Search PubMed⌕ Search

Biomedical subjects

E Saling

Publications and source records attributed to E Saling.

At least 109 records · Page 6Linked to original sources
PubMed1981

[The success and complications of antenatal corticosteroid treatment to improve pulmonary maturity: a question of the dosage? (author's transl)].

From January 1978 to December 1979 cortico-steroids to improve prenatal pulmonary maturity were administered to 174 patients. Patients with additional factors to accelerate pulmonary maturity or patients with additional factors to pre-dispose to pulmonary asphyxia during labor were not evaluated. 43 patients who delivered 47 children were studied. The cortico-steroid treatment and delay of delivery for over 48 hours improved the survival chances of the pre-mature infants. Following the administration of 4 times 2 mg beta-methasone-phosphate 26.7% of the infants had respiratory distress syndrome whereas no respiratory distress syndrome was found after 4 times 4 mg of beta-methasone-phosphate.

Betamethasone↗
PubMed1981

[Human placental lactogen and free estriol in maternal blood before and after external version of the fetus from breech to vertex presentation near to term (author's transl)].

In 51 patients with 53 external versions of the child from breech presentation to vertex presentation near to term under tocolysis, the maternal serum-level of human placental lactogen (HPL) and free estriol (E3) was examined immediately before attempting the version and also 30 minutes and 60 minutes after the version, in order to find out whether these two parameters vary according to stress made on the placenta and fetus. In the whole group these were no significant differences in the HPL and estriol levels 30 and 60 minutes after the version compared with the levels before the version. Furthermore comparisons made with attempted versions with heavier stress on the placenta, such as anterior wall placenta, small volume of amniotic fluid, longer duration of the version, and placenta insufficiency did not lead to any significant HPL or estriol decrease in these groups.

Breech Presentation↗
PubMed1981

[Measurement of motor nerve conduction for precise maturity determination in low birth weight newborn infants].

Between 1.10.1979 and 31.1.1981, maturity estimation tests were conducted on 379 eutrophic and 78 hypotrophic neonates at the Department of Obstetrics in Berlin Neukölln by means of motor nerve conduction velocity (NCV) combined with the FARR system. In both eutrophic and hypotrophic infants the median of the nerve conduction velocity rises almost in a straight line from 16.5 m/sec in the 34th week of gestation to 25.7 m/sec in the 41st week. The significance calculation of the nerve conduction velocity of both groups showed no variation (p less than 0,01). On the other hand the maturity estimation made with the FARR system deviated strongly in a false positive direction up to the 38th week of gestation. The measurement of the motor nerve conduction velocity of the ulnar nerve has proved to be a simple and very precise estimation of the postpartum gestational age which makes it possible to distinguish with certainty between premature eutrophic infants and hypotrophic infants of low birthweight.

Gestational Age↗
PubMed1981

A new test-combination for the enzymatic determination of fetal lung maturity.

Based on the enzymatic method for the determination of lecithins, clinical tested by DIEDRICH and coworkers [1], there is a test-combination available now which is soon to be brought onto the market by the film Boehringer, Mannheim, Germany. Full working instructions are given with the test. The biochemical basis of the method is the decomposition of the lecithins in amniotic fluid--which originate from the fetal lungs--by means of a phospholipase C. In an enzymatic chain reaction the split phosphorylcholine as a parameter of lecithins is determined quantitatively photometrically by consumption of NADH. Measurements are made against a reagents blank and Precilip EL (BOEHRINGER, Mannheim) as a quality control. The test set can be used for some months with a maximum of 30 single determinations. In a double-blind study the enzymatic method was tested against the densitometric determination of lecithins by KYNAST and SALING [2]. The examination of 39 amniotic fluid samples which were won by amniocentesis at about the 30th to 42nd week of gestation showed a highly significant relationship (p less than 0.001) between both methods. Meconium and blood raised the lecithin level so that these contamination can lead to false positive values. As a result the examined test-combination is a usable method for determining fetal lung maturity from uncontaminated amniotic fluid samples. Because of its specificity and small apparative costs, it further is suited as a standard comparison method to those other existing methods and may lead to standardisation of lung maturity diagnosis.

Amniotic Fluid↗
PubMed1981

[Early total occlusion of os uteri prevent habitual abortion and premature deliveries (author's transl)].

