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Biomedical subjects

E Otomo

Publications and source records attributed to E Otomo.

At least 73 records · Page 4Linked to original sources
PubMed1989

[CT study in senile dementia of Alzheimer type].

In order to evaluated the utility of cranial CT in diagnosis of senile dementia of Alzheimer type (SDAT) various CT findings were studied. CT scans of 62 cases with SDAT (83 +/- 6 years old) were compared with those of 357 aged cases (means 78 +/- 8 years old) with out psychiatric and/or neurological illness (normal control NC). The methods of evaluating CT findings were linear measurements of the ventricle (Huckman number, Evans' ratio, lateral body ratio), observation of sulci (Sylvian fissure, cingulate sulcus and central sulcus), brain atrophy ranking of microscopic observation (I; absent, II; mild, III; mild to moderate, IV; moderate, V; maximum) and presence of periventricular lucency. When SDAT were compared with NC the cases were divided into two groups by the age (the eighth decade, 80 years old and over) in order to avoid the influence of physiological brain atrophy. The results were as follows: 1) In SDAT there was a positive correlation between the volume of the lateral ventricle in autopsy brain and each index which demonstrates the size of the lateral ventricle on CT (r = 0.65, p less than 0.001). 2) In SDAT the incidence of cases with more than III degree in brain atrophy ranking was significantly higher than in NC (p less than 0.001). It was 82.6% in SDAT, 15.7% in NC in the eighth decade and 92.3% in SDAT, 32.1% in NC in 80 years and over. 3) The mean values of indexes of lateral ventricle enlargement (Huckman number, Evans' ratio, lateral body ratio) in SDAT increased more than those in NC significantly (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1988

Systemic amyloid deposition in old age and dementia of Alzheimer type: the relationship of brain amyloid to other amyloid.

We investigated amyloid deposition in the brain and other organs in 105 consecutive autopsy cases, aged 59 to 101 years. They consisted of two groups; 15 patients with dementia of Alzheimer type (DAT) and 90 patients without DAT. Amyloid deposition was found in 93% of all cases. The incidence of amyloid deposition increased with age. The number of organs affected with amyloid deposition in each case also increased with age. The incidence of amyloid deposition in each organ was as follows; 88% in pituitary gland, 66% in brain [amyloid of senile plaque (SP) (61%) and/or cerebral amyloid angiopathy (CAA) (56%)], 33% in pancreas, 3% in heart, and less in others. In immunohistochemical studies using the antisera to the various kinds of amyloid or related proteins, amyloid beta protein was demonstrated in brain amyloids including SP and CAA, but not in others. Cardiac amyloid was positive for prealbumin. Pituitary amyloid and CAA were positive for amyloid P-component. The incidence of brain amyloids in DAT were significantly higher than that in non-DAT. There was no significant difference in the incidence of pituitary and pancreatic amyloid between DAT and non-DAT. In the non-DAT patients, there were significant positive correlations in amyloid deposition between the brain and pituitary gland and between the brain and pancreas. Acceleration of amyloid deposition would be a process confined to the brain in the patients with DAT. The pathogenesis of the accelerated deposition of brain amyloids is discussed from the point of view of amyloidosis.

Aged↗
PubMed1988

Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebo-controlled study.

A multicenter double-blind placebo-controlled study of cytidine 5'-diphosphocholine (CDP-choline) was conducted to evaluate possible clinical benefits of the drug in patients with acute, moderate to severe cerebral infarction. The patients included also suffered from moderate to mild disturbances of consciousness, and all were admitted within 14 days of the ictus. Patients were allocated randomly to treatment with either CDP-choline (1,000 mg/day i.v. once daily for 14 days) or with placebo (physiological saline). One hundred thirty-three patients received CDP-choline treatment, and 139 received placebo. The group treated with CDP-choline showed significant improvements in level of consciousness compared with the placebo-treated group, and CDP-choline was an entirely safe treatment.

Acute Disease↗
PubMed1987

Cerebral amyloid angiopathy in the aged.

Cerebral amyloid angiopathy (CAA) was found in 57% of 123 autopsy brains removed from patients aged 59-101 years. The incidence of CAA increased with age. CAA was seen most frequently in the occipital cortex. Immunohistochemically, amyloid of CAA was positive for amyloid P component and negative for human AA protein and human prealbumin. The presence and severity of CAA were significantly correlated with the number of senile plaques and neurofibrillary tangles. The incidence of CAA in 17 patients with dementia of Alzheimer type (DAT) was estimated to be 88% and was significantly higher than that in 26 patients with dementia of non-Alzheimer type. CAA had a pathogenetic relationship with both brain ageing and DAT. Lobar cerebral haemorrhage was found in 3 patients with CAA of marked or moderate degree. Lobar cerebral haemorrhage in the aged and in patients with DAT suggest the presence of CAA.

Aged↗