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Biomedical subjects

E Svejgaard

Publications and source records attributed to E Svejgaard.

At least 37 records · Page 2Linked to original sources
PubMed1985

Oral ketoconazole as an alternative to griseofulvin in recalcitrant dermatophyte infections and onychomycosis.

In an open study 58 patients with chronic dermatophytosis mainly caused by Trichophyton rubrum and five patients with Tinea capitis were treated with ketoconazole. The indications were ineffectiveness of or side effects to griseofulvin. Response to treatment varied from 1 week in scalp infections to 11 weeks in toe-nail lesions. Dermatophytosis of hands and feet were cured in 25%, marked improvement observed in further 30%. Toe- and finger-nail infections were cured in 20% and 43%, respectively, and marked improvement seen in further 36% and 14%, respectively. All scalp infections were cured without relapse. Recurrence of infections before 6 months after treatment was seen in 55-60% of hand and foot lesions and 33-38% of finger and toe-nail infections. In a double-blind study 20 patients with onychomycosis caused by T. rubrum the efficacy of ketoconazole was compared to that of griseofulvin. Cure rates in the griseofulvin group were 25% for finger-nails and zero for toe-nails, while 50% and 57% experienced marked improvement. In the ketoconazole group, 25% of finger-nail infections were cured and 75% markedly improved, while the corresponding figures for toe-nails were 11% and 89%, respectively. Adverse reactions to ketoconazole were seen in 29 (46%) of the patients in the open study and in 2 (20%) in the double-blind study and comprised mainly minor complaints. Side effects caused discontinuation in 12 patients, in two of whom due to toxic hepatitis.

Administration, Oral↗
PubMed1985

Trichophyton rubrum specific IgE in serum in patients with chronic T. rubrum infection as demonstrated by crossed radio-immuno-electrophoresis.

By means of crossed radio-immunoelectrophoresis specific IgE antibodies to Trichophyton rubrum were demonstrated in serum from seven of eight patients with chronic T. rubrum infection. Total IgE values were within normal limits in all. In contrast, no specific IgE antibodies were found in sera from 10 patients with inflammatory ringworm lesions due to Microsporum canis, T. mentagrophytes or T. verrucosum or from six non infected controls. A long-lasting exposure to a constant antigen load is considered of importance for the development of humoral immunity including IgE production.

Antibodies, Fungal↗
PubMed1984

Clinical and immunological studies in chronic dermatophytosis caused by Trichophyton rubrum.

Twenty-six patients with chronic dermatophytosis (CD) by Trichophyton rubrum (TR) through one year were included in a double-blind clinical trial with Levamisole/Placebo. All patients were treated with griseofulvin concomitantly. Before, during and after the trial, studies of the cellular and humoral immune response were performed. The result of treatment with griseofulvin plus levamisole (62.5% cured or improved) did not differ from that of griseofulvin plus placebo (58% improved). All patients but one showed normal general cellular immune responses. Stimulation of lymphocytes with a specific TR antigen extract showed a significantly stronger response in the patient group than in the group of 39 controls (p = 0.01-0.00003) at all investigation dates. Immediate weal reactions to the TR extract were seen in 42% of the patients and increased concentration of IgE antibodies was demonstrated in 46%. Specific IgG antibodies towards TR were observed in 42% of the patients. The presence of specific IgG antibodies and a strong specific cellular immune response were related to the severity of clinical involvement. Environmental factors and atopy were associated disorders in 81% and 77% respectively.

Adult↗
PubMed1984

Antigen-free diet in adult patients with atopic dermatitis. A double-blind controlled study.

The efficacy of an antigen-free diet on the activity of atopic dermatitis was examined in a double-blind study, comprising 33 adults with severe atopic dermatitis. The antigen-free diet (Vivasorb) was compared to a placebo diet during three weeks of hospitalization. Twenty-five patients were evaluable, two of whom had their diet stopped after a few days due to exacerbation. Nine patients improved, while 16 patients were unchanged. Among those who improved five patients had Vivasorb and four placebo diet. In the remaining group 11 patients had Vivasorb and five had placebo. Four patients reported of less pruritus, sleeplessness and antihistamine consumption (three Vivasorb, one placebo) while 21 did not (13 Vivasorb, eight placebo). Thus, there were no significant differences between the groups. Paraclinical studies of circulating eosinophilocytes, serum IgE, orosomucoid, HLA-antigens, and immunofluorescence of skin biopsies showed no differences between the Vivasorb and the placebo groups. The results from the examination of this relatively small number of patients suggest that elementary intolerance plays little role in the etiology of atopic dermatitis in adults.

Adolescent↗
PubMed1983

HLA studies in chronic dermatophytosis caused by Trichophyton rubrum.

The HLA-ABC antigens were investigated in 34 and DR antigens in 28 patients with chronic dermatophytosis caused by Trichophyton rubrum. The distribution of the antigens did not differ from that of the controls. Abnormal immune response may be of importance in the susceptibility to chronic dermatophytosis, but HLA-controlled immune mechanisms seem unlikely.

Chronic Disease↗
PubMed1982

Acantholysis induced by proteolytic enzymes. II. Enzyme fractions produced by Trichophyton mentagrophytes.

Trichophyton mentagrophytes produces three enzyme fractions of molecular weight 65,000, 92,000 and 18,000, respectively. Normal human skin was cultivated and the specimens were subjected to electron microscopy. Enzyme fraction I showed the capacity to induce epidermal acantholysis and dermo-epidermal separation, while the other two fractions showed no proteolytic nor keratinolytic action in cultivated skin.

