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Biomedical subjects

E Saling

Publications and source records attributed to E Saling.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Fetal magnetoencephalography I: 1st prenatal registration of auditory evoked neuromagnetic fields].

Using a SQUID gradiometer of the second order, we succeeded in recording a prenatal auditory evoked neuromagnetic field in the 35th week of pregnancy. After sonographic localization of a suitable recording site on the fetal skull, the neuromagnetic field was recorded above the mother's abdomen. It will be necessary to develop special gradiometer configurations for further prenatal registrations of the stimulus-related and spontaneous fetal brain activity.

Electroencephalography↗
PubMed1983

[Home delivery or hospital delivery--a statement free of ideologies].

Due to the progress in obstetrics during the past 20 years hospital deliveries are becoming considerable less risk for mother and child if compared with prior times. On the other hand, individual emotional needs of mother and child are supposed to be relatively more attainable at home deliveries. From the movement to deliver at home obstetrician should learn how to achieve an emotional atmosphere during hospital delivery. Finally we may suggest as a compromise between home and hospital deliveries, out patient management of the same.

Ambulatory Care↗
PubMed1983

Cervical ripening with intracervical prostaglandin-E2 gel. I. Clinical results and effect on plasma levels of oxytocin and 13,14-dihydro,15-ketoprostaglandin-F2 alpha.

Tylose gel containing 400 micrograms prostaglandin E2 in 3 ml gel was injected into the cervical canal of 20 patients with high-risk pregnancy and indication for induction of labor, but with unfavorable cervix. Ten were studied after the first gel application, five during repeat injection, and five after application of gel without PGE2. Blood samples were drawn serially during the first 8 hours for determination of oxytocin and 13,14-dihydro,15-ketoprostaglandin-F2 alpha (PGFM). The PGE2 gel increased the Bishop score within 8 hours in all patients; in half of them, artificial rupture of the membranes could be performed and labor induced without further gel application; in the others, it was repeated every 8 hours until a Bishop score of greater than or equal to 8 was achieved. Fourteen of the 15 PGE2-induced patients delivered vaginally. Mean PGFM levels did not increase significantly during the 8 hours of observation, but in patients who responded with rapid progression, an increase was seen after cervical dilation was 6 cm or more. The mean oxytocin levels increased within 60 minutes after PGE2 application and were increased for the remaining observation period. Application of inactive gel had no effect on cervical ripening nor on oxytocin or PGFM levels.

Adult↗
PubMed1983

[Transcutaneously measured carbon dioxide partial pressure in non-hypoxic fetuses during labor].

Using the newly developed Severinghaus electrode we performed measurements of the transcutaneous carbon dioxide partial pressure (tcPco2) in 81 non-hypoxic fetuses during labor. The calibration and measuring temperature was 39 degrees C. After a correction with a factor of 13% the transcutaneous Pco2 values corresponded well with the blood values of the Pco2 from FBA respectively the umbilical artery. While during the first stage of labor we found only a gradual rise in the tcPco2 level, we observed a rapid rise at the end of the second stage. Analysing the influence of clinical factors on the fetal tcPco2 level we found statistically significant higher levels during the first stage of labor in primipara compared with multipara. However there was no significant difference dependent on gestational age, the age of the mother and the birthweight.

Birth Weight↗
PubMed1983

[Oxytocin (OT) and 13,14-dihydro-15-keto-PGF2 alpha (PGFM) levels after intracervical administration of PGE2 gel combined with administration of beta mimetics; biochemical changes and clinical consequences].

Intracervical application of 0.4 mg PGE2 gel for achieving maturity of the cervix before necessary inducement of labour results in 1-2% of the cases in permanent contractions in association with foetal bradycardias (Goeschen and Saling, 6). This Complication can be removed by the administration of the beta-mimetic Fenoterol given by the intravenous route. Basing on this fact we tried to find out whether it would be possible to prevent an increase in labour activity by administering Fenoterol before applying PGE2 without impairing the softening effect, and also how the OT and PGFM concentrations in the plasma are affected. To clarify this, we compared the clinical and biochemical results obtained in 5 patients who had been given 5 mg Fenoterol orally before receiving 0.4 mg PGE2 gel, with the results obtained in patients who had been treated without any previous Fenoterol administration with either 0.4 mg PGE2 (n = 10), 0.8 mg PGE2 (n = 6) or placebo gel (n = 5). In all groups treated with the preparation were obtained significant differences compared with the placebo group in respect of maturation of the cervix. Oral administration of Fenoterol did not produce any weaking of the softening effect; an increase of the dose to 0.8 mg did not result in an enhancement. After intracervical administration of 0.4 mg PGE2 gel the PGFM values remained unchanged with and without Fenoterol administration; the same was true also after 0.8 mg PGE2 and after placebo. As with spontaneous labour, a significant PGFM increase was seen only if the cervical diameter had attained 7 cm or more.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Topical↗
PubMed1983

Motor nerve conduction velocity for assessment of gestational age in twins.

