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Biomedical subjects

E Ponte

Publications and source records attributed to E Ponte.

At least 73 records · Page 4Linked to original sources
PubMed1979

Correlations between cutaneous and retinal microaneurysms in diabetes mellitus (preliminary note).

A group of diabetic patients was submitted to a capillaroscopic examination at the level of the peri-ungual vallum and to a fluoroangiographic examination of the retina, for the evaluation of possible correlations between vessel conditions in to various districts. The Authors remarked that the subjects affected by proliferative diabetic retinopathy presented a greater dilatation of the ansae at cutaneous level, with haemorrhagic extravasations in 70% of the cases. On the contrary, on the subjects with nonproliferative diabetic retinopathy numerous aneurysmal "buttons" were noted at cutaneous level, both apically and laterally along the vascular ansa.

Adolescent↗
PubMed1979

Contributions toward the study of changes in the microvascular-tissual system in diabetes mellitus (Observations on 50 biopsies of the finger-tip).

Fifty biopsies of finger-tips, from diabetic patients were examined. We wish to emphasize, of damage in the blocking devices and in the preglomic arterioles as opposed to the limited modifications produced in the small dermic and hypodermic arteries. The glomera are almost constantly affected in their various components: in particular, the fusion of the glomic capsule with the intra- and extraglomic connective should be noted, as well as the presence of accumulated P.A.S. positive material among the mioepithelioid cells in the intermediate segment. The capillaries are frequently affected by hyperplasia of the intimal endothelium, sometimes with subocclusive phenomena, while the basal membrane is thickened and P.A.S. positive more often in extraglomic than in intraglomic capillaries.

Adult↗
PubMed1979

Correlations between capillary microscopy and electrocardiographic results in the diabetic.

Ninety-nine diabetics were simultaneously given a capillaroscopic examination of periungual walls and an electrocardiogram evaluated according to the Minnesota Code. From these tests the following data were recorded: a. the number of knobs revealed by capillaroscopy is inferior, in a statistically significant manner, in groups having "major abnormalities"; b. capillaroscopic abnormalities did not seem to be definitely correlated to age, but rather to the length of time diabetes mellitus was present; in particular, these abnormalities were quite evident in subjects diagnosed as diabetics for the first time. This procedure is therefore extremely useful for the early diagnosis of diabetic microangiopathy; c. electrocardiographic abnormalities are correlated to patient's age, whereas are not related to the period of the illness. Although the small sampling obliges us to maintain certain reservations, such abnormalities were more frequent in subjects taking antidiabetic drugs orally.

Adult↗
PubMed1976

[Case of crural ulcer during polycythemia vera].

A case of polycythaemia vera, in which a crural ulcer appeared numerous years after the onset of the disease, is reported. The absence of important angioneurological lesions and the signs at cutaneous lesion level of capillary dilatation, suggest that crural ulcer is a complication of polycythaemia. Aetiopathogenetic aspects are also discussed.

Biopsy↗
PubMedDate not supplied

Thyrotropin-releasing hormone metabolism is attenuated in the cerebrospinal fluid of the human neonate.

The present study was designed to investigate the ontogeny of thyrotropin-releasing hormone (TRH) metabolism in human cerebrospinal fluid (CFS). The activity of pyroglutamate aminopeptidase (EC 3.4.11.8), the major enzyme catalyzing TRH metabolism in human CSF, was measured in CSF of 11 premature infants (gestational age, 29-39 weeks; birth weight, 1774 +/- 274 g), 8 newborn infants (term delivery; birth weight, 3648 +/- 240 g), and 11 adults (mean age, 29.6 +/- 1.5 years). Pyroglutamate aminopeptidase activity in CSF of premature and newborn infants was significantly lower (p less than 0.05) than that of adult CSF. These observed differences in the enzymatic activities were not due to changes in the affinity of the enzyme for its substrate TRH or the presence of enzyme inhibitor(s)/stimulator(s).

Adult↗
PubMedDate not supplied

Venous thromboembolism and renal cell carcinoma.

There is a vast amount of literature documenting the relationship between cancer and venous thromboembolism. Nevertheless, many aspects of this association remain obscure and the best approach to be taken towards a patient with apparently idiopathic venous thromboembolism has yet to be defined. We present a case of a patient with venous thromboembolism in whom abdominal ultrasonography, prescribed as a cautionary measure to rule out the presence of a tumour, revealed liver metastases, while the subsequent CAT scan showed hepatic angiomatosis and two small bilateral renal carcinomas. Although there are as yet no indications in the literature on screening patients with idiopathic venous thromboembolism for occult tumours, our case shows how the clinical decision to perform abdominal ultrasonography saved the patient's life.

Carcinoma, Renal Cell↗
PubMedDate not supplied

Thrombosis and cancer.

Although the association between malignant disease and thrombosis was first recognised by Trousseau in 1865, many aspects of this complex relationship are still obscure. Cancer patients have an increased risk of developing thrombosis. Similarly, patients presenting with idiopathic venous thromboembolism are considered to have a higher risk of developing cancer. However, no data exist that warrant thorough screening for cancer in these patients--apart from history taking, physical examination, routine investigations, and chest X-ray. Tumour cells activate the blood coagulation system either by directly stimulating thrombin formation or by inducing mononuclear cells to synthesise procoagulants. Both cancer cells and chemotherapeutic agents damage the endothelium by further enhancing the hypercoagulable state of malignancy. With few exceptions, the diagnosis and treatment of thrombosis in cancer patients are the same as in patients without cancer. Cancer patients are considered eligible for primary prevention of venous thromboembolism when they are receiving chemotherapy, if they have indwelling central venous catheters, when they are immobilised and, more importantly, when they undergo surgery. Secondary prevention in recurrent venous thrombosis may require the administration of oral anticoagulants or, in cases of resistance to warfarin, adjusted doses of heparin.

Humans↗
PubMedDate not supplied

[Captopril and hydrochlorothiazide in treating arterial hypertension in the elderly patient. An enlarged case series and verification of the results].

A group of 171 hypertensive patients were treated using 100 mg captopril and 50 mg hydrochlorothiazide over a period of four months. The group was subdivided into two subgroups of 138 elderly patients and 33 patients aged under sixty all of whom had a systolic blood pressure of over 180 mmHg, or over 160 mmHg if they had undergone previous treatment using another drug. Patients were monitored after one month and at the end of hypotensive therapy. The study showed a statistically significant reduction of blood pressure in both groups. In the elderly group blood pressure diminished from a mean basal level of 198.8/104.5 mmHg to 140.4/80.5 mmHg, whereas in the adult group pressure values were reduced from 190.1/108.4 mmHg to 134.0/80.6 mmHg. These results match those of an earlier study and, in conclusion, the Authors affirm that this combinations is a suitable "geriatric drug" since it responds to the needs of elderly hypertensive patients. Using captopril and hydrochlorothiazide it is possible to improve the quality of life of elderly hypertensive patients who are otherwise notoriously difficult to treat.

Adult↗