Acantholysis↗
PubMed1982

Lymphocyte transformation in vitro in acute dermatophytosis: a follow-up study.

Sixteen patients with recently acquired (= nonchronic) dermatophytosis were studied clinically and immunologically before, during and after treatment for 6 months. The methods applied were lymphocyte transformation in vitro (LTT) and intra-dermal test (IDT). Phytohaemagglutinin, pokeweed mitogen, purified protein derivate (PPD) and water-soluble extracts of Trichophyton (T) rubrum, T. mentagrophytes and Candida albicans were used as stimulators. In the LTT the patients in all four studies showed normal general immune responses. Compared with a control group of 22 healthy persons, lymphocytes of the patients showed significantly stronger stimulation with the T. rubrum extract (0.01 greater than p greater than 0.001) throughout the 6 months. The degree of stimulation after one month (the second study) was significantly stronger (0.05 greater than p greater than 0.01) than in the other studies. The stimulation in the last (fourth) study was the lowest (not significant). IDT showed a majority of delayed-type reactions (47-67%) in patients as compared with 7-13% in the controls, when using dermatophyte antigens. Three patients had an immediate-type reaction or mixed reactions. A correlation was found between the severity of lesions and the degree of stimulation in LTT (p less than 0.02 for T. rubrum, p less than 0.007 for T. mentagrophytes). In contrast, no relationship was found between IDT and clinical symptoms, and there was only a slight tendency toward correspondence between the results of IDT and LTT.

Acute Disease↗
PubMed1981

In vitro nickel binding to mononuclear cells in peripheral blood.

Mononuclear cells from the peripheral blood of four nickel-sensitive persons and 4 controls bound equal amounts of 63 nickel in vitro. 90--99% (mean 96%) of the 63 nickel was removed from the cells by washing three times every 30 minutes for 120 minutes. For 4 other patients and 4 controls, lymphocyte transformation with autologous nickel-incubated, irradiated cells as the stimulant showed that nickel was bound to the cells in sufficient quantities and was present in a form which could induce lymphocyte transformation in vitro in nickel-sensitive patients.

Dermatitis, Contact↗
PubMed1980

Multiple kerato-acanthoma: a case report.

A case of multiple keratoacanthomas in a 36-year-old healthy seaman is presented. Four months prior to the onset of the disease the patient had been exposed to strong sunlight. Histopathological examination gave the diagnosis of keratoacanthoma.

Humans↗
PubMed1979

Antibodies against nickel-albumin in rabbits and man.

Five albino rabbits were immunized every 2 weeks by intradermal injections of a nickel rabbit-albumin complex and during alternate weeks by occluded cutaneous applications of 5% nickel sulphate in petrolatum. After 6 weeks of immunization, passive immunodiffusion disclosed precipitating antibodies against the nickel-albumin complex in the serum of the rabbits. The specificity of these antibodies was substantiated by the precipitation of anti-albumin antibodies with rabbit albumin prior to immunodiffusion. Passive immunodiffusion was used to examine serum from 14 nickel-sensitive patients for precipitating antibodies against nickel human-albumin complex. Five of the patients had widespread erythematous, non-eczematous reactions following oral challenge with 2.5 mg nickel as nickel sulphate, while five others suffered an aggravation of their nickel dermatitis. Precipitating antibodies were found in three patients, all of whom had experienced rapid-onset erythema after oral challenge. A weak precipitate was seen in one of nine controls. The specificity of the precipitates was substantiated by reproducibility and by negative immunodiffusion after precipitation in the positive sera with the antigen.

Albumins↗
PubMed1979

Precipitating antibodies in dermatophytosis demonstrated by crossed immunoelectrophoresis.

A total of 289 serum specimens from 262 patients with dermatophytosis were studied, using crossed immunoelectrophoresis with an intermediate gel. Rabbit antidermatophyte antisera were used as reference, and the antigens were water soluble extracts of Trichophyton (T) rubrum, T. mentagrophytes, Microsporum (M.) canis or Epidermophyton (E.) floccosum. Each serum was tested against the dermatophyte antigen corresponding to the infectious agent of the patient in question. Antidermatophyte antibodies could be demonstrated in 25 (9.5%) of the patients, and these were particularly frequent in patients with highly inflammatory lesions and those with chronic dermatophytosis caused by T. rubrum. Antibodies were detected in all four patients with kerion Celsi. Nine patients, five with acute dermatophytosis and four with chronic disease, who had precipitating antibodies at the initial examination were studied several times during the course of the disease. While the antibodies disappeared in all the patients with acute disease, they persisted in those with chronic dermatophytosis. The human antibodies showed marked cross reactivity with T. rubrum, T. mentagrophytes, M. canis and E. floccosum.

Antibodies, Fungal↗
PubMed1979

In vitro lymphocyte transformation to nickel: a study of nickel-sensitive patients before and after epicutaneous and oral challenge with nickel.

An in vitro lymphocyte transformation test (LTT) was performed in 8 patients with nickel contact dermatitis and in 4 control persons. The mitogenic response was of the same magnitude before patch testing, after patch testing and after oral challenge with nickel. When purified protein derivative (PPD) was used as the antigen, there was no difference between the LTT response of patients and controls before and after patch testing. After oral challenge with nickel, however, the patients' responses to PPD were significantly increased when compared with the responses after patch testing. The responses of the controls were unchanged. The LTT levels of the patients were approximately the same before and after patch testing, but were markedly increased after oral challenge.

Administration, Oral↗