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Biomedical subjects

E Normann

Publications and source records attributed to E Normann.

35 records · Page 2Linked to original sources
PubMed1978

Clinical results with 131I-toluidine blue and triple radionuclide subtraction for preoperative localization of enlarged parathyroid glands.

Clinical results from the application of a triple radionuclide subtraction study for preoperative localization of enlarged parathyroid glands are presented in this paper. A scintillation camera image was recorded after i.v. injection of 131I-toluidine blue. The contributions to this image from activity in the thyroid gland and in blood were determined after recording of additional images (obtained after injection of 99mTcO4- and 113mIn, respectively) using an iterative computer algorithm that also provides an estimate for a uniform background. Subtraction of these contributions gives an image that may be interpreted as an image of the selective accumulation of 131I-toluidine blue in the parathyroids. One or more enlarged glands were correctly localized in 17 of 21 cases, but in four cases there were only false positives. In ten cases the correctly localized glands weighed 900 mg or less.

Adult↗
PubMed1977

Secretion of calcitonin and gastrin in rats with transplanted medullary thyroid carcinoma.

Rats transplanted with medullary thyroid carcinoma (MCT) were followed with radio-immuno assay of serum calcitonin (iCT) using antisera to human CT and I125 labelled calcitonin-M. From the 4th month after transplantation, serum from the tumour rats contained iCT in concentrations 8-10 fold higher than serum from the control rats. The tumour cells had retained their ability to react on pentagastrin and calcium injections with increased CT release. It was further shown that the tumour bearing rats had elevated basal gastrin concentratkons in serum. While calcium injection lead to a rise in the serum gastrin concentration in the control group, the adverse effect was seen in the tumour bearing rats. The morphological features and the responsiveness of the rat tumour cells to physiological secretagogues make this tumour a suitable animal model for the study of interactions between CT and gastro-intestinal factors. It is suggested that the gastrin response to calcium might be of interest also in the diagnosis of human MCT.

Animals↗
PubMed1976

Pindolol (Viscén) in persistent ventricular fibrillation. A case report.

The beneficial effect of a beta-blocking agent (pindolol), given as an adjuvant to DC-shock and lidocaine therapy in a case of heart resuscitation is reported. A 65-year-old female patient was operated for an abdominal aortic aneurysm. At the conclusion of the operation, which was prolonged and difficult, the patient developed alternating ventricular tachycardia and fibrillation. Within a time interval of 50 min electrical defibrillation was performed 20 to 25 times, and as much as 1100 mg of lidocaine was administered. Simultaneously, combined internal/external cardiac massage was performed. The patient's arrhythmia continued to recur after defibrillation until pindolol in dosages of 0.2 mg had been given twice intravenously. A permanent sinus rhythm was then achieved.

Aged↗
PubMed1976

Use of 131I-toluidine blue in radionuclide imaging of enlarged parathyroid glands.

Parathyroid scintigraphy with 131I-labelled toluidine blue was performed in 40 patients, 30 of whom were operated for suspected hyperparathyroidism. Hyperplastic glands or adenomas could be localized by scintigraphy in 18 of 27 patients who proved to have hyperparathyroidism. The correlation between scintigraphy and operative finding was always correct when the parathyroids weighed more than 2 g. Scintigraphy was correctly negative in one, falsely negative in 6, and falsely positive in 5 of the operated patients. In a group of 10 unoperated patients, scintigraphy was positive in one of the 3 patients with suspected hyperparathyroidism, but negative in the others. Although 131I-toluidine blue is not ideal as a scintigraphic agent for the parathyroids, we are of the opinion that it represents an improvement compared with 75Se-selenomethionine.

Evaluation Studies as Topic↗
PubMed1975

Perforated appendicitis--lavage or drainage?

A comparison was made regarding the observed frequency of intraperitoneal complications between two groups of patients operated upon for perforated appendicitis during a 5-year period (1968-73). The two groups, corresponding to two different general surgical departments at the same hospital, were given different forms of adjuvant treatment. The first group (78 patients) received postoperative intraperitoneal lavage, with antibiotics added to the lavage solution. In the other department (77 patients), the peritoneal cavity was drained postoperatively. No lavage was performed in this group, but antibiotics were given systemically. Sixteen patients in the drainage group developed intraperitoneal complications, as compared with 5 in the lavage group.

Adolescent↗
PubMed1975

Doxycycline levels in prostatic tissue and blood.

Doxycycline was administered orally to 23 patients scheduled for prostatectomy or radical cystectomy. Blood and prostatic tissue samples were collected simultaneously during operation and subsequently assayed for doxycycline levels. The concentration of doxycycline in the prostatic tissue was on average 2.75 mug/g which is far above the therapeutic level. The lowest level recorded was 0.85 mug and the highest was 4.81 mug. The findings suggest a tendency for this antibiotic to accumulate in prostatic tissue. This is in agreement with the clinical observations of the good effect of doxycycline treatment in patients with chronic bacterial prostatitis.

Administration, Oral↗