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Biomedical subjects

E Richter

Publications and source records attributed to E Richter.

At least 199 records · Page 11Linked to original sources
PubMed1990

Incidence of hypothyroidism after irradiation of the neck with special reference to lymphoma patients. A retrospective and prospective analysis.

Twenty-eight patients were studied prospectively in order to determine the incidence of hypothyroidism after mantle irradiation for malignant lymphoma. This group was compared with a historical group of 65 patients, among them 36 patients with malignant lymphoma. The mean follow-up was 30 months for the prospective group and 46 months for the retrospective group. The mean thyroid dose for irradiated malignant lymphomas in the prospective and the retrospective group was 45 Gy and 43 Gy respectively. For other tumors with neck irradiation (retrospective group) the mean thyroid dose was 53 Gy. There were no cases of clinical hypothyroidism in our study. As for subclinical hypothyroidism which is characterised by elevated TSH, the incidence was 22% in the prospective group and 3% in the retrospective group, i.e. 8/93 patients showed a hypothyroid dysfunction. Three of the 8 patients with subclinical hypothyroidism had undergone lymphangiography before radiotherapy. Due to the elevated iodine pool a lymphangiogram is considered as a risk factor for hypothyroidism as well as for hyperthyroidism, which we observed twice in the prospective group. Evaluation of the thyroid function before lymphangiography and irradiation as well as regular thyroid function studies during the follow-up are recommended in order to detect hypothyroidism in time.

Adolescent↗
PubMed1990

[Mechanical plasmapheresis by means of the Haemonetics-ultralite- plasma collection system: 2. Generation of platelet-rich plasma].

70 plateletpheresis were performed in a clinical study to evaluate the quality of platelet-rich-plasma prepared by the new developed Haemonetics-Ultralite-Plasmacollection system. The procedure took in average 54 minutes, resulting in a platelet content of 1.6 X 10(11) platelets. Platelets function (hypotonic stress response, ADP- and collagen-induced aggregation) was well maintained. The after differential centrifugation prepared platelet concentrate may be stored in the collection bag for 1 day at room temperature with acceptable functional recovery.

Blood Cell Count↗
PubMed1990

[Exclusion chromatography for the separation of cryoprotective agents from freeze-preserved blood cells].

A method for separating low molecular cryoprotectiva from freeze-conserved erythrocyte- and thrombocyte-concentrates by exclusion chromatography has been described. A new vesicular packing material has been used. Only 25 to 30 minutes are necessary in order to separate glycerol respectively dimethylsulphoxide (DMSO) completely from the cells. 86.5% of the erythrocytes and 75.4% of the thrombocytes were recovered after the separation process.

Blood Platelets↗
PubMed1990

[Computed tomographic determination of the target volume and the evaluation of remission after radiation of bronchial carcinoma].

434 CT examinations of 133 patients with histologically proven bronchogenic carcinoma (22 out of 133 with small cell lung cancer) were analysed before and after radiotherapy. The study evaluates the use of CT for determining target volume, tumour volume and remission rate: 1. Concerning determination of target volume conventional roentgen diagnostic simulator methods are much inferior to CT aided planning: as for our patients changes of the target volume were necessary in 50%, in 22% the changes were crucial. This happened more often in non-small cell lung cancer than in small cell carcinomas. 2. The response rate (CR + PR) after radiotherapy (based on the calculated tumour volumes by CT) was 70 to 80%. The rate of CR of the primary was 45% (non-small cell carcinoma) and 67% (small cell carcinoma). 3. The crucial point for the evaluation of tumour remission after radiotherapy is the point of time. One to three months and four to nine months after irradiation we found complete remissions in 19% and 62%, respectively. Hence, the evaluation of treatment results earlier than three months after radiotherapy may be incorrect. We deem it indispensable to use CT for determination of target, calculation of dose distribution and accurate evaluation of tumour remission and side effects during and after irradiation of patients with bronchogenic carcinoma.

Adenocarcinoma↗
PubMed1990

[The radiotherapy of primary extranodal non-Hodgkin's lymphoma of the nasopharynx].

Primary non-Hodgkin's lymphoma occurs quite seldom in the nasopharynx, therefore reports on this topic are rare in medical literature. The treatment results of 30 irradiated patients (40 to 60 Gy) are presented. The period of the study ranges from 1960 to 1985. 13 patients with low grade lymphoma and 17 patients with high grade lymphoma according to the Kiel classification form the basis of this study. The overall actuarial 5-year survival rate is 24%. This also applies for the subgroups of low grade and high grade lymphomas with a 5-year survival rate of 24%, respectively. The evaluation of the patients without generalization in the course of disease shows that the prognosis of stage IE patients with 43% was superior to the one of stage IIE patients with 25% (p less than 0.001). Only patients with lymphoma limited to the nasopharynx survived longer than five years (46%), but none of the patients with simultaneous spread to the nasal cavity, the oropharynx and/or the base of the skull. Local and regional recurrences were rare. However, a generalization of the disease occurred more often (20%), mainly due to insufficient staging in former years. Long-term sequelae of the radiation therapy like rhinitis or pharyngitis sicca were registered occasionally. At present, locoregional radiation therapy is recommended for stage IE and IIE low grade lymphomas and stage IE high grade lymphomas of the nasopharynx.

