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Biomedical subjects

E Mendoza

Publications and source records attributed to E Mendoza.

At least 37 records · Page 2Linked to original sources
PubMed1996

[Presence in Cuba of screw worms (Cochliomyia hominivorax) in the livestock].

Screw-worms (Cochliomyia hominivorax Coquerel) constitute a serious plight for livestock in the New World, because they inflict high losses on animals and man. A survey was done by means of an epizootic surveillance system with geographic squares to check for the presence of the insects in Cuba. Screw-worms were detected in 54.8% of myiasis cases all over the island, affecting various animals species, cattle first, followed by swine, sheep and others. Small injuries appeared to be the main enabling factor for screw-worm development. The reasons for the presence of screw-worms without serious consequences on the Cuban livestock are discussed.

Animals↗
PubMed1995

[A cystic lymphoepithelial lesion of the parotid in HIV-1-infected patients].

Cystic lymphoepithelial lesion is an infrequent disorder involving the saliva glands mainly the parotid gland; however, its frequency has increased coinciding with the epidemics of HIV-1 infection. Three cases of parotid lymphoepithelial lesion in patients with HIV-1 infection, 2 of whom were hemophiliacs and one an ex-intravenous drug addict, are presented. In all the cases the lesion was a painless slow growth right submandibular mass, with no history of inflammation. Two of the patients had a contralateral tumor of the same characteristics which was not studied. Fine needle aspiration puncture was performed in the three patients although diagnosis was obtained by pathologic study following superficial parotidectomy. Cystic lymphoepithelial lesion is an entity to be taken into account on differential diagnosis of cervical masses in patients with HIV infection. In individuals with severe immunosuppression treatment should be conservative.

Acute Disease↗
PubMed1995

Tropheryma whippelii endocarditis confirmed by polymerase chain reaction.

This report concerns a patient with cardiac manifestation of Whipple's disease. For the first time, the gene that encodes the 16s rRNA of Tropheryma whippelii was identified in a native aortic valve by means of a polymerase chain reaction technique. DNA amplification gives evidence of Tropheryma whippelii as a causative organism in infective endocarditis.

Actinobacteria↗
PubMed1995

Allogeneic bone marrow transplantation for Hodgkin's and non-Hodgkin's lymphoma.

We studied 23 consecutive patients, median age 34 years, with relapsed or resistant aggressive lymphoma who underwent allogeneic BMT at the UCLA Medical Center Bone Marrow Transplantation Unit from 1 November 1984 to 30 March 1993. All patients were < 50 years of age and had sibling donors who were matched at the HLA-A, B and DR loci. Nine patients had Hodgkin's disease (HD) and 14 had non-Hodgkin's lymphoma (NHL); three of these had low grade histology and 11 had intermediate or high grade lymphoma histology. After a median follow-up of 34 months, eight patients are alive, seven without recurrent lymphoma. Five patients had early deaths. The disease-free survival for the entire group is 26% with an overall survival of 29%. There was no difference in survival rate on the basis of disease or histology. Comparing preparative regimens containing TBI to those without there was no difference in survival rate (P = 0.35). Neither age nor sex was a significant determinant of outcome (P = 0.63 and 0.36, respectively). Disease status at the time of transplantation proved to be the important determinant of outcome. Patients transplanted with chemotherapy sensitive disease (n = 9), defined as a partial or complete response to salvage chemotherapy, had a survival rate of 42%, which was significantly better than those who had refractory disease at transplantation (n = 14), who had a survival rate of 21% (P = 0.006). However, this small, but significant fraction of patients with refractory disease was curable. Thus, our data demonstrate that allogeneic bone marrow transplantation is an effective means of treatment for relapsed or aggressive Hodgkin's and non-Hodgkin's lymphoma.

Adolescent↗
PubMed1994

The areas of language: critical analysis.

To determine the degree of linguistic maturity of a child, a series of areas that are usually formally tested in the assessment of language were analyzed. Specifically, an individual test of the assessment of language was applied to a sample of 204 children of Granada (Spain) ranging in age from 2.6 to 6.6 years. This test consists of six areas: comprehension, memory, fluency, vocabulary, knowledge, and judgement and intelligence. A factorial analysis of the data was carried out to check the classification of the above-mentioned areas. It is found that in the three following factors the analyzed variables get saturated: 'learned behaviors', 'behaviors which are being learned' and 'memory'.

Child↗
PubMed1994

Development of a Babesia bovis live attenuated vaccine.

