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Biomedical subjects

E Morris

Publications and source records attributed to E Morris.

At least 127 records · Page 7Linked to original sources
PubMed1979

Management of toxic megacolon: the significance of early recognition in medical management.

Twenty-seven patients with acute toxic dilatation of the colon (TM) as a complication of inflammatory disease of the colon are reported. To emphasize the importance of early recognition and therapy, we separated the patients into two groups: 19 were receiving care by the authors (series A) before the development of TM, and eight were seen in consultation after its onset (series B), TM subsided with medical therapy in 13 episodes among 19 patients in series A and two of eight B. The others underwent surgical therapy. There were no deaths in either group. The differences in management and mortality from other reports suggest a program of surveillance and therapy for this life-threatening situation.

Adolescent↗
PubMedDate not supplied

Three-Dimensional Reconstruction of a Collagen IV Analogue in the Dogfish Egg Case Wall.

The wall of the egg case of the dogfish (Scyliorhinus canicula) contains an analogue of collagen Types IV and VIII organised into a regular 3-dimensional network. It presumably provides both a protective and a filtering role for the eggs contained within it. Electron micrographs of longitudinal and transverse sections, including systematically tilted sections, have been used both to define, for the first time, the space group symmetry of the lattice and to carry out 3-D reconstruction of the unit cell contents. This cell was found to be tetragonal, space group I422, with a = b = 11 ± 1 nm, and c = 74 ± 4 nm. Consistent with this, projection symmetries were c2mm for the [1,0,0] view, p2mm for the [1,1,0] view, and p4mm for the projection down the c axis (the [0,0,1] view), and all observed reflections in the computed Fourier transform obeyed the rule h + k + l = 2n (n integer) for body-centred lattices. The 3-D reconstruction, the first electron micrograph 3-D reconstruction of a collagen-containing material, is interpreted in terms of variations of previous molecular models for this structure. Type IV collagen is a constituent of the basal lamina, where it forms a network with both structural and filtering properties. The dogfish egg case structure may throw light on the (less regular) collagen IV structure of the basal lamina.

Journal Article↗
PubMedDate not supplied

Structure and nucleotide-dependent changes of thick filaments in relaxed and rigor plaice fin muscle.

The myosin crossbridge array, positions of non-crossbridge densities on the backbone, and the A-band "end filaments" have been compared in chemically skinned, unfixed, uncryoprotected relaxed, and rigor plaice fin muscles using the freeze-fracture, deep-etch, rotary-shadowing technique. The images provide a direct demonstration of the helical packing of the myosin heads in situ in relaxed muscle and show rearrangements of the myosin heads, and possibly of other myosin filament proteins, when the heads lose ATP on going into rigor. In the H-zone these changes are consistent with crossbridge changes previously shown by others using freeze-substitution. In addition, new evidence is presented of protein rearrangements in the M-region (bare zone), associated with the transition from the relaxed to the rigor state, including a 27-nm increase in the apparent width of the M-region. This is interpreted as being mostly due to loss or rearrangement of a nonmyosin (M9) protein component at the M-region edge. The structure and titin periodicity of the end-filaments are described, as are suggestions of titin structure on the myosin filament backbone.

Adenosine Triphosphate↗