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Biomedical subjects

E Normann

Publications and source records attributed to E Normann.

At least 19 recordsLinked to original sources
PubMed2006

Association between Chlamydia pneumoniae antibodies and wheezing in young children and the influence of sex.

BACKGROUND: The proposed association between Chlamydia pneumoniae (Cpn) infection and wheezing needs further clarification. METHODS: Serum samples obtained from 1581 children aged 4 years in a population based cohort were tested for antibodies to Cpn and IgE antibodies to common allergens. Data on environmental factors and disease were collected prospectively from birth. RESULTS: The occurrence of IgG antibodies to Cpn at 4 years of age was associated with reported wheezing at different ages; however, these findings were most often not significant. In girls, the occurrence of anti-Cpn IgG was associated with wheezing at the ages of 1, 2, and 4 years (odds ratios (ORs) 3.41 (95% confidence interval (CI) 1.46 to 7.96), 2.13 (95% CI 1.02 to 4.44), and 2.01 (95% CI 1.14 to 3.54), respectively), and even higher ORs were observed for each age category when only high level antibody responses to Cpn were analysed. At the time of blood sampling the association between anti-Cpn IgG and wheezing was restricted to girls without atopic sensitisation (OR 2.39 (95% CI 1.25 to 4.57). No associations with wheezing were detected in boys, in whom IgE sensitisation was inversely associated with the presence of anti-Cpn IgG (OR 0.49 (95% CI 0.26 to 0.90)). CONCLUSIONS: This study suggests an association between evidence of earlier Cpn infection and a history of wheezing in young girls. Infection with Cpn may be an important risk factor for wheezing and possibly for non-atopic asthma, predominantly in girls.

Antibodies, Bacterial↗
PubMed2003

Regional cerebral blood flow in patients with primary hyperparathyroidism before and after successful parathyroidectomy.

BACKGROUND: Single-photon emission computed tomography (SPECT) is used to study cerebral blood flow and cerebral metabolism in various neuropsychiatric disorders. Reduced regional cerebral blood flow has been demonstrated in patients with depression and chronic fatigue, symptoms that are common in primary hyperparathyroidism. The aim of this study was to reveal possible changes in regional cerebral blood flow in patients with primary hyperparathyroidism before and after operative treatment. METHODS: This was a prospective study of regional cerebral blood flow in 16 consecutive women of median age 72 (range 50-82) years using SPECT with (99m)Tc-labelled hexamethylpropylenamine-oxime. The measurements were performed before and 2, 4 and 12 months after parathyroidectomy. The Montgomery and Asberg depression rating scale (MADRS) depression score was used as a parallel clinical test. RESULTS: Reduced (pathological) regional cerebral blood flow was seen before operation in 14 patients, 13 with a solitary adenoma and one with double adenoma. After surgery, this improved to normal values in 13, but was further reduced in one. In two patients with preoperative normal regional cerebral blood flow, both of whom were asymptomatic and had diffuse hyperplasia, a slight reduction was demonstrated. Eight patients had a pathological preoperative MADRS score, which normalized in seven after surgical treatment. CONCLUSION: The finding of reduced regional cerebral blood flow in patients with primary hyperparathyroidism followed by significant improvement after operation might influence the case for surgical treatment.

Aged↗
PubMed2001

[Lithium treatment and hyperparathyroidism].

BACKGROUND: Lithium treatment, which is extensively used in bipolar affective disorders, may give rise to hypercalcaemia and sometimes to irreversible hyperparathyroidism. MATERIAL AND METHODS: We present a patient who developed hyperparathyroidism following long-term treatment with lithium. RESULTS: After 15 years on lithium the patient was diagnosed with hypercalcaemia; at the same time the patient stopped her lithium medication. Two years later she developed depression with psychotic symptoms and was given electroconvulsive treatment. Measurements of serum calcium and parathormon showed that she had developed hyperparathyroidism. Neck exploration was performed, and two parathyroid adenomas (weight 650 mg and 880 mg), which had been detected by scintigraphy, were removed. Lithium treatment was restarted. One year later she was normocalcaemic and her mood was normal. INTERPRETATION: In lithium-induced hyperparamyroidism, lithium should be replaced with other mood stabilizers, preferably an antiepilepticum. If cessation of lithium therapy does not lead to normocalcaemia, parathyroidectomy is indicated.

Antidepressive Agents↗
PubMed2001

Chlamydia pneumoniae in children undergoing adenoidectomy.

UNLABELLED: Chlamydia pneumoniae is a common respiratory pathogen which is often found in paediatric populations. Little is known about the true colonization rate and the localization of the bacteria in the respiratory tract. In this study, immunohistochemistry was used to examine adenoids from 69 children undergoing elective adenoidectomy. Throat swabs for polymerase chain reaction (PCR) and blood samples for serology were also obtained. Chlamydia pneumoniae was demonstrated in the adenoids by immunohistochemistry in 68 of the children. Five children (7%) had a positive C. pneumoniae PCR test from throat swabs and 14 children (20%) had detectable antibodies by the microimmunofluorescence technique. CONCLUSION: The results suggest that C. pneumoniae is a common finding in the adenoids of children undergoing adenoidectomy. Whether or not C. pneumoniae plays a pathogenic role in this patient population could not be determined from the data obtained in this investigation.

