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Biomedical subjects

E Pozzi

Publications and source records attributed to E Pozzi.

At least 91 records · Page 5Linked to original sources
PubMed1978

On the pathogenesis of bleomycin lung toxicity.

Bleomycin is potentially capable of inducing a diffuse interstitial fibrosis of the lung, the pathogenesis of which has not yet been elucidated. The authors have demonstrated that after 48 hr of acute treatment, morphological and functional modifications could be seen in type II pneumocytes, which are responsible for surfactant production. This might be the earliest stage of pulmonary damage.

Animals↗
PubMed1977

Psychotropic drugs: influence on respiratory function.

The authors investigated, in 22 normal subjects and 22 bronchopneumopathic patients, the action of two anxiolytic drugs on ventilatory function and on the associated respiratory function. The analyses carried out before drug administration and 1, 2, 6 hours later showed that while a drug did not cause any important variation in the ventilatory parameters and O2 uptake, both in healthy subjects and in patients, the second one clearly reduced the ventilatory efficacy and O2 uptake. This behavior was quite evident 1 and 2 hours after the assumption of the drug while after 6 hours the parameters returned to the initial values. The influence of the circadian rhythm after 6 hours was more evident in both groups after the assumption of the second anxyolitic drug than with the first. Furthermore, evaluation drawn up among the healthy subjects, during simulated driving tests, demonstrated that the second anxyolytic drug provoked a standard depression unevenly distributed like that obtained after the ingestion of a fixed dose of an alcoholic drink.

Bronchopneumonia↗
PubMedDate not supplied

Detection of multidrug resistance associated P-170 glycoprotein in previously untreated non small cell lung cancer.

Samples of Non Small Cell Lung Cancer (NSCLC) and normal bronchial tissue obtained in patients submitted to radical surgery and without previous exposure to cytotoxic drugs were investigated for the expression of P-170 glycoprotein using C-219 monoclonal antibody and an immunohistochemistry technique. In normal bronchial tissue the immunostaining was confined to the lumenal surface of the epithelium. Fifteen out of 86 NSCLC had more than 1/4 of examined cells positive for P-170 glycoprotein, but the heterogeneity of the expression ranged from rare scattered cells to a positive pattern for nearly all cells considered, without any relationship with pathologic and clinical prognostic variables.

ATP Binding Cassette Transporter, Subfamily B, Mem↗