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Biomedical subjects

E S Mach

Publications and source records attributed to E S Mach.

At least 37 records · Page 2Linked to original sources
PubMed1999

[Antibodies to various phospholipids in SLE patients with primary antiphospholipid syndrome].

Antiphospholipid antibodies (aPL) represent a heterogeneous population reacting with negatively charged, less frequently neutral phospholipids and/or phospholipid-binding serum proteins. The study was made of antibodies to a wide spectrum of phospholipids: to negatively charged phospholipids such as phosphatide acid (aPA), cardiolipin (aCL), phosphatidylcholine (aPS), phosphatidylinositol (aPI), phosphatidylglycerol (aPG) and to neutrally charged phospholipid--phosphatidylcholine (aPC)--in 54 patients with systemic lupus erythematosus (SLE) and 29 patients with primary antiphospholipid syndrome (PAPS). The test for lupus anticoagulant (LAC) was also made. aPL in SLE patients free of antiphospholipid syndrome were detected in 61, 36 and 9% (aPC, aPS and aPA, aCL, respectively). aPI and aPG did not exceed normal values. 81% of SLE patients with antiphospholipid syndrome were LAC positive and 88% aPL positive. 60, 53, 44, 40, 13 and 17 were positive to aPC, aPA, aPS, aCL, aPG and aPI, respectively. Among patients with PAPS, the highest positivity was by LAC, occurrence of the other aPL was the same as in SLE patients with antiphospholipid syndrome. aCL, aPA, aPC, aPS, aPG and aPI were found in 55, 52, 41, 38, 31 and 21% of cases, respectively. In clinical manifestations of antiphospholipid syndrome and negative tests for LAC and aCL it is advisable to make tests for aPS and aPC. aPC occur in SLE patients more frequently than the other aPL: in 63% of SLE patients free of antiphospholipid syndrome and in 60% of SLE patients with this syndrome. Antibodies to other phospholipids, but not to cardiolipin, were present in SLE + APS in half of the cases but in SLE + PAPS in one third of the patients. Occurrence of aCL in the serum of SLE + PAPS patients is associated with the presence of antibodies to any other phospholipid irrespective of the charge. The severity of vascular changes did not correlate with the number of aPL variant found in the serum.

Adolescent↗
PubMed1999

[Thrombo ASS in the prophylaxis of vascular disorders in antiphospholipid syndrome].

The aim of the study was to try thrombo ASS in combined therapy of patients with antiphospholipid syndrome (APS), to evaluate its efficacy in prevention of recurrent vascular defects. Thrombo ASS tablets (50-100 mg) were included in combined treatment of 45 patients with APS (6 males and 39 females, mean age 36.1 +/- 11.7 years, mean APS duration 10.2 +/- 9.0 years) and 8 patients with SLE (1 male and 7 females) matched for age. Antiphospholipin antibodies and clinical status were assessed before treatment and after the treatment within 9 months. It was found that addition of thrombo ASS to combined treatment of APS improves coagulation and microcirculation due to effective muscular blood flow, increases number of platelets in peripheral blood. Tablets covered with coating resistant to gastric juice reduce frequency of gastric side effects.

Adult↗
PubMed1998

[Madecassol treatment of systemic and localized scleroderma].

AIM: The trial of efficacy of 6-month therapy with madecassol (tablets, ointment, powder) of patients with systemic and focal scleroderma (SS and FS). MATERIALS AND METHODS: 54 patients (49 females and 5 males) aged 15 to 70 years with scleroderma running from 3 months to 15 years entered the study. 30 patients had typical SS, 24 patients had FS. Tablets were given to 18 patients, ointment was applied in 42 patients, powder in 3 and tablets + ointment in 9 patients. Madecassol 10 mg tablets were taken 3 times a day by patients with SS and advanced FS. The ointment was preferred in ulcers and scars on fingers and toes in SS and vascular trophic lesions in FS. In active focal scleroderma the ointment was applied to the skin lesions. The ointment was used 2 times a day (in the morning and evening) for 1-6 months. Madecassol powder was employed rarely, primarily of anal and vulval lesions. RESULTS: 6-month oral course (30 mg/day) in 12 SS patients brought about a decrease of indurative lesions, hyperpigmentation (8), vascular trophic disorders (6) and improvement of general condition (5). Subjective response was good in 10 patients and corresponded to absence of progression. In progressive disease and diffuse skin lesions the drug was ineffective. The best response was obtained in local application of madecassol ointment on digital ulcers in SS. CONCLUSION: Madecassol is effective and well tolerated and therefore recommended for oral and local use in combined treatment of SS adn FS. Indications for per os utelization are: chronic or subchronic SS with limited skin involvement, advanced and/or prone to progression FS in which combined administration of the tablets and ointment is proposed.

