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Biomedical subjects

E Sachs

Publications and source records attributed to E Sachs.

49 records · Page 3Linked to original sources
PubMedDate not supplied

Recombinant leukocyte interferon treatment of chronic hepatitis B.

We have investigated the efficacy of a relatively prolonged course of recombinant leukocyte interferon treatment in 14 chronic HBsAg-, HBeAg-, hepatitis B virus DNA- and DNA polymerase-positive carriers. alpha-Interferon was administered for 9 weeks. Six of 14 treated carriers have a sustained loss of HBeAg, hepatitis B virus DNA and DNA polymerase. Four subsequently lost HBsAg (28.5%). Elevated pretreatment SGPT concentrations, histologic chronic active hepatitis, an exacerbation of chronic hepatitis with an increase in SGPT concentrations in the last weeks of treatment and possibly recent onset of the carrier state was associated with complete inhibition of viral replication. None of 11 matched, untreated HBsAg-, HBeAg-, hepatitis B virus DNA- and DNA polymerase-positive carriers monitored during the same period lost HBsAg. The effect of recombinant leukocyte interferon may require an appropriate host-immune response. The efficacy of recombinant leukocyte interferon therapy is restricted, but it may be of benefit in a proportion of carriers, if these carriers can be precisely identified.

Adult↗
PubMedDate not supplied

Auditory brainstem response and eighth nerve lesions: a review and presentation of cases.

A review of salient features in the use of auditory brainstem response for the detection of eighth nerve lesions is presented. Three cases of acoustic tumors are discussed. These cases represent a normal pure-tone audiogram, one with a moderate loss, and one with no measurable hearing on the affected side. Interpretation of the auditory brainstem response in these cases is discussed in light of the various auditory brainstem response measures presented and the pure-tone audiometric data.

Adult↗
PubMedDate not supplied

Validation study on medical recording practices in primary care clinics.

The validity of records of visits to physicians was studied in three primary care clinics in Beersheba, Israel. A wide variation was found between clinics in the completeness of recording and in the proportion of records that could not be found. The results suggest that data on clinic utilization obtained by an analysis of records may be an underestimate. They should be used only if completeness of recording has been tested and found satisfactory.

Ambulatory Care Facilities↗