Repeated late abortions and high-risk, low-chance premature births are among the problems of obstetrics and perinatal medicine still to be solved. It seems that a solution is on its way, through the early total occlusion of the os uteri introduced by us - a solution for at least some of these highly problematic cases. The special advantage of this measure is considered to be the avoidance of an infection ascending to the cervix and to the lower egg-pole resulting in abortion or premature birth. Early total occlusion of the os uteri has been performed on ten women; three have since been delivered of healthy children approximately at term. Six further pregnancies are proceeding normally, five without any phenomena worth reporting, so that further successes can be expected. In one case the external os uteri has become recanalized, and there are premature contractions. In one patient premature delivery occurred after 24/5 weeks of pregnancy with subsequent death of the highly immature newborn post partum.

Abortion, Habitual↗
PubMed1981

[External version of the foetus from breech presentation in patients in condition following abdominal caesarean section (author's transl)].

Since 1974 we have performed more than 500 external versions of the fetus from breech to vertex presentation under tocolysis near to term. Among these were 20 patients who had previously had a caesarean section; in 15 cases the version was successful and in 5 cases unsuccessful. There were only 4 cases of short-lasting bradycardia or slight longer-lasting tachycardia in the cardiotocograms. Twice complications occurred (once vaginal bleeding and once umbilical cord presentation) which did not lead to serious consequences. After successful versions made on 15 patients, 10 patients could be delivered vaginally and 5 were delivered by caesarean section. Based on our first results we are of the opinion that a previous caesarean section is not an absolute contraindication for performing an external version.

Anesthesia, Inhalation↗
PubMed1981

[Measurement of the motor nerve conduction rate: a precise method of assessing newborn maturity? (author transl)].

During the period 1.10.1979 to 31.1.1981 508 maturity determinations were carried out in 483 infants at the Department of Medical Obstetrics of the Neukölln Hospital in Berlin, using the motor nerve conduction rate of the n. ulnaris in combination with the FARR schema. The median value of the NCR increases from 13.0 m/sec in the 33rd pregnancy week (PW) to 30.4 m/sec in the 44th PW almost in linear progression by 1.58 m/sec per week. Over the entire range the NCR showed a highly significant correlation (r = 0.946 at p greater than 0.00001) with the gestatory age of the infant, whereas the FARR schema differs up to the 38th PW markedly in false-positive direction. Measurement of the motor NCR of the n. ulnaris is evidently a simple and very accurate method for post-partum determination of the gestatory age.

Birth Weight↗
PubMed1981

[External version of fetus from breech to vertex presentation near term under tocolysis (author's transl)].

Between 10th May 1974 and 31st June 1980, 12960 births were registered at the Maternity Hospital, Neukölln; in 508 patients 536 (3,9%) external versions of the fetus from breech to vertex presentation near term were performed under tocolysis; of these 53% were successful. The incidence of births with breech presentation and/or transverse presentation could be reduced from 5.4% to 3.7% after the introduction of external version. Whilst the localization of the placenta did not influence the success to a great extent, the number of successful versions increased with advancing parity. No fetal death was caused by the version in 508 patients (536 attempted versions). In 11 attempted versions complications occurred in the form of early partial separation of the placenta and/or umbilical cord presentation. Experience and a more circumspect approach led to a definite decrease in the number of complications. As a result of our findings - and bearing in mind the contraindications and observance of safety measures - the external version can be recommended as a simple method of reducing the risk to infant and mother in the treatment of breech presentations.

Breech Presentation↗
PubMed1980

[Is spectrophotometric analysis of the amniotic fluid a simple method for the determination of fetal pulmonary maturity? (author's transl)].

The samples of amniotic fluid from 55 transabdominal amniocenteses were examined with a simple spectrophotometric test for the predictive value on the risk of respiratory distress syndrome. There was a highly significant correlation between the lecithin content and the optical density of the amniotic fluid at 650 nm (r = 0.065 at p <0.001). No infant with an extinction threshold value of less than 0.15 had neonatal respiratory distress syndrome.

Amniocentesis↗
PubMed1980

Lecithin Content of amniotic fluid in twin pregnancies with and without long-term tocolytic therapy.

During the period from January 1973 to October 1979, 55 transabdominal amniocenteses were performed on 40 twin pregnancies and the lecithin content of the amniotic fluid obtained was established in order to determine the fetal lung maturity. The lecithin determination was performed densitometrically according to Kynast and Saling. Through long-term tocolysis in twins the surfactant production rate is delayed in each phase of the pregnancy, whereas in a collective without long-term tocolysis one can reckon with sufficient fetal lung maturity from the 35th week onwards.

Adrenergic beta-Agonists↗