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Biomedical subjects

E Straube

Publications and source records attributed to E Straube.

106 records · Page 6Linked to original sources

Do schizophrenics use linguistic rules in speech recall?

Varying degrees of organization of verbal material were presented to determine their use in sentence reproduction by acute and chronic schizophrenic subjects, a psychiatric (alcoholic) control group, and a healthy control group. The material consisted of six-word sentences presented over earphones, with background noise of differing intensity. The main result was that schizophrenics use verbal organization as effectively as healthy and psychiatric controls when reproducing the sentences. The noise distraction influenced performance of all groups similarly. Results suggest that performance of schizophrenics is facilitated by structured material (semantic and syntactic organization). The results do not suggest that either the linguistic repertoire or the application of linguistic rules is specifically affected in schizophrenia. The flatter performance slope of schizophrenics with increasing contexual constraints, found by some researchers, is explained by the unspecific effect of task difficulty.

Acute Disease↗

[Serodiagnosis of a chronic pyelonephritis using common antigen].

By means of the indirect haemagglutination reaction we examined for antibodies against the enterobacterial common antigen 113 sera of blood-donors and 588 sera of patients with chronic pyelonephritis. It could be shown that this antigen is not suitable for the proof of antibodies and thus for the serodiagnostics of a chronic pyelonephritis. Also the combination with the results of the antibody determination against the O-antigen of the homologous strain of the urine is without diagnostic relevance.

Antibodies↗

[Studies on psychophysiology in Schizophrenia (author's transl)].

The psychophysiological and psychopathological implications are discussed for the finding that absence of electrodermal orienting response to acoustic stimuli was observed among 40% of the schizophrenic patients in two samples. It was found that withdrawal symptomatology and thought disturbance frequently appear among those patients without orienting response. Examples from previous studies are presented which verify deficient or excessive responses of schizophrenics in other physiological variables. It is suggested that extreme psychobiological primary characteristics of schizophrencis be taken into account in psychopharmacological therapy.

Chronic Disease↗

[Bacteriological studies of the human amniotic fluid in repeated amniocenteses].

The amniocentesis to gain increasing importance ought to be examined whether an alteration of the bacterial flora of the amniotic fluid was caused by repeated amniocentesis. 128 samples of amniotic fluid selected by abdominal amniocentesis were placed in microbiological cultures. Bacteria was isolated in 30 cases, originated predominantly by pollution. Under the circumstance of strong sterile conditions the amniocentesis proven even when repeated a diagnostical way of procedure which does not represent any danger to mother nor child.

Amniocentesis↗

[Microbiological diagnosis of pyelonephritis].

Microbiological methods occupy an important place in the diagnosis of pyelonephritis. Taking into consideration still open problems, the principles of the bacteriological and serological diagnosis of infections of the urinary tract are discussed.

Bacterial Infections↗

[Speech behavior of schizophrenics. Assay of an experimental point of departure (author's transl)].

Schizophrenic subjects and a control group of healthy subjects were tested with the following three language tasks: (1) to complete interruptions in a text, (2) to compose sentences from a sample of words written on cards and (3) to associate word cards to certain concepts. Besides the correct words, so-called irrelevant words were given as distracting stimuli. The inferior performance of the acute paranoid hallucinating subjects is interpreted in the sense of disturbance of cognitive selective functions. It is assumed that the central nervous inhibition of irrelevant stimuli fails to work successfully in certain groups of schizophrenics.

Female↗

[Experiments on perception in schizophrenia (author's transl)].

Acute and chronic schizophrenic subjects were tested with 6 simple experimental tasks of visual stimulus selection. The 2 control groups were a group of non-psychiatric subjects and one of patients with other psychiatric diagnoses. The 6 experimental tasks represented three different types of attention: 1) differentiation between "figure" and "background", 2) concentration; 3) visual integration (Gestalt completion). The main result was that the acute group with paranoidal psychosis and hallucinations made significantly more mistakes in figure-background differentiation (grouping of patterns). But there was no difference between this group and the other patients in the concentration tasks. Both schizophrenic groups performed more poorly in the Gestalt completion task. The results are discussed in light of the information theory (breakdown of a hypothetical filter mechanism) and Sokolow's psychophysiological model of stimulus selection. The hypothesis is put forward that in the acute schizophrenic group a disturbance in an arousal-modulation system is responsible for attenuation of irrelevant input.

Acute Disease↗

An analysis of the skin conductance orienting response in samples of American, British, and German schizophrenics.

The existing literature dealing with the phasic orienting response (OR) in schizophrenia, examining, for the most part, the skin conductance component (SCOR), reports conflicting results with divergent implications for the nature of the attentional dysfunction in these patients. The present authors have contributed to that literature and to its divergencies. The present report addresses this issue by applying a common set of response definitions and uniform statistical-analytic procedures to the previously gathered electrodermal data obtained independently in each author's laboratory. A total of 14 studies is involved, drawn from six laboratories in the U.S.A., the U.K., and West Germany. Collectively, these studies examine chronic and acute schizophrenics, males and females, those receiving neuroleptic drugs and those not receiving them, recording SCOR from either (or both) hands using a variety of instruments and somewhat differing instructions and conditions, to both auditory and visual stimuli of different intensities and rise-time properties. The authors' purpose is two-fold. First, to determine whether some 'universal' dysfunction can be demonstrated across laboratories, conditions, and samples. Given the heterogeneous origins of these data such a finding would offer fairly strong evidence of 'real' dysfunction in schizophrenia. Second, where disagreement exists, to describe the scope and nature of the disagreement, and to articulate more clearly the findings on each side of a disputed area. One such 'universal' dysfunction emerged. Consistently, schizophrenics displayed an abnormally high incidence of nonresponsiveness, involving nearly 50% of the schizophrenic sample on average. The next most common finding is that many of the schizophrenics who display an SCOR often habituate faster than do nonschizophrenic responders. This was seen in a majority of the studies and laboratories, but conflicting evidence was presented by a minority. Evidence for a dysfunction simultaneously involving SCOR hypo- and hyper-responsiveness within schizophrenia was obtained, but in a minority of studies. The possible effects of neuroleptic drugs, stimulus intensity and rise-time factors, and differential significance evaluation on these findings was discussed. The possibility that schizophrenic dysfunction involves the input-facilitating OR but not input-attenuating 'protective' responses is examined. The correlates of hyporesponsiveness in schizophrenia, including physiological response patterns, clinical symptom patterns, and specific input deficiencies, is also examined. Several areas are noted where systematic research has only begun, and further study is particularly needed.

Adolescent↗