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Biomedical subjects

E Slater

Publications and source records attributed to E Slater.

8 recordsLinked to original sources
PubMed1978

Malignant pleural effusions.

Recurrent malignant pleural effusion is a relatively common problem that often occurs many months before the terminal stages of a patient's malignant disease. Despite careful evaluation, it is often impossible to identify the exact physiologic cause of an effusion and difficult to identify a pragmatic course of therapy. Aggressive management including chest tube drainage, with or without instillation of inflammation-inducing drugs, and radiotherapy or surgery in selected cases is indicated for palliative treatment and probably for increased survival. In formulating a treatment plan, attention should be given to a variety of factors including pathogenic forces in the formation of malignant pleural effusion, tissue type of the metastatic malignancy, general clinical status of the patient, the presence of pleural loculations and adhesions, and the exclusion of other non-malignant causes of pleural effusion.

Antineoplastic Agents↗
PubMed1978

A score for prescribing digoxin.

A simple method of selecting a maintenance dose of digoxin, suitable for an adult patient, was derived from data on 129 patients taking digoxin. Eight items of readily available information are required for entry into the prescribing aid: out/inpatient status, sex, age (less/not less than 70 years), weight (allocated to one of four ranges), whether or not chronically house/chair bound, cardiac rhythm (sinus/other), serum creatinine concentration (allocated to one of four ranges), and diuretic therapy (prescribed/not prescribed). The recommended dose is given in terms of size and number of tablets to be prescribed. Using this method 72.3 per cent of patients are expected to achieve mean steady state serum digoxin concentrations within the therapeutic range, 6.5 per cent above and 21.2 per cent below. This performance would be considerably better than that expected from the use of other prescribing aids. If available, routine measurement of the serum digoxin concentration during follow-up is recommended to detect those who might benefit from a change, usually an increase, in dose.

Aged↗
PubMed1977

Meningococcus.

Explore the source record for details and available documents.

Carrier State↗
PubMed1976

Assisted suicide: some ethical considerations.

When we die, it is only very rarely that we do so without days, weeks, or months of illness in which the suffering may be very great, sometimes from pain, often from breathlessness, impairment of consciousness, depression, anxiety, vomiting, bedsores, and incontinence. If we were able to choose our own time to die, there would be no need to suffer any of this. There should be a "right to die". It should be ethically and legally possible for the doctor attending a terminally ill patient, who asks him for help to take his own life, to put the means within his reach.

Aged↗
PubMed1976

Comparative studies on parenteral and intranasal inoculation of an attenuated feline herpes virus.

Using a temperature sensitive mutant of feline herpes virus, comparative studies were carried out regarding efficacy of the intramuscular and the intranasal routes of administration of virus in inducing resistance to feline rhinotracheitis disease. Susceptible adult animals and kittens with and without parental immunity were used. Resistance to disease was measured by serological and challenge methods. Results in terms of rapidity or induced resistance or immunity as well as the degree and duration of immunity are discussed.

Administration, Intranasal↗