Aged↗
PubMed1990

[In vivo determination of tumor volume: what does a CT-based calculation mean in recurrences of rectal carcinoma?].

The volumetric analysis of a tumour by CT is a reliable and clinically important method of examination which is rarely used. As for oncology, the importance of this method is based upon the determination of the stage of remission post-therapeutically, especially in those cases which respond to therapy without a roentgenologic change in comparison to pretherapeutic findings. This applies in particular for the evaluation of CT images. In this study 115 CT examinations of 38 patients with recurrent rectal cancer were evaluated and the tumour remission was measured by an exact determination of the tumour volume before and after radiotherapy. The results were compared with the CT findings without volumetric analysis. A change of the tumour size up to 20% of the pretherapeutic volume which eludes from the visual perception can be revealed by a subtle CT-assisted volumetric analysis. Formulas for calculation of the volume or the data concerning length, width and depth of a mass prove to be insufficient or incorrect. Therefore the correct evaluation of a tumour regression or progression should be done more often by CT-assisted volumetric analysis.

Humans↗
PubMed1989

[BVDU therapy in herpes corneae].

The authors report on the results of therapy with 0.1% BVDU eye drops in a pilot study involving 80 patients suffering from stellate, dendritic, and geographic keratitis. Tolerance of this drug was very good. Healing occurred in 66 patients (82.5%) within 14 days. In these patients re-epithelialization was complete after an average of 5.4 days. In 13 patients (16.3%) the lesion took more than 14 days to heal (mean 18.2 days). The therapy must therefore be considered as having failed in these cases. In one patient (1.2%) the treatment had to be discontinued, as his condition deteriorated during treatment with BVDU.

Antiviral Agents↗
PubMed1989

[The role of radiotherapy in endocrine orbitopathy].

The treatment of Graves' ophthalmopathy is symptomatic because the etiology remains unknown though evidence supports an aberrant immune response. Orbital radiotherapy, combined with corticosteroids, is indicated for rapidly progressive ophthalmopathy and troublesome soft tissue symptoms. In case of sight-threatening manifestations operative decompression is the method of choice. However, radiotherapy seems to be a safe and effective method as a good to excellent response in 60-70% of patients can be expected. The treatment results of 15 patients with a long term follow-up are presented.

Adult↗
PubMed1989

[Mechanical donor plasmapheresis using the Haemonetics Ultralite plasma collection system. 1. Collection of fresh plasma].

In a clinical study altogether 449 machine donor plasmapheresis for collection of platelet poor fresh plasma were carried out using the new developed Haemonetics-Ultralite-Plasma-Collection-System. The average time of donation for 600 g of plasma amounted to 36 min. In comparison to other automated plasmapheresis-systems an effective plasma flow is recorded for the Ultralite-machine. All plasmapheresis procedures were well tolerated by the donors. The collected plasma is equivalent to the requirements for fresh frozen plasma. Complications due to the device or donors are small with 2.9% of the performed procedures.

Blood Donors↗
PubMed1989

[The effect of ascorbic acid in preservation solutions on the antioxidative potential of blood plasma during liver transplantation in miniature swine].

The antioxidative potential (AP) of blood plasma was defined for its O2-.-trapping capacity. The superoxide radicals were generated in a photochemical system and detected by luminol chemiluminescence. During the preparation phase of experimental liver transplantation on mini-pig the AP of peripheral blood increased twice. There is a 20-fold increase of AP one hour after the blood recirculation in transplant. An antioxidative defence of organ with ascorbic acid during the cold preservation period removed these increase. The possible mechanisms of the observed phenomena and the information significance of the AP measurement in blood plasma are discussed.

Animals↗
PubMed1989

[Current aspects of radiotherapy of glomus jugulare tumors].

Small glomus jugulare tumors can be operated on successfully. The intraoperative risk of bleeding may be reduced by preoperative irradiation or angiographic embolisation. Patients with advanced tumors (bone destruction, paralysis or cranial nerves and/or invasion of brain) are at high risk if they are operated on. In these cases radiotherapy is an effective alternative with a fairly low complication rate. Prerequisites for successful irradiation are assessment of treatment volume and treatment planning by CT, sophisticated stereotactic irradiation techniques, application of high energy photons and reliable immobilisation measures. Furthermore it is possible to deliver higher doses, leading to regression of the tumor and its symptoms. The technique is illustrated by two characteristic cases. Although irradiation alone can achieve tumor remission the long term prognosis remains doubtful.

Female↗