Adolescent↗
PubMed1997

[Methods for the instrumental diagnosis and verification of Lyme arthritis].

We used instrumental methods to characterise Lyme arthropathy in 79 patients with joint involvement and history of Lyme borreliosis. All of them had arthralgia and 45 of them also had arthritis. Radiological examination has established subchondral bone sclerosis in sacroiliac joints in 68% and sacroiliitis in 29% of the examinees. Scintigraphy revealed polyarticular lesions in many cases. Ultrasound investigation has found inflammation and edema of periarticular tissues in the knee, shoulders and hips. The level of antibodies against the causative agent Borrelia (in EIA) was significantly higher in patients with marked signs of inflammation in ultrasound examination. Thus, the combined methods of examination in the diagnosis of Lyme arthritis provide the most complete information.

Arthritis, Reactive↗
PubMed1997

[The local therapy of enthesitis and bursitis of the calcaneal area in seronegative spondylarthritis].

Four methods of local treatment of calcaneal enthesopathy and bursitis (hydrocortisone phonophoresis, laser radiation, glucocorticosteroids injections into the calcaneal region, physiotherapy with sinusoidal modulated currents) were tried in 69 patients with seronegative spondylarthritis. Local injections of glucocorticosteroids produced the best effect. Laser therapy or hydrocortisone phonophoresis is recommended in dominating pain syndrome in the calcaneal region. SMC therapy was not good in inflammation of tendinous-ligamentous system and calcaneal bursas in patients with spondylarthritis.

Adult↗
PubMed1996

[Muscular pathology in rheumatoid arthritis: a clinico-morphological study].

Muscular pathology was studied clinically, electromyographically, at light microscopy and assessment of tissue microcirculation in 34 patients with significant RA. 22 patients had systemic manifestations, in 12 patients articular lesions predominated. It was found that RA patients with systemic signs had more advanced muscular pathology, more frequent generalized amyotrophy, declined muscular function, low capacity of microcirculatory bed. These patients showed primarily vascular disorders. In RA patients with articular lesions muscular affections become more evident.

Adult↗
PubMed1995

[Vasculopathy in patients with systemic lupus erythematosus and the antiphospholipid syndrome].

Clinicomorphological examination covered 100 patients with confirmed SLE: 79 with concomitant APS (group 1), 21 free of APS (group 2). In group 1 thrombolytic complications occurred in 75%, in group 2- in 13%. The recurrences were more frequent in group 1. Overall percentage of arterial and venous thromboses was approximately the same. According to biopsy and autopsy 2 kinds of morphological changes were found: typical for SLE and APS. Morphological specificity of APS manifested with proliferative and thrombotic changes in both arteries and veins.

Adolescent↗
PubMed1995

[The clinical instrumental characteristics of the locomotor involvement in patients who have had Lyme disease].

Locomotor system has been studied in 24 patients with a history of Lyme's disease. All of them had arthralgia, 11 had relapsing arthritis, chronic arthritis occurred in 6 examinees. Arthritis presented as recurrent asymmetric mono-oligoarthritis affecting primarily joints of the lower limbs. Periarticular disorders were detected in 12 patients. Serologically, 18 of 24 patients had elevated titers of antibodies to Borrelia burgdorferi in indirect immunofluorescence test. Scintigraphy revealed polyarticular lesions in many cases, ultrasound investigation of the joints confirmed inflammatory nature of the pathological changes. It is inferred that combined methods of examination in diagnosis of Lyme's arthritis (titers to antibodies to Borrelia burgdorferi, ultrasound investigations, scintigraphy of the joints) provide most complete information.

