Biomedical subjects

E Rosato

Publications and source records attributed to E Rosato.

40 records · Page 3Linked to original sources

PubMedDate not supplied

Retrospective exaggeration of symptoms: vomiting after gastric surgery for obesity.

The possibility that patients may retrospectively exaggerate the severity of complaints that they have experienced has not been systematically investigated. The validity of retrospective reports was called into question by a study of vomiting following gastric bypass surgery for obesity. Such vomiting occurred relatively infrequently--no more than 3.4 times per week, even during the first postoperative month. At a 6-month follow-up, however, some patients reported that they had experienced very high rates of vomiting postoperatively, in direct contradiction to their earlier reports. Such retrospective exaggeration has apparently contributed to the widespread belief that vomiting following gastric bypass surgery is a serious problem. We believe that this report is the first to describe retrospective exaggeration of symptoms. Further research is needed to assess the extent of this problem.

Adult↗

PubMedDate not supplied

Significant changes of peripheral perfusion and plasma adrenomedullin levels in N-acetylcysteine long term treatment of patients with sclerodermic Raynauds phenomenon.

The unclear pathogenesis of scleroderma vascular lesions makes treatment of Raynaud's phenomenon (RP) in Systemic Sclerosis (SSc) patients very difficult and a new effective treatment is requested. Recently, a powerful antioxidant agent, the N-acetylcysteine (NAC) has been shown to decrease the frequency and severity of RP in SSc patients. Subsequently, using functional infrared imaging, we showed that a single 1-hour NAC infusion in these patients caused a significant increase of skin temperature. The aim of this study was to demonstrate the efficacy of long term therapy with NAC in an open clinical trial evaluating clinical, instrumental and laboratory parameters. Patients started the treatment receiving for two years, from October to May, intravenous NAC infusions of 15 mg/kg per hour each, for 5 consecutive hours, every two weeks. Before and after each infusion, patients underwent both Laser Doppler perfusion Imaging (LDPI) for the evaluation of the digital perfusion and a blood test to ascertain the plasma adrenomedullin (AM) levels. The NAC infusion increased global hands perfusion and induced a significant decreasing of plasma AM concentrations. Side effects were negligible, easy to control and reversible. Reduction of frequency and severity of RP attacks was recorded. In conclusion, NAC seems to act as an effective vasodilatator in the treatment of RP secondary to SSc and, in addition, it induced significant changes in plasma levels of AM, a potent vasodilator endothelial-derived peptide.

Acetylcysteine↗

PubMedDate not supplied

High incidence of Helicobacter pylori infection in patients with systemic sclerosis: association with Sicca Syndrome.

To test the incidence of Helicobacter pylori (HP) infection in patients affected by Systemic Sclerosis (SSc) a swift urease test, followed by histologic confirmation for the presence of HP was verified in 35 SSc patients. Serum samples from 46 patients were tested for HP IgG antibodies by an enzyme-linked immunosorbent assay. Urease test demonstrated the presence of HP in 23 patients out of 35 (66%); 12 of them were negative to colonization. A Sicca syndrome, with abnormal Schirmers test and dry mouth was detected in 66% of the patients. 78% of the patients with Sicca syndrome had a concomitant HP infection, compared to 42% of those without the syndrome (p=0,029). Altered peristalsis and reduced salivary clearance usually encourage HP infection. In patients with Systemic Sclerosis we found an enhanced frequency of HP infection.

Journal Article↗

PubMedDate not supplied

[The course of varicose disease. Parallel retrospective study of 2 ethnic groups (Catania-Basel)].

Authors presents a retrospective study with two different ethnic groups, one of them from Catania and the other from Basilea, with varicose veins and subjected to a saphenectomy. They studies the following parameters: age at the entrance, and when varicose veins appeared; correlation between varix appearance date and subjective symptomatology; and rapport between varix complications and its duration. The possible incidence of "ambiental factor" and contrasts between the two groups are considered.

Adult↗