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Biomedical subjects

E Schuller

Publications and source records attributed to E Schuller.

At least 109 records · Page 6Linked to original sources
PubMed1981

[Local and general immunity in diseases of the nervous system].

In normal condition, the nervous system has no local immunity, and general immunity is here very poor. However, in many neuro-immunological diseases, a local immunity appears, i.e.: a local synthesis of immunoglobulins. General immunity may be increased by transudation of blood components into CSF, either separately (inflammatory transudate) or simultaneously (meningitis) with this local synthesis. A mathematical formula is proposed is useful for some reasons: 1) evaluation of local immunity; 2) definition of CSF immunological patterns into 5 types and a neuro-immunological classification of neurological diseases; 3) research of the etiology in some nervous disease; 4) objective analysis of results of immunotherapy. Multiple sclerosis gives a good example of this 4 points of interest.

Capillaries↗
PubMed1981

[Gougerot-Sjögren's syndrome in two univitelline twin sisters (author's transl)].

Two univitelline twin sisters developed Gougerot-Sjögren's syndrome at 30 years of age. Immunity disorders were more significant in the sister with the more severe disorder, as demonstrated by sialography and scintigraphy. Among the immunological tests practiced, emphasis is placed on antinuclear antibody assay in the saliva, the authors finding no mention of this test in the published literature. Of particular interest is the negative result of histological examination of the accessory salivary glands, this contrasting with the close relationship between immunity and sialographic disturbances. The identical nature of the two sisters was confirmed by a study of the HLA systems, but this did not demonstrate the presence of the B8 marker, classically correlated with Gougerot-Sjögren's syndrome.

Adult↗
PubMed1979

IgM and IgG antibody responses in rabies encephalitis.

Immunological survey of 3 patients with proved rabies encephalitis shows three interesting facts. 1) An IgM local synthesis, sometimes proportionally higher than IgG local synthesis, is observed in 8 CSF (among 13 investigated) and detected early, during the first week of the disease for 2 patients. 2) A relative poor IgG response is noted; this response is absent in one and decreasing in the 2 others patients despite their progressive aggravation. 3) A very little elevation of blood nucleic antibodies is detected in 5 CSF only. This very poor synthesis of antinucleic IgG contrast with their common increase in viral encephalitis. Thus, a viral immunosuppression may be discussed in rabies encephalitis, which may contribute to the lethal prognosis.

Encephalitis↗
PubMed1978

DNA and RNA antibodies in serum and CSF of multiple sclerosis and subacute sclerosing panencephalitis patients.

DNA and RNA (nucleic) antibodies were found in the CSF of 18 patients with multiple sclerosis (MS) (out of 45), 11 with subacute sclerosing panencephalitis (SSPE) (out of 12) and 9 controls (out of 30). Viral (measles and rubella, by HAI) antibodies were present in all SSPE, 23 MS and 11 control patients. A clear correlation exists between (1) CSF immunological patterns, (2) oligoclonal aspect, (3) simultaneous presence of nucleic and viral antibodies, suggesting the local synthesis of both. This is confirmed by the comparison of the ratios IgG/antibodies in serum and CSF: the CSF ratio may be higher for nucleic and/or viral antibodies in SSPE and MS patients. Thus nucleic antibodies seem to be related to a persistent active infection within the central nervous system.

Antibodies↗
PubMed1978

Serum and cerebrospinal fluid IGM in 203 neurological patients.

Simultaneous serum and CSF IgM determinations were made by electroimmunodiffusion in 5 normals and 203 patients. Absent from normal CSF, IgM was found in 56 patients (27%): (1) A blood-CSF transudation was present in 25 patients (12%). IgM seems of no diagnostic value in these cases. (2) A purely local synthesis was demonstrated in 17 patients (8%), concerning proved (bacterial, viral, parasitic) or supposed (multiple sclerosis) persistent infectious aggressions. (3) In the last 14 patients with IgM in CSF, a transudation was associated with a local synthesis of IgG (meningitis pattern). (4) A ratio IgM .10(3)/albumin above 10 seems an argument for multiple sclerosis.

Encephalitis↗
PubMed1977

Determination of RNA antibodies in serum and unconcentrated CSF by counterimmunoelectrophoresis.

A quantitative counterimmunoelectrophoresis technique has been applied to evaluation of RNA antibodies in serum and unconcentrated CSF. Serum anti-RNA antibodies have been found at high dilutions in some patients with infectious diseases, subacute panencephalitis and multiple sclerosis. RNA antibodies in CSF are significantly linked to oligoclonal aspect, i.e. to a synthesis of IgG inside the CNS.

Antibodies↗