Adolescent↗
PubMed1994

[An assessment of tissue microcirculation in patients with aseptic femur head necrosis in rheumatoid arthritis].

Tissue microcirculation above the area of hip joint projection was investigated by 133Xe clearance from the tissue depot and laser-Doppler flowmetry in 38 rheumatoid arthritis patients with complicating aseptic necrosis in 69 heads of the femur. The methods proved reliable in diagnosis of the above microcirculatory disorders and in staging osteonecrosis. Combined use of the procedures was found effective in detection of early circulatory disorders and early aseptic necrosis.

Arthritis, Rheumatoid↗
PubMed1994

[The cerebral blood circulation in patients with systemic lupus erythematosus and the antiphospholipid syndrome].

Ultrasonic duplex scanning was employed to examine cerebral circulation in 50 patients suffering from significant lupus erythematosus (SLE). Of these, 25 patients were with antiphospholipid syndrome (APS) and 25 were without APS. The patients with APS showed a decrease in the total cerebral circulation and a higher percentage of arterial blood flow asymmetry as compared to the patients without APS. The method expands potentialities of the diagnosis of central nervous system damage associated with SLE.

Adolescent↗
PubMed1991

[Acute rheumatic polyarthritis in young men].

As many as 200 patients with acute rheumatic fever were examined. Impairment of the joints in the form of classic migrating polyarthritic was detected in 96% of the cases. The knee (in 80%), talocrural (in 72%), slightly rare radiocarpal (in 21%), and elbow joints were mostly damaged. In addition to the above-indicated damage to the joints, one could see slightly atypical injuries in the form of monoarthritis (in 4%), arthritis of small articulations of the feet and hands (in 6%), and of the sternoclavicular articulations (in 3.5%). According to the cytological, biochemical and immunological findings, synovial fluid obtained from 11 patients suffering from acute rheumatic fever did not differ, significantly from synovial fluid of patients with reactive arthritis.

Acute Disease↗
PubMed1991

[Microcirculatory disorders in patients with psoriatic arthritis].

As many as 39 patients with psoriatic arthritis were examined for hemorheology. Of these, 20 were examined at a time for the status of the microcirculatory bed in the skin and skeletal muscle by 133Xe clearance from the interstitial depot and by laser-Doppler flowmetry at the areas of the clinically intact skin. In 10 patients, the plasma blood viscosity was measured. All the test subjects manifested the clinical signs of damage to the vessels of the microcirculatory bed, namely capillaritis of the palmar surface of the hands and/or of the plantar surface of the feet, sensitivity to cold, numbness of the finger tips. A detailed analysis of the individual aggregation characteristics allowed two groups of patients to be revealed: with a decrease and enhancement of aggregation at a shift rate of 2.5 s-1. It should be noted that patients with severe hemorheological disorders showed both changes on the part of the microcirculatory bed (clinical and quantitative) and a rise of the blood plasma viscosity and hematocrit fall. The data obtained indicate that the microcirculatory and related rheological disorders may be implicated in the pathogenesis of psoriatic arthritis.

Adolescent↗
PubMed1990

[Cryoglobulinemia in Sjögren's syndrome].

As many as 130 patients with Sjögren's disease (SD) were examined for blood cryoglobulins during 1977-1982. Cryoglobulinemia was discovered in 25 (19.2%) patients with SD. The clinical manifestations such as severe xerostomia, appreciable increase of the parotid salivary glands, hepatosplenomegaly, purpura, polyneuropathy, lesions of the lungs and kidneys were mostly detectable in SD patients with cryoglobulinemia. Ten cryoprecipitates of SD patients with cryoglobulinemia showed the monoclonal immunoglobulins IgMk-9 and IgA-1. All the patients had high titers of antinuclear antibodies and 90% manifested antinuclear Ro/La antibodies. Over the 5-year period. SD patients with cryoglobulinemia manifested the growth of hepatosplenomegaly, ulcerous-necrotic vasculitis, polyneuropathy, polyneuritis, cerebral vasculitis, lesions of the lungs and kidneys. The development of the grave systemic manifestations of the disease was attended by a decrease of immunological activity and the rise of inflammatory activity. The 5-year survival of SD patients with cryoglobulinemia was 64% against 98% in SD patients without cryoglobulinemia (p less than 0.001).