Babesia bovis is the blood parasite causing the highest morbidity and mortality of cattle in Cuba. Thus a control program based on immunization with a vaccine using an attenuated strain of the parasite was developed. For this purpose, a virulent B. bovis strain was isolated and then attenuated by the traditional method in which biological characteristics, proteolytic activity and vector transmissibility were studied. The protection conferred by the vaccine was measured by vaccinating cattle which then was challenged with a heterologous strain. In order to assess postvaccination accident risks, 2603 cattle were vaccinated and those showing clinical signs of babesiosis were treated. A study of cost-benefit was performed in a herd where frequent outbreaks of babesiosis occurred; prevalence and clinical case incidence in vaccinated and nonvaccinated animals were determined. Vaccinated animals survived to challenge whereas two control animals died. In 2% of the vaccinated animals less than 6 months of age, postvaccination accidents occurred, whereas in older animals this index was higher (p < 0.001). The cost-benefit study showed a rate of approximately $10 pesos (national currency) for each peso invested due to the high mortality caused by the parasite. Until an effective, killed vaccine is available, vaccination with live vaccines is advantageous to prevent bovine babesiosis.

Animals↗
PubMed1994

Intrapleural chemotherapy without pleurodesis for malignant pleural effusions. LCSG Trial 861.

Malignant pleural effusions are a common and significant problem in patients with advanced malignancies. In contrast to traditional sclerosing agents, intrapleural chemotherapy has the potential advantage of treating the underlying malignancy, in addition to treating the effusion. The Lung Cancer Study Group evaluated intrapleural cisplatin and cytarabine in patients with malignant pleural effusions from a variety of solid tumors. Forty-six patients with cytologically proven symptomatic and previously untreated malignant pleural effusions were entered. Cisplatin, as a single dose of 100 mg/m2, plus cytarabine 1,200 mg, were instilled into the pleural space via a chest tube that was then immediately removed. The overall response rate, complete plus partial at 3 weeks, was 49% (18/37 patients). One patient experienced reversible grade 3 renal toxic reactions, four patients had grade 3 hematologic toxic reactions, and five patients had grade 3 cardiopulmonary toxic reactions. Median length of response was 9 months for a complete remission and 5.1 months for a partial remission. Although chemotherapy has the potential advantage of treating the underlying malignancy in addition to controlling the malignant effusion, intracavitary cisplatin and cytarabine therapy as administered in this trial appears inferior to existing sclerosing agents for the control of malignant pleural effusions. Although administration is safe, it cannot be recommended for the standard control of malignant pleural effusions, but it may have a role incorporated into combination modality therapies for diseases such as malignant pleural mesothelioma.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1994

[BCG vs interferon A for prevention of recurrence of superficial bladder cancer. A prospective randomized study].

A total of 78 patients with superficial bladder carcinoma were prospectively randomized to two groups following complete transurethral resection (TUR). Each received 12 intravesical instillations of 10(7) units interferon A or 120 mg BCG Connaught for 1 year starting 6 weeks post-TUR. After a mean observation period of 24 (13-31) months in the BCG and 25 (6-32) months in the IFN group 5/32 (15.6%) recurrences in the BCG versus 21/35 (60%) in the IFN group were observed (P = 0.0003). In the IFN group 18.4% of the patients had dysuria and 2.6% fever; in the BCG group 35% had fever, 60% cystitis, 1 patient granulomatous epididimoorchitis and 1 patient pneumonitis with granulomatous prostatitis. With our instillation regimen interferon A had few side effects but also no prophylactic effect, whereas BCG had tolerable-seldom severe--side effects and was very effective in preventing recurrences. Perhaps IFN should be given earlier after TUR and in a higher dosage.

Administration, Intravesical↗
PubMed1991

Monocyte phagocytic activity in sickle cell disease.

The phagocytic activity of peripheral blood monocytes from sickle cell disease patients and normal controls was studied using a monocyte monolayer assay. Phagocytosis of antibody-coated red cells by monocytes from patients in stable condition and in normal controls did not differ significantly (7.1 +/- 1.5 vs. 5.3 +/- 0.9%). However, monocytes from sickle cell disease patients during vasoocclusive crises demonstrated increased phagocytic activity compared to the normal controls (11.0 +/- 2.7 vs. 5.3 +/- 0.9%, p less than 0.025). Numerous defects in immune response have been described in association with sickle cell disease. However, monocyte phagocytic activity is not deficient and is not a factor in the predisposition to infections.

Adult↗
PubMed1987

Invasion of human embryo by Enterobius vermicularis.

