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Biomedical subjects

E Phillips

Publications and source records attributed to E Phillips.

At least 127 records · Page 7Linked to original sources
PubMed1981

Control of urea cycle enzymes in rat liver by glucagon.

A single injection of glucagon increased the levels of all five urea cycle enzymes in 28-day-old rats, but had no significant effect in 35-day-old animals. Rats weaned onto diets varying in protein content showed rapid adaptation in the levels of carbamoylphosphate synthetase, which were complete 4 days after weaning. Induction of the enzyme by glucagon was independent of the diet. In animals subjected to a controlled feeding regime, no circadian variation in the levels of urea cycle enzymes could be observed. However, the inducibility of the enzyme by glucagon was greatest if the hormone was given near the beginning of the period of darkness and feeding.

Aging↗
PubMed1978

Job satisfaction and perceived congruence of attitude between workers and supervisors in a mental health setting.

The Community Mental Health Ideology Scale and Minnesota Satisfaction Questionnaire were administered to the staff of an outpatient treatment facility. Perceived congruence of attitude and job satisfaction including working conditions, pay, agency policy, and other variables were examined. Congruence of attitude between worker and supervisor was positively related to satisfaction with supervisor and agency policy. There were differences among the various disciplinary groups with those workers who had the least education tending to be satisfied in more spheres than those with more education or advanced professional degrees.

Administrative Personnel↗
PubMed1977

The long-term follow-up of 195 patients with renal failure: a preliminary report.

Radiographic and bone mineral (BM) data were collected over a three-year period on 195 patients with chronic renal failure. Most women maintained BM on dyalysis, whereas 44% of the men lost BM (p less than 0.05). Following transplantation, 86% of the patients either maintained or restored BM. After parathyroidectomy, only half of the women and 34% of the men gained BM. Normal radiographs may be associated with low BM values, but there is a correlation between decreasing BM and increasing renal osteodystrophy in women (p less than 0.05).

Adult↗
PubMed1976

New approaches to the management of severe acute pancreatitis.

A recent experience with seventy-seven patients admitted to Boston City Hospital for acute pancreatitis permitted us to identify thirteen patients (17 per cent) whom we diagnosed as having severe protracted acute pancreatitis. These alcoholic patients obviously had fulminant pancreatitis similar to that reported by others in two instances and pancreatic abscesses in two additional instances, but nine of the patients did not fulfill the criteria usually used by others as a basic for surgical intervention. Specific preoperative diagnosis was obtained in these patients by the aggressive use of endoscopic cannulation of the pancreatic ducts, which documented the presence of surgically correctable lesions. These patients had sustained significant malnutrition, which was corrected only by protracted therapy extending an average of two months and involving all modalities currently available for nutritional support of the severely ill patient. After proper preoperative identification of a specific lesion and correction of the malnutrition, the eleven patients without fulminant disease were operated on with no deaths or significant complication. Nine of the patients had elective procedures, which included six distal pancreatectomies and one total pancreatectomy. Thus, severe protracted acute pancreatitis can be identified, and once categrorized, it can have therapeutic implications.

Acute Disease↗
PubMed1976

Accumulation of chlorporomazine by subcellular fractions of rat brain.

1. The study of the in vitro accumulation of [3H] chlorpromazine that a state of rapid equilibrium was reached for subcellular particles from cortex, midbrain and hindbrain of rats. 2. This accumulation was not saturable by increasing the concentration of chlorpromazine, and the relationship between accumulation and concentration was not modified by temperature, preincubation with high concentration of unlabelled chlorpromazine or by lowering the fraction concentration. 3. The highest accumulation of radioactivity was seen in the midbrain region and the lowest in the hindbrain. 4. In the cortex and midbrain the membrane fraction showed the highest accumulation. 5. The effect of pH on the accumulation indicated that a significnat rise was seen between pH 8 and 5. 6. This factor could also be explained in terms of solubility of the drug in membranes. 7. Studies on the metabolic fate of the drug during incubation indicated that there was a fairly rapid breakdown during incubation, the highest being seen with mitochondrail fractions and the least with membrane procedures. 9. It is concluded that accumulation of chlorpromazine by subcellular fractions in vitro may be associated with solubility in membranes and that the picture may be complicated by the presence of breakdown products.

Animals↗
PubMed1976

Near-fatal hemorrhage following gastrografin studies.

The use of upper gastrointestinal studies followed by gastric drainage and observation is recommended for the evaluation and treatment of stomal dysfunction due to edema or gastric atony. Gastrografin though, may be precipitated out and can cause gastrointestinal bleeding if left in the gastric remenant. This agent should be used with proper precautions in the evaluation of postoperative gastric retention.

Diatrizoate↗
PubMed1975

The community and medical education: organization and function of a board of concerned citizens.

A Board of Concerned Citizens was organized in 1971 to facilitate the resolution of problems between the College of Medicne and Dentistry of New Jersey at Newark and the community in which it is located. The board has provided an orderly imput by consumers, representatives of community organizations and nonfaculty employees into decisions on policies and programs of the medical and dental schools. It has aided in the resolution of employee grievances and student problems, given support needed to assist the development of quality health care services, helped improve the climate for clinical research, and served as an intermediary between the community and college on issues of special concern to local residents. An opinion poll conducted 3 1/2 years after its organization shows c ontinued support by citizenry, nonfaculty employees, faculty, and students for a Board of Concerned Citizens. Experiences of the board indicate that investigations and recommendations of a properly organized and motivated group of community residents and leaders can provide an effective bridge between a community and a medical or dental school.

Community Participation↗