Search PubMed⌕ Search

Biomedical subjects

E Mendoza

Publications and source records attributed to E Mendoza.

50 records · Page 3Linked to original sources
PubMed1980

Furosemide intravenous infusion in normal man: electrolytic, metabolic and hormonal effects. Lack of changes in basal insulin and glucagon plasma levels.

Eight overnight fasted healthy young volunteers received an intravenous infusion of 0.5 mg furosemide per kg body weight administered in 60 min. This period was preceded and followed by two control periods of one hour each during which physiological saline (o.154 mol/l) was administered at a rate of 1 ml/min. Furosemide markedly increased the diuresis and natriuresis which reached 1260 +/- 198 ml and 138.4 +/- 20.9 mmol per hour respectively. This was associated with a significant three fold increase in urinary total catecholamines excretion. Blood glucose, plasma free fatty acids, insulin and glucagon concentrations did not exhibit any significant change during and after furosemide infusion, compared to pre-infusion values. These results demonstrate that, in normal man, doses of furosemide capable of exerting plasma concentrations. It is concluded that the stimulation of insulin and glucagon secretion observed in vitro with high furosemide concentrations (5 mmol/l) are not observed under usual therapeutic conditions.

Adult↗
PubMed1978

Sustained insulin-induced remissions of juvenile diabetes by means of an external artificial pancreas.

Remission of diabetes was attempted in 12 recent acute onset ketosis-prone juvenile diabetes after short term (5 +/- 1 days) but excellent blood glucose control by the external artificial beta-cell. The comparison group comrised patients undergoing traditional treatment (n = 28). Nine (75%) persistent (over 3-14 months of duration) although partial (oral drugs required) remissions were obtained in the former group as compared to 3 (11%) in the latter group (p less than 0.05). Cases which showed remissions after insulin infusion had a plasma insulin response to IV glucagon still present before insulin infusion, and a daily urinary C-peptide excretion significantly enhanced after (p less than 0.01). Urinary C-peptide/blood glucose remained improved during the remission period. Thus, early effective treatment by means of the artificial pancreas may break the vicious circle hyperglycaemia-insulin depletion-hyperglycaemia and lead to frequent and sustained remissions of juvenile diabetes.

Acute Disease↗
PubMedDate not supplied

Acoustic and perceptual indicators of normal and pathological voice.

The aim of this study was to obtain acoustic correlates to vocal quality of a group of men and women with and without voice disorders, based on evaluations of a group of judges experienced in the field of vocal rehabilitation. In male subjects, perceptual evaluation of normal, hoarse and rough voice qualities was related to the following acoustic features: frequency perturbation measures (JITA, RAP, and SPPQ), amplitude perturbation (SAPQ and VAM), soft phonation index (SPI) and fundamental frequency tremor intensity (FTRI). While these measures presented normal values for normal voice, hoarseness showed some deviations in perturbation frequency variables and very high SPI values, while rough voice showed deviations in all the measures. Qualities of female voices were perceived as normal, breathy and hoarse, but the acoustic correlates of these qualities were less conclusive.

Adult↗
PubMedDate not supplied

[Concordance between body self-perception and BMI estimated in a population of volunteers recruited on the IV National Day of Obese People].

