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Biomedical subjects

E M Meares

Publications and source records attributed to E M Meares.

At least 37 records · Page 2Linked to original sources
PubMed1979

Prostatitis.

Explore the source record for details and available documents.

Animals↗
PubMed1978

Serum antibody titers in treatment with trimethoprim-sulfamethoxazole for chronic prostatitis.

A comparative study of the clinical, bacteriologic, and serum antibody titer response of 22 men who received therapy with trimethoprim-sulfamethoxazole for chronic prostatitis due to various strains of Escherichia coli was done. Of the 7 patients who were cured by therapy on the basis of clinical and bacteriologic data, 6 of 6 patients who had elevated serum antibody titers prior to treatment demonstrated a decrease to normal range of serum titers during follow-up, confirming disappearance of the bacterial antigen. Of the 15 patients who were not cured on the basis of clinical and bacteriologic data, 12 of 12 patients who had elevated serum antibody titers prior to treatment demonstrated no change in serum titers throughout the study, confirming persistence of the bacterial antigen.

Adult↗
PubMed1977

Serum antibody titers in urethritis and chronic bacterial prostatitis.

Serum antibody titers were measured by direct bacterial agglutination technique against various strains of Escherichia coli found in the fecal flora of a control group of men who had no history of genitourinary tract infection, against the strains of E. coli responsible for urethral infection in 7 men with urethritis, and against the strains of E. coli responsible for prostatic infection in 25 men with chronic prostatitis. Low serum titers were found in both the control group (median titer of 1:20) and in the urethritis group (median titer of 1:10). Excluding 3 men who had self-agglutinating strains, 18 of 22 (82 per cent) in the prostatitis group had serum titers of 1:320 or greater (median titer of 1:640). Measurement of serum antibody titers by this technique can be a valuable adjunct to diagnosis in cases of chronic prostatitis due to strains of E. coli.

Antibodies, Bacterial↗
PubMed1976

Rationale of incidental appendectomy.

In an effort to settle the controversy regarding use of incidental appendectomy, we have reviewed the literature regarding the function of the appendix and its role in the development of cancer, incidence of acute appendicitis, pathologic findings in incidentally removed appendices, and morbidity of incidental appendectomy. Considering all parameters we conclude that incidental appendectomy is a service to the patient and should be done except where specifically contraindicated.

Adolescent↗
PubMed1976

Primary carcinoma of fossa navicularis.

A case of primary carcinoma of the fossa navicularis of the male urethra is discussed. The lesion presented as an ulcerative process that circumferentially involved the external urinary meatus in a sixty-three-year-old man. Initially, the lesion was confused with a superficial carcinoma of the penis, since results of urethroscopic examination were normal. Following midshaft penectomy, despite normal gross appearance of the distal urethra, histologic examination indicated poorly differentiated epidermoid carcinoma along the mucosa of the distal urethra up to the line of surgical resection. Subsequent total penectomy showed only a small area of residual tumor at the line of previous resection. Lymphadenectomy was not performed. The patient remains alive without evidence of residual disease five years later.

Carcinoma, Squamous Cell↗
PubMed1975

Long-term therapy of chronic bacterial prostatitis with trimethoprim-sulfamethoxazole.

Trimethoprim (TMP) meets all of the theoretical requirements of diffusion into, and actual concentration in, human prostatic fluid. When TMP is combined with the sulfonamide sulfamethoxazole (SMX), potentiation of antibacterial activity is achieved and the development of resistant bacterial strains is less likely to occur. In our initial use of TMP-SMX in the treatment of 13 men with chronic bacterial prostatitis due to gram-negative organisms, patients were given two tablets of TMP-SMX twice daily for only 14 days. The results were that two patients (15%) were cured, nine patients (70%) were improved (sterile prostatic fluid during therapy) but eventually relapsed, and two patients (15%) were unchanged by therapy. In our present study 19 patients (31.6%) were totally cured and 9 of 23 (39.1%) gram-negative organisms were permanently cleared from prostatic fluid; 8 of the 9 patients (42.1%) were improved but eventually relapsed with the same organism; 5 of the 19 patients (26.3%) were considered unchanged by therapy.

Acinetobacter Infections↗
PubMed1975

External beam radiation therapy of primary carcinoma of the prostate.

During the past 10 years, some 15 publications have appeared in the English literature on the definitive radiotherapy of prostatic cancer. The long-term followup required for rational assessment of the treatment of prostatic cancer is not yet available for most of these studies. However, in the Stanford series, the direct disease-free survival at 5 years for patients with disease localized to the prostate is 70%; at 10 years, 42%. The direct disease-free survival at 5 years for patients with extracapsular extension in 36%, and at 10 years, 29%. Recently, mapping of potential lymph node metastases has been studies by several authors.Early results of extended-field irradiation required for regional treatment are presented.

Adenocarcinoma↗
PubMed1975

Factors that influence surgical wound infections. Role of prophylactic antibiotic therapy.

A comprehensive review of the factors responsible for postoperative wound sepsis is discussed, along with the experimental basis for the use of prophylatic antibiotics and a review of the results of the use of systemic and topical antibiotics on the incidence of surgical wound infections. Based on the data presented, suggestions are made which should minimize the development of postoperative wound infections.

Age Factors↗