Two Enterobius vermicularis organisms invading a macerated embryo 2 cm in length were found in the tissue from an endometrial curettage performed for missed abortion in a pregnant woman. Ova from the helminths were recovered from the vagina and endometrium of the patient. This most unusual case provides further evidence for the invading capacity of E vermicularis.

Abortion, Missed↗
PubMed1984

Dysgerminoma of the ovary.

Dysgerminomas of the ovary are rare germ cell tumors. They are more common at puberty. Surgery followed by irradiation has resulted in excellent cure rates in early stages of this disease. This paper is a review of six patients with a diagnosis of dysgerminoma who were treated at the Department of Radiation Oncology, University of Louisville. The controversy on the use of irradiation in Stage Ia tumor is discussed in detail. A review of the literature is also done in this paper.

Adolescent↗
PubMed1983

[Psychopathological aspects of children on hemodialysis].

Psychological effects of hemodyalisis in children with chronic renal failure are studied based on the significance of micturition and chronic disease in child's mind. The condition is analyzed in three stages: dietetics, fistula on the beginning of treatment and long-term hemodyalisis.

Body Image↗
PubMed1982

Progressive isolated segmental anhidrosis.

A patient had progressive segmental anhidrosis, which proved after extensive neurologic and autonomic workup to be an isolated abnormality. Intradermal acetylcholine produced localized sweating in areas of thermoregulatory anhidrosis five months after the onset of symptoms but failed to do so at two years. These findings are consistent with a preganglionic sympathetic lesion affecting a functionally defined subset of sympathetic cells and/or fibers. The alteration of the sudomotor response to intradermal acetylcholine during the course of the illness suggests that the diagnostic utility of pharmacologic sweat tests may be time dependent, limited to a relatively early period following onset of anhidrosis.

Acetylcholine↗
PubMed1981

Subclinical neuropathy associated with chronic obstructive pulmonary disease: possible pathophysiologic role of smoking.

Twenty of 23 patients with chronic obstructive pulmonary disease (COPD) showed electrophysiologic evidence of peripheral nerve dysfunction. Abnormalities of sensory nerve conduction were most common, affecting the sural nerve (20 subjects), ulnar nerve (11), radial nerve (eight), and median nerve (seven). Six subjects had impairment of both sensory and motor nerve function, with the common peroneal being the most frequently affected motor nerve. Clinical signs of neuropathy were found in four patients. Cigarette smoking, expressed as pack-years, was correlated significantly with the electrophysiologic abnormalities. These findings indicate that subclinical polyneuropathy commonly occurs in association with COPD and that this COPD-related neuropathy is correlated with cigarette consumption. From these data we suggest that a substance or substances in cigarette smoke, such as nicotine, taken on a long-term basis, may be toxic to peripheral nerves.

Adult↗
PubMed1981

Failure of indomethacin to affect arginine-induced C-peptide and glucagon release in insulin-treated diabetics. Major role of residual B cell function in conditioning the magnitude of the blood glucose rise after intravenous arginine.

Fourteen insulin-treated diabetics were submitted to an arginine infusion test performed with either 11.7 or 5.85 mg kg-1 min-1 arginine monohydrochloride infused during 40 min with or without previous oral administration of a low (75 + 50 mg) or a high (75 mg + 3 mg/kg) dose of indomethacin. Blood glucose, plasma non-esterified fatty acids, insulin, C-peptide and glucagon were determined at regular intervals before, during and after the arginine infusion. These parameters were totally unaffected by the two doses of indomethacin both in the basal state and during the arginine infusions at the two loads tested. Eight subjects had a basal C-peptide level above 0.07 pmol/ml and a mean (+/- SEM) maximal rise of 0.21 +/- 0.04 pmol/ml during the arginine infusion, whereas the remaining six patients had virtually zero values throughout the tests. The arginine-induced plasma glucagon rise was similar for the two rates of arginine infusion; the sum of the increments in plasma glucagon averaged 877 +/- 120 and 647 +/- 92 pg/ml (p greater than 0.1) for the high and low rates of arginine infusion, respectively. The magnitude of the blood glucose rise appeared independent of the amount of arginine infused. Confirming previous reports, we found that the blood glucose rise after arginine was three to four times higher in subjects without C-peptide than in subjects with C-peptide. The mean glucagon response did not differ significantly between subjects with or without C-peptide. Thus, residual B cell function determines the magnitude of the blood glucose rise but not the glucagon response after intravenous arginine.

Adult↗