Adenoidectomy↗
PubMed2000

[Primary hyperparathyroidism--a 16-year material from a central hospital].

BACKGROUND: In Norway, population 4.3 million, approximately 160 patients a year have undergone surgery for primary hyperparathyroidism during the last ten years. Previous reports are rare. MATERIAL AND METHODS: A retrospective analysis of all patients operated for primary hyperparathyroidism during 16 years at Vestfold Hospital, which serves a population of 200,000. Late recurrences and persisting hypocalcaemia were evaluated with laboratory tests median eight years after surgery. RESULTS: 104 patients were operated (88 females and 16 males; median age 64 years, range 22-78). Adenomas were found in 88 patients, of which four had double adenomas, and hyperplasia in 16 patients. Three patients died postoperatively, within 30 days, all of them high-risk patients. Two patients were reoperated because of bleeding. In one patient an infection was drained. Median hospital stay was five days. Two patients had persisting hypercalcaemia; eight patients needed permanent vitamin D substitution. Four recurrences were detected. Normocalcaemia was achieved in 91 patients (90%). INTERPRETATION: Surgical treatment leads to normocalcemia in 90% of patient, but is not risk-free in severely ill patients. To assess the true benefit of the operation for the individual patient, better preoperative mapping of symptoms and better follow-up protocols should be implemented.

Adult↗
PubMed2000

Severe pancreatitis after parathyroidectomy.

Cope showed in 1957 that pancreatitis may be the presenting symptom in hyperparathyroidism. Since then, the literature has reported a coincidence of primary hyperparathyroidism and pancreatitis between 1% and 19%, but the true relationship has not been fully established. When severe pancreatitis follows parathyroidectomy, a condition familiar to parathyroid surgeons, reports are mostly anecdotal and by many authors considered to be coincidental. We present the case history of a 58-year-old man with a longstanding history of untreated primary hyperparathyroidism who developed severe pancreatitis immediately after removal of a 400-mg parathyroid adenoma. He was the first in a series of 108 operated patients to develop this complication. His preoperative levels of parathormone and serum calcium were the highest in our material. We believe that pancreatitis after parathyroidectomy is a real but rare complication that might be predicted by preoperative high values of serum calcium and parathormone.

Adenoma↗
PubMed1999

Vaginal disinfection with chlorhexidine during childbirth.

The purpose of this study was to determine whether chlorhexidine vaginal douching, applied by a squeeze bottle intra partum, reduced mother-to-child transmission of vaginal microorganisms including Streptococcus agalactiae (streptococcus serogroup B = GBS) and hence infectious morbidity in both mother and child. A prospective controlled study was conducted on pairs of mothers and their offspring. During the first 4 months (reference phase), the vaginal flora of women in labour was recorded and the newborns monitored. During the next 5 months (intervention phase), a trial of randomized, blinded placebo controlled douching with either 0.2% chlorhexidine or sterile saline was performed on 1130 women in vaginal labour. During childbirth, bacteria were isolated from 78% of the women. Vertical transmission of microbes occurred in 43% of the reference deliveries. In the double blind study, vaginal douching with chlorhexidine significantly reduced the vertical transmission rate from 35% (saline) to 18% (chlorhexidine), (P < 0.000 1, 95% confidence interval 0.12-0.22). The lower rate of bacteria isolated from the latter group was accompanied by a significantly reduced early infectious morbidity in the neonates (P < 0.05, 95% confidence interval 0.00-0.06). This finding was particularly pronounced in Str. agalactiae infections (P < 0.0 1). In the early postpartum period, fever in the mothers was significantly lower in the patients offered vaginal disinfection, a reduction from 7.2% in those douched using saline compared with 3.3% in those disinfected using chlorhexidine (P < 0.05, 95% confidence interval 0.01-0.06). A parallel lower occurrence of urinary tract infections was also observed, 6.2% in the saline group as compared with 3.4% in the chlorhexidine group (P < 0.01, 95% confidence p interval 0.00-0.05). This prospective controlled trial demonstrated that vaginal douching with 0.2% chlorhexidine during labour can significantly reduce both maternal and early neonatal infectious morbidity. The squeeze bottle procedure was simple, quick, and well tolerated. The beneficial effect may be ascribed both to mechanical cleansing by liquid flow and to the disinfective action of chlorhexidine.

Adult↗
PubMed1998

Chlamydia pneumoniae in children with acute respiratory tract infections.