Adult↗
PubMed1989

[Comparative clinico-immunologic and microcirculation studies in families of patients with type 1 diabetes mellitus and systemic lupus erythematosus].

Presented are findings of comparative studies of the clinico-immunological parameters and the microcirculatory bed status in 17 DM I probands and 37 of their family members and in 17 SLE probands with 54 of their relatives. The DM I families were found to have DM and prediabetic cases, while among the SLE probands' families rheumatic and, less frequently, cardiovascular diseases prevailed. In the DM I probands' families, a significantly greater number of relatives were found to have rheumatoid factor, high IgG level, anti-DNA antibodies, and CIC (as compared to the SLE series). Both DM I and SLE groups demonstrated reduced efficacy of the cutaneous circulation as compared to norm; in the DM I relatives this disorder was more pronounced than in SLE relatives. The degree to which circulatory changes were pronounced was related to immunological disorders.

Adult↗
PubMed1988

[Extracorporeal therapy (hemosorption, plasmapheresis) in the combined treatment of severe forms of Sjögren's disease].

The clinical and laboratory efficacy of the combination of plasmapheresis, hemosorption disease. The combined Sjögren's disease. The combined intensive treatment led to improvement in the cases with disturbances of the peripherial and central nervous system, kidneys, blood vessels (Raynaud's syndrome), joints and muscles. The efficacy of this treatment is proved in cryoglobulinemic and hypergammaglobulinemic purpura and is comfirmed by the reliable decrease of the rheumatoid factor, circulating immune complexes. C-reactive protein and gamma globulins. A positive dynamics of the exocrine glands function and microcirculation is found.

Adult↗
PubMed1988

[Comparative evaluation of the treatment of Sjögren's syndrome with anti-rheumatic preparations].

The paper is devoted to comparative assessment of combined therapy of prednisolone, chlorambucil, chloroquine phosphate and ibuprofen at small doses and its effect on clinicolaboratory signs of Sjogren's disease in 80 patients in the course of 1 and 5 years. Patients of the control group received only local therapy of the parotid glands. The results have demonstrated that combined therapy at small doses of prednisolone and chlorambucil (5 mg + 4 mg) is an effective method of treatment of the stomatological, ophthalmological and articular manifestations of SD and is also capable of preventing the systemic signs of disease. Combined therapy with chloroquine phosphate and ibuprofen neither influenced the clinicolaboratory signs of disease nor prevented disease progression with the development of systemic signs of diseases of various degrees. Disease progression was observed in 80% of patients receiving no basic drugs or receiving chloroquine phosphate+ibuprofen while in groups of patients receiving small doses of prednisolone and chloambucil disease progression was observed in 20% only.

Adolescent↗
PubMed1987

[Treatment of Raynaud's syndrome with calcium entry blockers].

The authors have presented the results of a 14-day open randomized trial of the efficacy of 3 calcium inlet blocking agents: nifedipine, verapamil and phendilin in 61 patients with Raynaud's syndrome. In the group of patients receiving 30-80 mg of nifedipine (20) there was a significant decrease in the frequency and expression of Raynaud's syndrome attacks, a positive effect of varying degree was noted in 19 patients. The drug raised slightly the skin and muscular blood flow and skin temperature. The use of 120-360 mg of verapamil in 21 patients caused no significant inhibition of Raynaud's syndrome and rise of hemocirculation. Phendilin (150-300 mg) though being comparable with nifedipine in efficacy, often produced side-effects resulting in the drug cancellation (8 out of 20). The efficacy of the calcium inlet blocking agents, especially nifedipine, for therapy of Raynaud's syndrome was emphasized.

Adolescent↗