During the period from October 1, 1979 to March 31, 1981, 40 maturity tests were made on 20 pairs of twins at the Department of Obstetrics at Berlin-Neukölln Hospital. We therefore used the motor nerve conduction velocity (NCV) of the ulnar nerve combined with the Farr system. Only those children whose gestational age was absolutely certain were examined. A strong correlation emerged between the NCV level for twins and singles (r = 0.8 at p less than 0.0001), so that it was possible to establish the maturity age of twins to an accuracy of +/- 1 week. The levels of the NCV measurement within a pair of twins showed a high degree of agreement (r = 0.9 at p less than 0.0001) in which the average fluctuation amounted to 0.5 m/s = 2-3 days. Even when there was a large variation in the weight of the twins (greater than 300 g or greater than 15%), there were only minimal differences (r = 0.9 at p less than 0.0001). On the other hand, the Farr system deviated significantly in a false-positive direction up to the 38th week of gestation. Measuring the motor NCV of the ulnar nerve proved to be a simple and precise method to assess the neonatal gestational age in twins.

Body Weight↗
PubMed1983

Prevention of fetal growth retardation by buffy-coat transfusions--a case report.

A case is described with two previous unsuccessful pregnancies (one missed abortion and one severe fetal intrauterine growth retardation ending in fetal death). Examination showed that the patient and her husband each share one antigen of the HLA-A and -B series. In spite of two previous pregnancies the patient had no lymphocytotoxic antibodies. The patient then received 5 buffy-coat-pool transfusions and the sera reacted with an increasing number of panel cells (Fig. 1). A mature healthy infant was born at term. We consider that the cytotoxic antibodies achieved, took over a protective function for the later undisturbed progress of the pregnancy. This may be a possible way of preventing intrauterine growth retardation caused by immunologic factors.

Abortion, Threatened↗
PubMed1982

[Induction of cervix maturation by oxytocin vs. PGF2 alpha infusion, vs. intracervical PGE2 gel in risk cases with immature cervix].

From April 1, 1978 to March 31, 1979 199 patients with a high risk pregnancy and a Bishop score of less than 7 among a total number of deliveries of 2075 needed induction of labour for medical indications. In 143 patients oxytocin infusions were given, in 56 patients PGF2 alpha infusions were given. It was shown that PGF2 alpha by infusion showed no advantages over oxytocin infusions. The duration of labour and delivery was not shortened. The foetal morbidity was not decreased. The incidence of Caesarean section remained unchanged at a high 32% and the incidence of vaginal operative delivery remained high at 50%. The incidence of post-partum acidosis in the newborn remained at around 14%. Therefore induction of labour was tried on the unripe cervix in the following 12 months with the intra-cervical application of 0.4 mg. PGE2 gel in 202 patients. The same criteria of high risk pregnancies and unripe cervices were used in the following 12 months. In contradistinction to the induction of labour with oxytocin infusion or PGF2 alpha infusion statistically very significant differences in favor of PGE2 gel were found. The foetal morbidity during labour, the duration of labour, the mode of delivery, the neonatal morbidity and the post-partum maternal condition regarding haemoglobin and pyrexia were improved. The low incidence of Caesarean section at 8% and the low incidence of post-partum acidosis in the newborn was especially noteworthy in the PGE2 gel group. Although excellence of prenatal care is essential for the improvement of obstetric results the timely termination of a high risk pregnancy is the second important step to reduce maternal and foetal morbidity. PGE2 gel intracervically improves this second step.

Berlin↗
PubMed1982

[Late cardiac sequelae in children following long-term tocolysis with fenoterol and verapamil].

Premature labour has been treated with Fenoterol and Verapamil since 1970 in the Working Team of Perinatal Medicine of Berlin Free University/Municipal Gynaecological Clinic at Berlin-Neukölln. Elective necroses of the myocardial fibres after stimulation with high concentrations of beta 2-sympathicomimetics have been demonstrated in animal experiments and in isolated foetal myocardial preparations in vitro. It is claimed that such lesions can be avoided by the additional administration of Ca2+ antagonists. Fenoterol and Verapamil will pass the placental barrier. In order to clarify whether long-term tocolysis may exercise an effect on the foetal myocardium, the authors examined 140 children. 78 children of mothers treated with long-term tocolysis were compared with 62 children of mothers who had not received such treatment. The systolic time intervals were measured in full-term children born between 1970 and 1974 and aged 6 to 10 years. Following recording of the case history and physical examination, the ECG, phonocardiogram as well as the carotid sphygmogram were recorded. The frequency rate of abnormal ECG findings (RVL, AV block of the first degree, WPW syndrome) in the tocolysis groups did not differ from that of the untreated control group. Besides, the myocardial contractilities of both groups were also not different from each other.

Arrhythmias, Cardiac↗
PubMed1982

[A new ECG electrode concept for the conduction of fetal heart action potentials without penetration of the skin].

Internal cardiotocography is an important method for reliable supervision of the fetus during labor. The main task is the prevention of fetal hypoxia. However, there is a considerable disadvantage as the electrodes used penetrate the fetal skin, creating a possible entry point for organisms. The concept we have developed forms a new way of decreasing the risk of infection during labor by conducting the fetal heart rate potentials without penetrating the skin. The electrode is fixed to the skin of the presenting part by tissue adhesive and electrical contact between the fetal skin and the wire of the electrode is established through using electrolyte fluid.

Electrocardiography↗