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Biomedical subjects

E R Nye

Publications and source records attributed to E R Nye.

At least 73 records · Page 4Linked to original sources
PubMed1975

The effect of dietary lipids on lipolysis in rat adipose tissue.

1. Rats were fed for 8 weeks on one of five diets differing in the amount of fatty acids 18:1, 18:2 and 18:3. Lipolysis, in vitro, of epididymal fat from fed and fasted rats was measured both basally and in the presence of noradrenaline with and without prostaglandin E1. 2. Lipolysis was markedly influenced by the type of dietary fat. In particular, lipolysis in adipose tissue from rats given diets rich in the fatty acid 18:3 was higher than in the rats given diets containing 18:2. 3. Results showing the effects of fasting on adipose tissue lipolysis are also presented. 4. The results are discussed in relation to the known effects of unsaturated fats on hyperplasia and protein synthesis in adipose tissue and on the possible role of prostaglandins.

Adipose Tissue↗
PubMed1975

Increased levels of esterified arachidonic acid in plasma by feeding gamma-linolenic acid.

The effects of diets containing 5% of methyl-gamma-linolenate (delta 6,9,12) or 5% of methyl-alpha-linolenate (delta 9,12,15) on the fatty acid composition of lipids in rat plasma were studied. After 10 days the cholesterol esters and total phospholipids in the plasma of rats fed gamma-linolenate contained higher percentages of arachidonic acid than the corresponding lipid classes in the plasma of rats fed the alpha-isomer. A fairly high percentage of gamma-linolenic acid was incorporated into the cholesterol esters of rats fed methyl-gamma-linolenate.

Animals↗
PubMed1970

The mobilization of free fatty acids in relation to adipose tissue triglyceride fatty acids in the rat.

Three diets, consisting respectively of formulations high in oleic and stearic acid, linolenic acid, and lauric acid, were fed to rats until the adipose tissue TGFA largely reflected the dietary pattern of fatty acids. The composition of the serum FFA under basal conditions and following noradrenaline-stimulated lipolysis, were examined in relation to the respective adipose tissue TGFA. It was found in both in vivo and in vitro studies that lauric acid appeared to be less easily mobilized than longer chain acids. The in vitro studies indicated that this could not be explained either by positional preference of the shorter chain acids for the alpha-position of esterification or by increased reesterification of the shorter chain acids. The possibility remains that the difference is due to some specificity of tissue lipases for certain ester linkages.

Adipose Tissue↗
PubMed1969

Short-term effect of nicotinic acid on plasma level and turnover of free fatty acids in sheep and man.

The effects of nicotinic acid on plasma free fatty acid levels and turnover and on plasma glycerol levels were studied in the first few hours after administration to man and the sheep. In both species a fall in all parameters studied was followed by a rise above basal level, interpreted as due to an increase in lipolysis above resting level. The significance of the findings is discussed.

Animals↗