The AA. confirm the influence of rifampicin on delayed hypersensitivity phenomena determining its interference on the tuberculin reaction in guinea-pigs sensitized with Freund's adjuvant. In this experimental model rifampicin, either administered during the whole period of sensitization or for shorter periods or even only at the moment of challenge, inhibits the delayed hypersensitivity reactions. Also in man the evolution of citologic reactions connected with PPD stimulation in tuberculous tuberculine-positive patients, studied by the "skin window" method, is modified by a continuous treatment with rifampicin: particularly an inhibition of mononuclear reaction is evident.

Animals↗

PubMedDate not supplied

[Infusion pre-hydration and a humid room in the prevention of postoperative adhesions].

The Authors after an overview on the most important causes of postsurgical adhesions, drove their attention to the tissue injury determined, during abdominal surgery, by exposure of pelvic serosa to the humidity of operating area. The AA tested body temperature in the Douglas pouch and under the liver on 30 patients who were operated by conservative surgery (myomectomy) and on 8 patient who underwent laparoscopy. A decrease of one degree in the Douglas pouch after one hour on the patient who had a Pfannestiel incision has been detected. While on the patients with longitudinal laparotomy no difference was evidenced. Serosal biopsies done at the beginning of surgery after pelvis exposure to the external conditions (temperature, humidity) showed a marked phlogosis in the tissue of the patients not treated at all. These tissue injuries were almost absent in the group treated with saline tissue irrigation and absent in the group that had parenteral prehydration, too. The AA suggested the use of the two techniques in conservative surgery in order to obtain in the open abdomen surgery results similar to those of the endoscopic one.

Body Temperature↗