OBJECTIVES: To assess the concordance between corporal self-perception and BMI calculated in a population of volunteers. SECONDARY OBJECTIVES: to know the percentage of overweight, normoweight and obese individuals in this population. SUBJECTS: The study includes 160 volunteers recruited at the Gómez Ulla and Severo Ochoa Hospitals in Madrid during the 4th edition of the "Obesity Day". ACTIONS: A total of 160 interviews were carried out, comprising a first group of 10 questions about how obesity is understood, how they classify themselves by self-perception (obese, overweight or normoweight individuals), the incidence of obesity in the family, living habits and the number of previous failed attempts to lose weight. In the case of a positive response to the last question, the survey is extended to 19 questions, analyzing the reasons, prescriptors, methods used, and weight loss results obtained. RESULTS: The mean Body Mass Index (BMI) of the interviewees was 26.2 +/- 4.97 kg/m2, with 27.45 +/- 5.4 kg/m2 for males and 25.76 +/- 4.7 kg/m2 for women. Overweight men represented 32.5%, with 27.3% overweight women, while obese men accounted for 25.6% and obese women amounted to 20.6%. The differences were not significant between sexes, normoweight, overweight and obesity groups. The concordance between self-perception and BMI using the kappa index was 0,464 for the total sample, 0.229 for males and 0.527 for women, and according to the valuation scale proposed by Landis and Koch, it would correspond to a moderate degree of agreement for the population in general, medium for men and moderate for women. CONCLUSIONS: Overweight and obesity affect a high percentage of the Spanish population (almost 50%). Women show greater concern about being overweight, are more likely to participate in prevention campaigns, and present a corporal perception more in line with their true weight. Preventive campaigns should be implemented to reach the male population better, taking into account that this population presents a greater cardiovascular risk. It is important to place the problem of obesity in the right terms, without any "obesophobia" leading to disorders of the eating behaviour, while indicating the importance of the risk attributable to obesity and excess weight.

Adult↗
PubMedDate not supplied

[Remission of diabetes during conventional insulin therapy or therapy controlled by use of an artificial pancreas].

12 recent acute-onset ketotic juvenile diabetics were optimally treated during 5 +/- days by means of an external artificial pancreas. Remission of diabetes occurred in 9 patients (75%). In a comparative group of 28 patients treated by conventional subcutaneous insulin, only 3 (11%) steady remissions were obtained. In a third group of 6 patients treated by insulin infusion without feed-back control, only 1 remission (17%) was obtained. The difference between these two groups and the first group (patients treated by the artificial pancreas) is significant (p less than 0.01). Urinary C-peptide/blood glucose ratio showed a steady improvement of insulin secretion during the remission period. At this time, actuarial analysis shows that the number of patients still in remission decreases during the first 10 months but seems to stabilize after this period. Duration of our remissions is equal to the duration of the "spontaneous" remissions taken from the literature. New treatment able to sustain the residual insulinsecretion during the remission phase (with presently can be induced frequently with our technique) are still to be found.

Adolescent↗
PubMedDate not supplied

[Complications of chickenpox].

A patient with typical varicella (chickenpox) developed several complications: nephrotic syndrome following glomerulonephritis, trombocytopenic purpura, gastrointestinal bleeding, disseminated intravascular coagulation, encephalitis and bronchopneumonia. The course was satisfactory having been given antibiotics, heparin and peritoneal dialysis. Recovery was 100%.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Cloverleaf cranial anomaly. Report of 2 cases].

Two cases of cloverleaf anomaly are presented. The first one was associated to complete spina bifida and flexion of elbows and knees, and the second to syndactyly of 3rd and 4th fingers of both hands; short, broad and swerved thumbs; rudimentary bilateral preaxial polydactyly, pes varus with broad first metatarsus. Authors agree with the opinion that this anomaly is a sign which may occur in disorders with early craniosynostosis and emphasise the importance of the identification of the underlying disorder because, knowing its pattern of inheritance, a proper genetic advice may be rendered. The neurosurgical procedure can be useful for cosmetic purposes and for encephalitic decompression, but the results are somewhat unsatisfactory because of the severity of the defect.

Abnormalities, Multiple↗
PubMedDate not supplied

[Electrocardiographic evaluation of the cardiotoxicity of N-methylglucamine antimonate (R glucantime)].

The heart toxicity of N-Methyl-glucamine antimoniate (R glucantime) was studied by electrocardiographic readings in 16 patients with acute cutaneous Leishmaniasis. All patients studied came from the town of Tovar and it's surrounding areas, in the district of Tovar, Merida State, Venezuela. A dosage of 25 to 50 mg/kg/day of N-Methyl-glucamine in two or three treatment series, produced the healing of the cutaneous sore, without electrocardiographic alterations which could be interpreted as signs of myocardial toxicity.

Adolescent↗