Children seeking medical attention for acute respiratory tract infections were investigated for evidence of Chlamydia pneumoniae infection. Blood samples were obtained from 367 children. Nasopharyngeal or throat swabs for PCR analysis (polymerase chain reaction) were taken from 360 children. Serology was found to be useful for diagnosis of infection only in children aged > 5 y. Using PCR, a prevalence of 8 and 10% of C. pneumoniae was found in male and female children aged < 2 y; 17 and 19%, respectively, in the age group 2-4 y and 32 and 21%, respectively, in the age group 5-16 y. We conclude that Chlamydia pneumoniae is a common finding in young children with respiratory tract infections. Younger children were more often found to have a moderate disease, but may have been ill for a long period.

Acute Disease↗
PubMed1998

Chlamydia pneumoniae in children attending day-care centers in Gävle, Sweden.

BACKGROUND: The epidemiology of Chlamydia pneumoniae in healthy children has not been established. METHODS: This investigation used polymerase chain reaction (PCR) to study the epidemiology of C. pneumoniae in presumed healthy children. Four hundred fifty-three children and 142 personnel at 9 day-care centers were investigated for carriage of C. pneumoniae. Children found to be positive by PCR were also investigated with serology, and their family members were tested with PCR. RESULTS: One hundred and three (22.7%) children had a positive PCR, as had 33 (23.2%) personnel. Fourteen percent of the children younger than 3 years had a positive PCR test compared with 26% of the older children (P < 0.01). No correlation was found between respiratory symptoms and carriage of C. pneumoniae. Mothers were more often positive in the PCR test as compared with fathers (relative risk, 2.59; 95% confidence interval, 1.16 to 5.78). Antibodies to C. pneumoniae were found in 27 of 97 PCR-positive children; only 2 of whom were younger than 3 years. CONCLUSION: C. pneumoniae can be commonly found in young children attending day care. Most of the youngest children did not develop specific antibodies. Children may have subclinical infections with C. pneumoniae. The organism seems to be easily communicable among individuals living in close proximity.

Carrier State↗
PubMed1981

Bilateral primary bronchial carcinoma.

Three cases of bilateral primary bronchogenic carcinomas, one simultaneous and two consecutive, were encountered among 1033 patients treated for primary lung malignancies. Consecutive bilateral surgical resections were performed in two instances. The third case underwent irradiation therapy alone. The risk of developing a second primary bronchogenic carcinoma increases during survival time. Therefore, all patients successfully treated for lung cancer should have lifetime follow-up examinations.

Aged↗
PubMed1980

Stones in renal transplants.

In a 50-year-old man (case 1) and a 17-year-old girl (case 2) stones developed in a functioning renal transplant. The respective intervals from transplantation to appearance of stone were seven years and six months. The serum calcium was elevated to approximately 3.00 mmol/l in case 1 and 2.65 mmol/l in case 2. The concentration of parathyroid hormone in serum was increased in case 1. Subtotal parathyroidectomy was performed in both patients, with removal of 2550 mg (case 1) and 150-160 mg (case 2) parathyroid tissue. In case 2 slight hypercalcaemia reappeared two months later. When stones in a transplanted kidney are associated with only slight hypercalcaemia and there is no deterioration of the renal function, conservative measures to reduce the serum calcium should be tried before subtotal parathyroidectomy is undertaken.

Adolescent↗
PubMed1979

Dose dependent uptake of 125I-toluidine blue of 75Se-selenomethionine in the parathyroids of rabbits.

Different dosages of 125I-toluidine blue and 75Se-selenomethionine were injected intravenously into rabbits, and the concentration of radioactivity was measured in the parathyroids and surrounding tissues. The response of i.v. injected glucagon was also determined. It was found that 0.16 mg 125I-toluidine blue gave a concentration ratio of parathyroid/thyroid and parathyroid/muscle which was significantly higher than both lower and higher doses at 1 minute after i.v. injection of the labelled dye. Glucagon had little or no effect on the uptake of 125I-toluidine blue and 75Se-selenomethionine.

Animals↗
PubMed1979

Skin necrosis between parallel abdominal incisions.

Four cases of skin necrosis between vertical abdominal incisions are presented. Even though many years may elapse between the abdominal operations, necrosis of the skin as well as of the underlying fascia may develop between new and old vertical incisions parallel with each other. Such necrosis probably takes place particularly in patients with impaired peripheral circulation.

Abdominal Muscles↗
PubMed1979

Necrosis of the colon and the rectum after resection of ruptured abdominal aortic aneurysm.

Two male patients with gangrene of the rectum and left colon following operation for a ruptured abdominal aortic aneurysm are reported. Both patients were in shock over a prolonged period, but ligation of the inferior mesenteric artery in the presence of insufficient collateral circulation to the large bowel was regarded as the main responsible factor for the visceral infarction. Both patients died postoperatively. The anatomical and pathophysiological factors generally involved in the development of colon ischaemia after abdominal aortic aneurysm surgery are analyzed. The different modalities of prevention of colon necrosis, diagnosis and management of the established lesions are described.

Aged↗