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Biomedical subjects

E Rubinstein

Publications and source records attributed to E Rubinstein.

At least 271 records · Page 15Linked to original sources
PubMed1981

Interstitial fluid concentrations of cefsulodin, azlocillin and carbenicillin.

Cefsulodin, azlocillin and carbenicillin were administered by intramuscular injection to rats in a dose of 100 mg/kg. THe serum concentration in frequent samples after administration was determined and compared with the interstitial fluid (IF) concentration, measured with implanted paper discs enveloped in a dialysis tube. The IF concentration of cefsulodin was significantly higher than that of the other two antibiotics. The AUC in the IF was also larger for cefsulodin.

Animals↗
PubMed1981

The influence of endotoxin-induced pyrexia on the pharmacokinetics of gentamicin in the rabbit.

Endotoxin-induced pyrexia caused a 2-fold increase in the volume of distribution of intravenously administered gentamicin in the rabbit as compared to the basal state (0.13-0.23 and 0.31-0.65 l for the central and peripheral compartments, respectively). Elimination, half-life was prolonged (46 to 90 min control and pyrexia, respectively), total plasma clearance remaining unchanged (4.6 and 4.9 ml/min, respectively). Endotoxin-induced pyrexia caused a significant increase in the serum concentrations and area under the concentration-time curve of gentamicin administered intramuscularly (355 to 704 microgram . min/ml, control and pyrexia, respectively). The increase in gentamicin concentration area under the curve was positively correlated with the temperature load (P less than .01). As total plasma clearance was not affected by pyrexia, the increased serum concentrations after intramuscular injection may be explained by enhanced absorption from the site of administration.

Animals↗
PubMed1980

The effect of dimethyl sulfoxide on tissue distribution of gentamicin.

Dimethyl sulfoxide (DMSO) and getamicin were administered to rats i.p. No significant differences in gentamicin tissue concentrations were found between rats receiving DMSO and gentamicin, and rats receiving gentamicin alone. DMSO does not increase the tissue concentrations of gentamicin.

Animals↗
PubMed1980

Effect of pancreatitis on ampicillin excretion in pancreatic fluids of dogs.

Pancreatic excretion of ampicillin was evaluated in normal dogs and in dogs with induced pancreatis. A 100-mg/kg ampicillin dose administered intravenously induced mean peak serum levels of 100 micrograms/ml, and a 200-mg/kg intravenous dose induced a mean peak serum level of 273 microgram/ml. Ampicillin serum levels did not differ between the group of normal dogs and those with pancreatitis. In normal dogs, the peak pancreatic fluid ampicillin concentration after the 100-mg/kg dose was 0.4 microgram/ml, and that after the 200-mg/kg dose was 2.7 micrograms/ml. In dogs with pancreatitis, the mean peak ampicillin concentration in the pancreatic fluid after the 100 mg/kg dose was 19 micrograms/ml, and that after the 200-mg/kg dose was 38.5 micrograms/ml. Pancreatic fluid ampicillin concentrations were therapeutic in dogs with pancreatitis and subtherapeutic in normal dogs.

Ampicillin↗
PubMed1980

Probably virus-induced epithelial lesions in preinvasive cervical cancer.

There is an urgent need to approach the evaluation and classification of cervical intraepithelial lesions and their cytopathological correlations as specifically as possible. Preinvasive cancer (differentiated and undifferentiated carcinoma in situ) of the uterine cervix, the most advanced stages of cervical intraepithelial neoplasia, should be clearly defined and described, and the diagnostic and therapeutic management including the follow-up of the patients outlined in detail. The present results, based on a material of 524 cone biopsies, clearly indicate the existence of two different types of probably virus-induced epithelial lesions in the two histopathologic groups of preinvasive cancer of uterine cervix.

Carcinoma in Situ↗
PubMed1980

Necrotizing external otitis.

Necrotizing external otitis in an infant receiving cytostatic therapy for neuroblastema has been described. The disease is characterized by invasion and necrosis of the skin and cartilage of the external ear. P aeruginosa is the usual pathogen isolated in this infection. The disease should be suspected in infants with severe underlying conditions and who have external otitis that does not respond to local therapy. Vigorous antibiotic therapy and possible surgical intervention are indicated.

Cryosurgery↗
PubMed1979

Amphotericin B and 5-fluorocytosine penetration into blood and fibrin clots.

The fungicidal effect of amphotericin B and 5-fluorocytosine (5-FC) on fungi incorporated into blood and fibrin clots was investigated. Amphotericin B was ineffective against fungi incorporated into blood clots, but effective in the eradication of fungi in fibrin clots. 5-FC was ineffective both against fungi incorporated in blood clots as well as in fibrin clots. The combination of 5-FC and amphotericin B was likewise ineffective against fungi incorporated into blood clots. The failure of these drugs to penetrate blood clots may explain the treatment failure in fungal endocarditis.

Amphotericin B↗
PubMed1979

Containment of the femoral head in Legg-Calvé-Perthes' disease and its prognostic significance.

The treatment of LCPD employs to an increasing degree the containment principle, in the form of femoral osteotomy, based on the hypothesis that the factor decisive for the prognosis is centralization of the femoral head, and not relief of weight-bearing by the hip. A follow-up of 48 unilateral LCPD hips treated by strict bed-rest showed a poor correlation (best value r=-0.385) between the degree of lateralization of the femoral head (the migration percentage) during the course of the disease and the spherical quotient at follow-up 12.6 years after the onset of the disease. The results reported, such as shortening of the fragmentation phase and a not unequivocally good outcome of intertrochanteric femoral osteotomy in hips "at risk", may therefore not be due to the containment principle, but perhaps to an improved venous drainage from the femoral head.

Bed Rest↗
PubMed1979

Clindamycin excretion in the pancreatic fluid of dogs.

Clindamycin phosphate in dosage of 15 mg/kg was administered intravenously to dogs. Serum and pancreatic juice clindamycin concentrations were assayed. Pancreatic juice clindamycin concentrations varied between 1.32--5.5 micrograms/ml. Clindamycin was still detectable in the pancreatic juice 4 1/2 h after its administration. Clindamycin, in combination with other antimicrobials, may be potentially effective in the prophylaxis and therapy of some of the infectious complications associated with pancreatitis.

Animals↗