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E Sacher

Publications and source records attributed to E Sacher.

21 records · Page 2Linked to original sources

[Interactions between macromolecular adjuvants and drugs. Part 17: On the effect of macromolecular adjuvants on the dissolution rate of chlorpromazine from dosage forms (author's transl)].

The determination of the dissolution rate of chlorpromazine from tablets and triturations containing macromolecular adjuvants by means of a modification of the flow-through type cell according to Langenbucher evidenced a decrease in the dissolution rate produced by polyvinylpyrrolidone, methyl-cellulose and hydroxyethyl-cellulose. It was found that the decrease in the dissolution rate is not due to the confirmed, relatively marked tendency of chlorpromazine to form complexes, but to gel formation.

Adjuvants, Pharmaceutic↗