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Biomedical subjects

E Philipp

Publications and source records attributed to E Philipp.

At least 19 recordsLinked to original sources
PubMed1990

[Oral complications in patients with anorexia nervosa and bulimia nervosa].

This article presents the oral situation of 11 anorectic and 41 bulimic patients and compares it with 50 healthy control persons. While patients with an eating disorder showed less signs of gingival inflammation (SBI: anorexia: 14.6%; bulimia: 12.5%; controls: 44.7%), they had clearly more enamel erosions than healthy control persons. In 27 of 41 bulimic patients a bilateral swelling of the parotid gland was found. A significant correlation between the parotid enlargement and enamel erosion exists in bulimic patients with an anorectic prephase. Patients with an eating disorder had higher levels of serum amylase than healthy control persons. A significant correlation between serum amylase activity and dental characteristics was found in bulimic patients.

Adult↗
PubMed1989

Sick doctors.

Explore the source record for details and available documents.

Humans↗
PubMed1987

Assay for tyrosine hydroxylase in hypothalamic homogenates using high-performance liquid chromatography with electrochemical detection.

A highly sensitive and reliable assay for tyrosine hydroxylase (TH) activity in hypothalamic homogenates of male rats using high-performance liquid chromatography with electrochemical detection is described. Modification of sample preparation and chromatographic conditions led to a complete separation of L-3,4-dihydroxyphenylalanine (L-DOPA) and alpha-methyldopa from all interfering catecholamines and their metabolites. This assay is highly sensitive; 2 pmol of L-DOPA formed enzymatically could be measured. We were able to determine TH activity in tissue pieces weighing less than 1 mg. TH activity was not changed after storage for three months at -80 degrees C. In hypothalamic homogenates the Michaelis constant (KM) for L-tyrosine was 80.5 +/- 6.5 mumol/l and the maximal velocity (Vmax) was 132.5 +/- 10.5 pmol/mg of protein per min for L-DOPA formed enzymatically.

Animals↗
PubMed1987

Effect of starvation on hypothalamic tyrosine hydroxylase activity in adult male rats.

The activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in norepinephrine synthesis, was determined in the mediobasal hypothalamus of adult male rats during acute and semistarvation. 3,4-Dihydroxyphenylalanine (DOPA) formed by TH was measured using high-performance liquid chromatography (HPLC). Acute starvation, as well as 3 weeks of semistarvation on a high-protein low-carbohydrate diet (CST PR) reduced TH activity significantly. Three weeks of a low-protein high-carbohydrate diet (CST KH) did not affect TH activity. While maximal velocity (Vmax) is significantly diminished in acute starvation and in semistarvation with a high-protein low-carbohydrate diet, Kd-values for tyrosine were not changed. These results suggest that TH activity in the brain contributes to decreased norepinephrine (NE) turnover in starvation.

Acute Disease↗
PubMed1987

Oral nafazatrom in man: effect on inhaled antigen challenge.

The effect of oral nafazatrom (Bay g6575, 2 X 3 g) or placebo on inhaled antigen challenge was assessed in a double-blind study. In four subjects antigen challenge resulted in an immediate fall of 93.2 +/- 3.36% in airflow at 40% of vital capacity (Vp40) and a 45.85 +/- 4.95% reduction in forced partial expiratory volume at one second (FEV1). Neither nafazatrom nor placebo had any effect on baseline lung function or that after challenge. Leukotriene B4 was generated by ex vivo stimulus of blood with ionophore A23187, and quantified by high performance liquid chromatography (h.p.l.c.)-radioimmunoassay. No inhibition of LTB4 formation occurred ex vivo following oral nafazatrom, although addition of 10(-5) M nafazatrom to blood in vitro significantly inhibited LTB4 release. Peak plasma nafazatrom levels during the study ranged from 3.3 X 10(-7) M to 1.47 X 10(-6) M which are below the concentration (10(-5) M) at which significant 5-lipoxygenase inhibition occurs in vitro. Oral nafazatrom is ineffective as a 5-lipoxygenase inhibitor in man, probably because of poor bioavailability after administration.

Adult↗
PubMed1986

A clinical trial of nafazatrom (Bay g 6575) in advanced cancer.

Nafazatrom (Bay g 6575) has been shown to be a potent inhibitor of tumor metastasis in preclinical models. It is believed to work by stimulating endogenous prostacyclin production. The drug has also been shown to inhibit the growth of certain experimental tumors, to be cytostatic for certain cell lines in tissue culture, and to induce differentiation in HL-60, neuroblastoma, and Friend erythroleukemia cell lines. Furthermore, no toxicity has been seen in animals or human volunteers. We report here a clinical trial of oral nafazatrom at five dose levels in patients with advanced cancer. Thirty patients with a wide variety of advanced malignancies were treated for 26-638+ days (median 82 days). No tumor responses were seen. Toxicity included two cases with mild skin rashes, one case with nausea and vomiting, and one case with diarrhea. Nafazatrom is a safe and well-tolerated agent. Maximum activity would be predicted to occur in the adjuvant treatment of cancer and we feel that further efforts should proceed to identify the appropriate dose for such a trial.

Adult↗
PubMed1986

Can children's paintings of their doctors be interpreted?

There is increased emphasis nowadays on the role of the general practitioner in preventive care for children. Accordingly, an analysis of the child's perception of the doctor and of the factors which influence and mould that perception are important. In New Zealand children's paintings have been used for such analyses. The present study looked at children's paintings of their family doctors in a Devonshire village. The findings show that boys are more likely than girls to depict their doctors as a gruesome or threatening character, and suggest that medical contact has little, if any, influence on character portrayal of doctors. Other factors that might influence character portrayal and are now thought worthy of detailed study, include television viewing patterns, personality, age, home background and artistic ability.

Art↗