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Biomedical subjects

E Rubinstein

Publications and source records attributed to E Rubinstein.

At least 289 records · Page 16Linked to original sources
PubMed1979

Legionnaires's disease.

The fist case of legionnaires' disease in Israel is described. In a previously healthy woman, the disease was manifested by a rapidly progressive pneumonia, which was unresponsive to conventional therapy. The diagnosis was confirmed by positive serologic tests and the demonstration of the responsbile microorganism in the patient's lung tissue. Legionnaires' disease should now be suspected in patients with unexplained severe pneumonia, even in countries in which this disease has not been previously recognized.

Adult↗
PubMed1979

Yersinia enterocolitica antibodies in thyroid disorders.

Yersinia enterocolitica agglutinating antibodies were present in 42% of 36 patients with thyroid disease and in none of 77 control subjects. Since the frequency of Yersinia infections in Israel is low, the association of thyroid diseases with Yersinia antibodies is of particular interest. The significance of this finding is discussed in view of some recent observations.

Antibodies, Bacterial↗
PubMed1978

Bacterial endocarditis on a prosthetic valve. Oral treatment with amoxicillin.

A patient with endocarditis due to Streptococcus faecalis on an aortic valvular prosthesis was successfully treated using large oral doses of amoxicillin concurrently with intramuscular administration of streptomycin. Oral therapy was employed because of a persistent reaction to intravenously administered antibiotics. Oral therapy for bacterial endocarditis occurring on an artificial valve may be attempted as a last resort when all other accepted therapeutic measures have failed.

Administration, Oral↗
PubMed1977

Motor-car accidents during pregnancy.

Motor-car accidents in the State of Victoria in the years 1973 to 1975 inclusive resulted in five maternal and 27 fetal deaths. Severe maternal injury only occurred in women not wearing seat belts; however, fetal death may well have been due to seat belt injury in 14 subjects. The commonest genital tract injury was placental abruption.. However, uterine rupture was observed on three occasions and these cases are described in detail.

Abruptio Placentae↗
PubMed1977

Infectious complications of burns casualties during the Yom-Kippur War.

During the October 1973 military conflict, 41 burned patients hospitalized at the Sheba Medical Center were closely followed up. All the patients who had burns occupying 20% or more of the body surface developed wound infections. Pseudomonas aeruginosa was the major pathogen isolated. Most infections occurred during the second week following the injury. Serial cultures revealed that only the isolation of Proteus species and P. aeruginosa from wounds could predict an infection caused by those microorganisms. During treatment with gentamicin and carbenicillin a marked increase in carbenicillin-resistant P. aeruginosa and gentamicin-resistant Klebsiella strains was noted. Cross-infections with carbenicillin-resistant P. aeruginosa was not a major cause in the development of resistant strains.

Bacterial Infections↗
PubMed1977

Treatment of ragweed hay fever with intranasally administered disodium cromoglycate.

In a double-blind study the therapeutic effect of a 4% disodium cromoglycate (DSCG) nasal solution was evaluated in thirty-nine patients with acute symptoms of ragweed hay fever. Patients were randomly assigned to the DSCG or placebo group as they presented with allergic rhinitis. Overall, the DSCG was not more effective than placebo in controlling the symptoms of rhinitis or in decreasing the need for concomitant antihistamines or corticosteroids. Among patients with the highest pretreatment serum ragweed-specific IgE (RW IgE) levels, drug-treated patients had some reduction in symptoms as compared to their placebo controls during the peak of the ragweed pollen season. DSCG treatment did not influence the usual seasonal rise in RW IgE. Side effects from both the active and placebo aerosols were frequent but mild. We conclude that DSCG nasal solution used for the treatment of seasonal ragweed allergic rhinitis is relatively ineffective.

Administration, Intranasal↗
PubMed1977

In vitro activity of cinoxacin, ampicillin, and chloramphenicol against Shigella and nontyphoid Salmonella.

The in vitro antibacterial activity of cinoxacin was compared with that of ampicillin and chloramphenicol against 26 strains of nontyphoid Salmonella and 44 strains of Shigella. Cinoxacin was found to have a lower minimal inhibitory concentration than ampicillin and chloramphenicol against all Salmonella and Shigella sonnei strains. Cinoxacin had minimal inhibitory concentrations similar to those of chloramphenicol but lower than those of ampicillin against Shigella flexneri and S. boydii strains.

Ampicillin↗
PubMed1977

Relationship of serum total IgE and cell-mediated immunity in patients with Hodgkin's disease.

Thymus-derived lymphocytes have been shown to play a role in the regulation of IgE synthesis in the rat. Both anergy and elevated serum IgE levels may be present in patients with Hodgkin's disease. Cell-mediated immunity (CMI) was investigated by measurement of delayed skin test reactions with five common antigens. Serum IgE levels were determined at the same time. Impaired CMI was more prevalent in patients in stage III (13 of 15) and IV (15 of 19), as compared to patients in stage I and II (9 of 17). All 12 patients with elevated serum IgE levels (greater than 300 U/ml) had impaired CMI. These findings strongly suggest a relationship between impaired CMI and serum IgE in Hodgkin's disease patients.

Hodgkin Disease↗
PubMed1977

Effect of systemic antibiotics on the microbial flora of the external ear canal in hospitalized children.

The effect of antibiotic therapy and hospitalization on the external ear canal flora was investigated in 131 children. Fifty-eight percent of the patients receiving antibiotic therapy had Gram-negative bacilli or yeasts in their external ear canal, compared with 17% of the patients who were hospitalized for ten days or longer and only 3% of the patients who were hospitalized for short periods. Antibiotic therapy is the major factor in determining the colonization rate of the external ear canal with potentially pathogenic flora. Children under 1 year of age seem to be the most susceptible group to this shift of flora.

Anti-Bacterial Agents↗
PubMed1976

Effect of ragweed hyperimmune human gamma globulin on in vivo and in vitro parameters of ragweed sensitivity.

The effect of ragweed hyperimmune human gamma globulin upon in vitro and in vivo parameters of ragweed sensitivity was examined. In a double-blind study, 40 ragweed sensitive patients were divided into 2 groups and received either ragweed hyperimmune human gamma globulin (treated) or normal pooled globulin (control). Parameters of ragweed sensitivity studied before and following injections of the gamma globulin included skin test and nasal provocation end point titration, specific IgE antibody as measured by the RAST, leukocyte histamine release, total serum ragweed antibody level, and total serum IgE. Changes in measured parameters varied in both groups of patients. In the "treated" patient group, 1 wk later nasal sensitivity decreased significantly, and there was a trend toward decreased histamine release from leukocytes. No discernable effect was noted upon the other parameters. Thus, with the dosage used, the parenterally administered hyperimmune gamma globulin did not influence most measurements of ragweed hypersensitivity. The concept of this therapeutic approach might warrant further investigation.

Adolescent↗