reported in Japan since 1978, suggesting that this condition is no longer confined to Mediterranean countries.
Adult↗
Aspiration biopsy cytology of secretory carcinoma of the breast. A case report.
Secretory carcinoma diagnosed by aspiration biopsy cytology (ABC) disclosed many characteristic figures that were similar to a bunch of grapes, secondary mucous globular structures (MGSs) and clustered MGSs. The MGS was a unit structure of secretory carcinoma composed of a centrally located, small amount of mucus and two or more tumor cells covering it. Other findings were vacuolated cells and mucus in a clear background. The presence of the above findings, especially the "bunch of grapes" and related forms, were though to be essential findings in the cytologic differential diagnosis of secretory carcinoma by the ABC method. The origin of the characteristic features is discussed.
Adult↗
Fine needle aspiration cytology of lipid-secreting carcinoma of the breast. A case report.
Fine needle aspiration (FNA) cytology of lipid-secreting carcinoma of the breast was performed on a 43-year-old woman who was admitted with a left breast tumor. Smears of the aspirate showed atypical cells that contained numerous large and small vacuoles in the cytoplasm and were diagnosed as adenocarcinoma of the breast. A modified radical mastectomy was performed under the diagnosis of breast carcinoma. A solid, yellowish, milky white, well-demarcated tumor was found in the resected specimen. Microscopically, hematoxylin and eosin staining revealed foamy and granular vacuoles in the cytoplasm of the tumor cells similar to those seen on the smears, which were positive for lipid staining. Electron microscopic examination also showed numerous intracytoplasmic lipid droplets in the tumor cells. This tumor was finally diagnosed as lipid-secreting carcinoma of the breast on the basis of histologic and electron microscopic features. Lipid-secreting carcinoma of the breast is rare, and only one recurrent case diagnosed by cytology in pleural and pericardial fluids has been described. Since the tumor cells originating in lipid-secreting carcinoma of the breast differ from ordinary breast carcinoma cells, FNA cytology is useful in diagnosing this neoplasm.
Adult↗
A case of pleomorphic adenoma of the lung with multiple distant metastases--observations on its oncogene and tumor suppressor gene expression.
Pleomorphic adenoma of the lung is a rare neoplasm. Here we describe the first report on oncogenes and tumor suppressor genes in metastasizing pleomorphic adenoma of the lung. A 48-year-old Japanese woman presented with metastasizing pleomorphic adenoma in which both the primary lung tumor and metastatic lesions were composed of benign pleomorphic structures. The mechanism of the metastatic potential was examined by analyzing known oncogenes and tumor suppressor genes by DNA blot analysis and immunohistochemistry. No rearrangements amplifications or overexpressions of oncogenes, bcl-2, c-erbB-2, c-myc, L-myc, N-myc, Ha-ras and Ki-ras were found. In addition, immunohistochemical studies showed no aberrance in expressions of the tumor suppressor gene products, RB, p16 and p53 in the tumor. Some unknown mechanism(s) seems to be responsible for the aggressiveness of this metastasizing pleomorphic adenoma. This mechanism must be elucidated by studies on further case of this rare tumor.
Adenoma, Pleomorphic↗
Successful treatment of metastatic cardiac lymphoma with complete A-V block.
Although involvement of the heart is not a rare manifestation of malignant lymphoma, most cases are diagnosed by postmortem examination. In the present article, we describe a man with metastatic cardiac lymphoma with complete A-V block successfully treated by resection of the heart tumor and sequential combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and predonisolone and radiation therapy. Combination modality resulted in complete disappearance of signs of heart failure and A-V block. Our experience indicated that early diagnosis and combination modality can obtain long survival in case of metastatic cardiac lymphoma.
Aged↗
A case with small cell carcinoma of the esophagus: measurement of tumor markers, including pro-gastrin-releasing peptide.
Small cell carcinoma of the esophagus is a rare clinical entity and the accumulation of information is necessary to clarify its clinical behavior. We report a 69-year-old Japanese man with this rare disease with systemic metastases, including liver, bone and lymphnodes. The patient was treated with systemic chemotherapy consisting of 300 mg/m2 of carboplatin on day 1, and 80 mg/m2 of etoposide on days 1, 2 and 3. Although transient relief of subjective symptoms was obtained, the disease showed systemic progress, and the patient died on day 25 of chemotherapy. During the clinical course of the disease, serum pro-gastrin-releasing peptide (proGRP) decreased upon systemic chemotherapy from elevated level (54.6 pg/ml) to normal range (19.2 pg/ml). Further study is warranted to examine whether measurement of serum proGRP may yield valuable information on the diagnosis and monitoring activities of esophageal small cell carcinoma.
Aged↗