Localized unilateral hyperhidrosis: eccrine nevus.
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Biomedical subjects
Publications and source records attributed to E Quintanilla.
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We report the case of a 61-year-old male who presented with a febrile illness accompanied by arthralgia and myalgia. Two months later he developed multiple subcutaneous nodules and enlarged parotid glands. Later two erythematous plaques, clinically compatible with erythema nodosum (EN), were observed. Laboratory investigations revealed abnormal levels of angiotensin converting enzyme and chest radiography showed bilateral hilar enlargement. The biopsy of the cutaneous lesions demonstrated multiple non-caseating granulomas in the subcutaneous tissue without any alterations in the epidermis and the dermis. The cultures for Mycobacteria and fungi were both negative. The clinical picture and histopathological findings were compatible with subcutaneous nodular sarcoidosis. The response to steroid treatment was satisfactory.
Perianal basal cell carcinoma (BCC) is a rare tumour and only a few case reports can be found in the literature. In this location, it is important to differentiate a BCC from a basaloid cloacogenic carcinoma, as the first is an invasive but localized tumour, while the second has a high capacity for metastasis.
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We report a 69-year-old man with disseminated superficial actinic porokeratosis (DSAP) who developed a hyperkeratotic lesion on the distal third of the right forearm with the characteristic histopathological findings of squamous cell carcinoma and DSAP. A review of the literature revealed only four similar cases.
The inflammatory metastatic carcinoma is a rare clinical entity, histologically characterized by lymphatic dermal invasion by neoplastic cells. We report three cases of inflammatory metastatic carcinoma, two of them secondary to a breast carcinoma, and the third secondary to a colon adenocarcinoma.
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The subepidermal calcified nodule (SNC), included under the idiopathic cutaneous calcifications, is an infrequent cutaneous process. We report a new case localized on the chin of an 18 month old child. We review the concept gathered from previous literature and we post the possible role which the mast cell may play in the genesis of the said deposits.
We present a case of keratoacanthoma type II in a 38-year-old female patient, which developed in the thigh over the donor site of a laminar skin graft, six weeks after the procedure. The graft was utilized to cover the defect secondary to the resection of a melanoma. The possible role played by mechanical trauma in the development of this tumor, rare under such circumstances, is discussed. Similar previously published cases are reviewed.
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Carcinoma of the pancreas is increasing in incidence and affecting a younger population. However, pancreatic carcinoma in children under 15 years of age is a rarity. Only 28 cases were reported in the literature from 1885 to 1981. All of the known patients who have undergone resection of the tumor are alive at the present time. The differential diagnosis of abdominal masses has been further elucidated by abdominal tomography. Pancreaticoduodenectomy or distal pancreatic resections may be fitted to the individual case with reasonable expectations of patient survival.
A review of the classification, localization, symptoms, age of on-set and incidence according to sex of the cutaneous leiomyomas in done. Besides the hereditary aspect and the association of extracutaneous lesions, especially the uterus, are considered. We present the case two sisters affected by multiple cutaneous leiomyoma in association with uterine leiomyoma. Both, members of a family in which the father and 4 of the 8 offsprings present multiple cutaneous leiomyoma, and the daughter of one of the female members (third generation) is also affected of leiomyoma of the uterus. We conclude that the presentation of the leiomyoma in this family is more than a mere coincidence and that there must be some hereditary mechanism, which is interpreted as dominant and the penetrance of the autosomal dominant gene would be about 56%.
We have presented a study of two cases of Mycosis Fungoides with special emphasis on the staging of the disease as well as on the immunological findings and their modification with chemotherapy. Our objective, to relate the immunological response to clinical evolution, proposes a way of determining prognosis in the evolution of this poorly understood disease.
Thirteen biopsies from 8 patients with amiodarone-induced skin pigmentation were studied. Light microscopy showed that skin pigmentation of these patients was produced by solar elastosis, increase of melanin and accumulation of the properly called amiodarone pigment in the upper dermis. The degree of solar elastosis and the amount of amiodarone pigment was related to total doses of amiodarone. This pigment was negative for fat stains and positive for Masson-Fontana stain, and had neither birrefringency nor autofluorescence. Ultrastructurally, the granules of amiodarone pigment appeared as membrane-bound granules with a fingerprint-like lamellated structure, which others have related to lipofuscin. We conclude, however, that this pigment may be a metabolite of amiodarone, morphologically and histochemically related to melanin.
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